Acute histopathological responses of testicular tissues after different fractionated abdominal irradiation in rats

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dc.authoridTürkkan, Görkem/0000-0002-9084-2599;
dc.authorwosidTürkkan, Görkem/E-7048-2017
dc.authorwosidTürkkan, Görkem/AAM-6705-2021
dc.contributor.authorAkdere, Hakan
dc.contributor.authorCaloglu, Vuslat Yurut
dc.contributor.authorTastekin, Ebru
dc.contributor.authorCaloglu, Murat
dc.contributor.authorTurkkan, Gorkem
dc.contributor.authorMericliler, Meric
dc.contributor.authorBurgazli, Kamil Mehmet
dc.date.accessioned2024-06-12T10:58:26Z
dc.date.available2024-06-12T10:58:26Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To compare the effects of different fractionated doses of abdominal radiation therapy on acute histopathological responses of testicular tissues in rats. Methods: Thirty-three 3-week-old Wistar albino rats were randomized into 6 groups: group 1 (n = 5), control; group 2 (n = 4), hypofractionated total abdominal irradiation (TAI) of 6 Gy/1 fraction/day for 2 days; group 3 (n = 6), hypofractionated TAI of 4 Gy/1 fraction/day for 3 days; group 4 (n = 6), hypofractionated TAI of 3 Gy/1 fraction/day for 4 days; group 5 (n = 6), conventionally fractionated TAI of 2 Gy/1 fraction/day for 6 days; group 6 (n = 6), conventionally fractionated TAI of 1.7 Gy/1 fraction/day for 7 days. Mean epithelial length and diameter of seminiferous tubules of testicular tissues were determined after euthanasia. Results: Initially, a highly significant decrease in both the mean tubular diameter and epithelial height of the seminiferous tubules was demonstrated in all irradiated rats compared with the control group. No significant differences regarding both damage parameters were found between different hypofractionated radiation therapies. Both conventional radiation therapies reduced the epithelial height and mean diameter of the seminiferous tubules to a lesser extent when compared with 6 Gy/1 fraction/day hypofractionated therapy. It was further shown that parameter values were comparable between rats that received 3 Gy/day hypofractionated therapy and rats that received either of the two conventional therapies. Furthermore, although 4 Gy/day hypofractionation decreased tubular diameter and epithelial length to a greater degree compared with the conventional therapy of 1.7 Gy/1 fraction/day, no statistically significant difference was found when compared with conventional therapy of 2 Gy/1 fraction/day. Additionally, no statistically significant difference was demonstrated between the two types of conventional radiotherapy application. Conclusion: The present study demonstrated that hypofractionated abdominal irradiation leads to more prominent tissue damage in the testes than conventional irradiation.en_US
dc.identifier.doi10.1080/00325481.2015.993270
dc.identifier.endpage77en_US
dc.identifier.issn0032-5481
dc.identifier.issn1941-9260
dc.identifier.issue1en_US
dc.identifier.pmid25526226en_US
dc.identifier.scopus2-s2.0-84941585244en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1080/00325481.2015.993270
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20072
dc.identifier.volume127en_US
dc.identifier.wosWOS:000353451700012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofPostgraduate Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConventionalen_US
dc.subjectExternal Beam Radiotherapyen_US
dc.subjectHypofractionateden_US
dc.subjectRadiotherapyen_US
dc.subjectTestisen_US
dc.subjectSeminoma Stage-Ien_US
dc.subjectRadiation-Therapyen_US
dc.subjectProstate-Canceren_US
dc.subjectRectal-Canceren_US
dc.subjectRadiotherapyen_US
dc.subjectTestisen_US
dc.subjectDamageen_US
dc.subjectSpermatogenesisen_US
dc.subjectImpacten_US
dc.subjectInjuryen_US
dc.titleAcute histopathological responses of testicular tissues after different fractionated abdominal irradiation in ratsen_US
dc.typeArticleen_US

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