Think Twice before Interpreting the Skin Prick Test as Age, Body Mass Index, and Atopy Affect Reaction Time and Size

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dc.authoridBeken, Burcin/0000-0001-7677-7690
dc.authoridCelik, Velat/0000-0002-8893-9420
dc.authorwosidBeken, Burcin/GPK-8389-2022
dc.authorwosidYazicioglu, Mehtap/AAB-9587-2022
dc.authorwosidCelik, Velat/IUN-0044-2023
dc.contributor.authorBeken, Burcin
dc.contributor.authorCelik, Velat
dc.contributor.authorGokmirza Ozdemir, Pinar
dc.contributor.authorYazicioglu, Mehtap
dc.date.accessioned2024-06-12T10:51:17Z
dc.date.available2024-06-12T10:51:17Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: The skin prick test (SPT) is a reliable method to confirm sensitization in IgE-mediated allergic diseases; however, it has been reported to be affected by several personal and environmental factors. Our objective was to determine the factors affecting the skin reactivity to histamine and allergens and investigate whether it differs according to age in terms of reading time. Methods: A total of 500 patients, aged 4 months-18 years, were enrolled in the study. Wheal and flare reaction sizes were documented as the mean of the longest and the midpoint perpendicular diameter in the 5th, 10th, 15th, and 20th min. Skin reactivity was compared between children >24 and <= 24 months of age. Results: We found larger histamine and allergen wheal sizes in children >24 months than the ones <= 24 months of age (p < 0.001 and p = 0.007, respectively). The duration of maximum histamine reactivity was 15 min for children >24 months whereas 10 min for children <= 24 months of age. The number of children losing their histamine reactivity after 15 and 20 min was significantly higher in the smaller age-group. Multiple regression analysis revealed a larger histamine reactivity in children >24 months of age, having obesity, and having allergen sensitization (p = 0.002, p = 0.003, and p = 0.018, respectively). Conclusion: It seems more accurate to evaluate SPT after 10 min in children <= 24 months of age. Cutoff values and ideal measurement time according to individual factors such as age, body mass index, or atopy are needed. (c) 2021 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000515414
dc.identifier.endpage843en_US
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.issue9en_US
dc.identifier.pmid33946081en_US
dc.identifier.scopus2-s2.0-85105917929en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage835en_US
dc.identifier.urihttps://doi.org/10.1159/000515414
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18291
dc.identifier.volume182en_US
dc.identifier.wosWOS:000647822400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofInternational Archives Of Allergy And Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergy Diagnosisen_US
dc.subjectHistamineen_US
dc.subjectIgeen_US
dc.subjectInfantsen_US
dc.subjectSkin Prick Testen_US
dc.subjectAllergensen_US
dc.titleThink Twice before Interpreting the Skin Prick Test as Age, Body Mass Index, and Atopy Affect Reaction Time and Sizeen_US
dc.typeArticleen_US

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