Melatonin Improves Left Ventricular Mitochondrial Dynamics in Rats

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dc.authoridUZUN, Metehan/0000-0003-1406-5473
dc.authoridDoganlar, Zeynep Banu/0000-0002-1365-9897
dc.authoridDEMİR, Ufuk/0000-0002-0020-1633
dc.authoridEroğlu, Hüseyin Avni/0000-0002-1040-3255
dc.authoridOztopuz, Rahime Ozlem/0000-0002-1373-6311
dc.authorwosidUZUN, Metehan/JWR-0343-2024
dc.authorwosidDoganlar, Zeynep Banu/B-4845-2008
dc.authorwosidDEMİR, Ufuk/GLV-2038-2022
dc.authorwosidEroğlu, Hüseyin Avni/ABF-4291-2021
dc.authorwosidOztopuz, Rahime Ozlem/AFK-7508-2022
dc.contributor.authorUzun, Metehan
dc.contributor.authorOztopuz, Ozlem
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorDoganlar, Oguzhan
dc.contributor.authorDoganlar, Zeynep Banu
dc.contributor.authorOvali, Mehmet Akif
dc.contributor.authorDemir, Ufuk
dc.date.accessioned2024-06-12T11:07:23Z
dc.date.available2024-06-12T11:07:23Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThere is increasing awareness that efficient and regular mitochondrial dynamics improvement cardiac function and affects the quality of life. Melatonin is a main pineal gland hormones and ameliorates mitochondrial dynamics in many cardiac disorders. For that purpose, we administrated melatonin to healthy rats all day long in order to investigate change in left ventricle mitochondrial dynamics both in the end of the nighttime and daytime. Twenty male Wistar rats (3-4 months age) were randomly assigned into Control (C; n = 10) and Melatonin groups (MEL; 10 mg/kg melatonin added drinking water, n = 10). On the 5th day of the study, 5 rats from the groups were randomly selected and euthanized at 08:00 AM and the remaining 5 rats were euthanized at 20:00 PM from each groups and samples of left ventricle (LV) tissue were harvested. Quantitative real-time PCR and western blot analysis demonstrated that melatonin acts preventive role on mitochondrial fusion and mitophagy through the DRP1/FIS1 and BNIP3/NIX axis, respectively. Additionally, melatonin administration significantly reduced P21 activation, induced cell cycle arrest, P27, finally regulated caspase-depended mitochondrial apoptosis signals in a time dependent manner. Our results suggest that melatonin may emerge as a therapeutic candidate to protect the bioenergetic dynamics of mitochondria in hearth.en_US
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects [TSA-2018-1346]en_US
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University Scientific Research Projects with project number TSA-2018-1346.en_US
dc.identifier.doi10.3103/S0095452722020116
dc.identifier.endpage195en_US
dc.identifier.issn0095-4527
dc.identifier.issn1934-9440
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85128482542en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://doi.org/10.3103/S0095452722020116
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22012
dc.identifier.volume56en_US
dc.identifier.wosWOS:000784966300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofCytology And Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKeywordsen_US
dc.subjectMelatoninen_US
dc.subjectHearten_US
dc.subjectApoptosisen_US
dc.subjectMitochondrial Dynamicsen_US
dc.subjectMitophagyen_US
dc.subjectCell-Deathen_US
dc.subjectMitophagyen_US
dc.subjectFissionen_US
dc.subjectApoptosisen_US
dc.subjectFusionen_US
dc.subjectBnip3en_US
dc.subjectHearten_US
dc.subjectNixen_US
dc.subjectMechanismsen_US
dc.subjectMorphologyen_US
dc.titleMelatonin Improves Left Ventricular Mitochondrial Dynamics in Ratsen_US
dc.typeArticleen_US

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