Sequential pulmonary effects of radiotherapy detected by functional and radiological end points in women with breast cancer

Basit Öğe Kaydı
dc.contributor.authorTokatli, F
dc.contributor.authorKaya, M
dc.contributor.authorKocak, Z
dc.contributor.authorTure, M
dc.contributor.authorMert, S
dc.contributor.authorUnlu, E
dc.contributor.authorAlkaya, F
dc.date.accessioned2024-06-12T10:55:11Z
dc.date.available2024-06-12T10:55:11Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAims: To determine the pulmonary effects of locoregional irradiation on clinical and sub-clinical radiographic and functional end points in women with breast cancer, and whether the course of these end points is affected by laterality. Materials and methods: Twenty patients (10 irradiated on the left side and 10 irradiated on the right side) were prospectively evaluated for changes in pulmonary function tests, Tc-99m DTPA (diethylenetriamine pentaacetic acid) lung clearance scintigraphy and high-resolution computed tomography (HRCT) at 6, 16 and 52 weeks after radiotherapy. Tc-99m DTPA clearance, expressed as the biological half-time, T (1/2), was computed from the time-activity curves for 10 min for each lung. The irradiated lung volume was calculated for each patient. Results: The mean irradiated lung volume was 6.4% +/- 2 (range 3-11 %) for the entire population. In the whole study population, two (10%) patients, who were irradiated on the left side, had mild symptomatic radiation pneumonitis in the follow-up period. There was a statistically significant gradual reduction in all pulmonary function test values during the follow-up period. For patients irradiated on the left side, Tc-99m DTPA clearance T-1/2 values were statistically significantly decreased during the follow-up period (P = 0.03), but the decrease was not statistically significant for patients irradiated on the right side (P = 0.62). Tc-99m DTPA clearance T-1/2 values were statistically significantly decreased in the irradiated lung compared with the opposite lung, and no improvement was seen at week 52 after radiotherapy. The number of patients with changes on HRCT scans increased after radiotherapy, reaching a maximum at 16 weeks, when 80% of patients had changes. There was subsequent partial recovery 52 weeks after radiotherapy. Conclusion: Locoregional irradiation for breast cancer may cause sub-clinical irreversible impairment of radiological and functional pulmonary parameters. The increase in clearance rate of Tc-99m DTPA may be more prominent for patients with left-sided breast cancer. Tokatli, F. et al. (2005). (C) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.clon.2004.07.012
dc.identifier.endpage46en_US
dc.identifier.issn0936-6555
dc.identifier.issn1433-2981
dc.identifier.issue1en_US
dc.identifier.pmid15714928en_US
dc.identifier.scopus2-s2.0-11844260796en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1016/j.clon.2004.07.012
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19329
dc.identifier.volume17en_US
dc.identifier.wosWOS:000226435100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Londonen_US
dc.relation.ispartofClinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectComputed Tomographyen_US
dc.subjectPulmonary Function Testsen_US
dc.subjectRadiation-Induced Pulmonary Injuryen_US
dc.subjectTc-99m DTPA Lung Clearance Scintigraphyen_US
dc.subjectResolution Computed-Tomographyen_US
dc.subjectIrradiated Lung-Volumeen_US
dc.subjectRadiation Pneumonitisen_US
dc.subjectInjuryen_US
dc.subjectTherapyen_US
dc.subjectComplicationsen_US
dc.subjectPermeabilityen_US
dc.subjectChemotherapyen_US
dc.subjectPredictorsen_US
dc.subjectSurgeryen_US
dc.titleSequential pulmonary effects of radiotherapy detected by functional and radiological end points in women with breast canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu