Trace Elements in a Rat Model of Cadmium Toxicity: the Effects of Taurine, Melatonin and N-Acetylcysteine

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dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorCakina, Suat
dc.contributor.authorSipahi, Tammam
dc.contributor.authorKaymak, Kadir
dc.contributor.authorSener, Seralp
dc.date.accessioned2024-06-12T11:16:32Z
dc.date.available2024-06-12T11:16:32Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: This study was undertaken to investigate copper, zinc, iron, and selenium in a rat model of cadmium toxicity and effects of antioxidant substances such as taurine, melatonin and N-acetylcysteine. Materials and Methods: Ninety male Sprague Dawley rats were divided into nine groups. Group 1 received tap water comprising the controls; the remaining eight groups received 200 mu g/ml cadmium chloride (CdCl2) for three months. Group 2 had CdCl2. Groups 3, 4, and 5 were administered taurine, melatonin and N-acetylcystein for three months together with CdCl2. Groups 6, 7, 8, and 9 had CdCl2 for three months and then only water as the second control or antioxidants for seven days. Cadmium, copper, zinc, iron, and selenium levels of heart and brain were measured by atomic absorption spectrophotometer. Results: Cadmium accumulated in significant amounts in brain and heart tissues when compared with controls. CdCl2 levels in Group 1 and Group 2 were 2.56+/-0.77 and 27.2+/-5.82 in the heart, 46.16+/-14.81 and 300.34+/-58.19 in the brain, respectively (p<0.001). We found that melatonin was more effective in brain tissue (p<0.05) whereas N-acetylcysteine was more effective in heart tissue (p<0.001) against cadmium accumulation. Conclusion: We suggest that taurine, melatonin and N-acetylcysteine have some protective effects in brain and heart tissues against cadmium accumulation. Furthermore, trace element levels were restorated in different degrees after taurine, melatonin and N-acetylcysteine administration.en_US
dc.identifier.endpage27en_US
dc.identifier.issn1301-3149
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-77950469657en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24358
dc.identifier.volume27en_US
dc.identifier.wosWOS:000277173500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrace Elementsen_US
dc.subjectCadmiumen_US
dc.subjectTaurinen_US
dc.subjectMelatoninen_US
dc.subjectN-Acetylcysteinen_US
dc.subjectRaten_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectInduced Hepatotoxicityen_US
dc.subjectTissuesen_US
dc.subjectMetalsen_US
dc.subjectLiveren_US
dc.subjectZincen_US
dc.titleTrace Elements in a Rat Model of Cadmium Toxicity: the Effects of Taurine, Melatonin and N-Acetylcysteineen_US
dc.typeArticleen_US

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