Third trimester maternal plasma total fibronectin levels in pregnancy-induced hypertension: Results of a tertiary center

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dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorAydin, T
dc.contributor.authorVarol, FG
dc.contributor.authorSayin, NC
dc.date.accessioned2024-06-12T11:01:57Z
dc.date.available2024-06-12T11:01:57Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate maternal plasma total fibronectin values in pregnancy-associated hypertension in women in the third trimester of pregnancy. A total of 125 pregnant women at the 24th week of gestation participated in this study. Nonpregnant normotensive women were included as control group (n = 30). Plasma samples for fibronectin were obtained at the 24th, 28th, and 32nd weeks of gestation from all pregnant patients. From this cohort, 10 patients met the criteria for the diagnosis of gestational hypertension and 15 women met the stringent requirements of preeclampsia, whereas 100 patients were normotensive later in gestation. Plasma total fibronectin levels were determined by radial immunodiffusion technique. Data were analyzed using the SPSS program. The mean plasma fibronectin levels of the pregnant women in whom gestational hypertension and preeclampsia developed were significantly higher at the 24th, 28th, and 32nd weeks in comparison to normotensive pregnant women (p < 0.001). However, throughout the period from the 24th to 32nd weeks of pregnancy, plasma total fibronectin levels did not exhibit a significant change in normotensive pregnant patients or in patients with preeclampsia and gestational hypertension. There was also no correlation between plasma fibronectin levels and gestational age, mean arterial pressure, birth weight, and 5-minute Apgar scores in all groups (p < 0.05). The elevated maternal plasma fibronectin level over 40 mg/dL is capable of predicting preeclampsia with a sensitivity of 73% and a specificity of 92%. These results suggest that serial plasma fibronectin measurements before 24 weeks' of gestation may be helpful in the early detection of preeclampsia in normotensive gravid women who are destined to become clinically preeclamptic.en_US
dc.identifier.doi10.1177/107602960601200106
dc.identifier.endpage39en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue1en_US
dc.identifier.pmid16444432en_US
dc.identifier.scopus2-s2.0-32344435666en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1177/107602960601200106
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21088
dc.identifier.volume12en_US
dc.identifier.wosWOS:000235089800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical And Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFibronectinen_US
dc.subjectPreeclampsiaen_US
dc.subjectGestationai Hypertensionen_US
dc.subjectTurkish Populationen_US
dc.subjectCellular Fibronectinen_US
dc.subjectEndothelial Involvementen_US
dc.subjectPredictive Valueen_US
dc.subjectPreeclampsiaen_US
dc.subjectMarkersen_US
dc.subjectDisordersen_US
dc.subjectAdhesionen_US
dc.subjectDamageen_US
dc.subjectWomenen_US
dc.titleThird trimester maternal plasma total fibronectin levels in pregnancy-induced hypertension: Results of a tertiary centeren_US
dc.typeArticleen_US

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