Soluble endothelial protein C receptor level in obesity

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dc.authoridTaşkıran, Bengür/0000-0003-4842-450X
dc.authorwosidTaşkıran, Bengür/AAA-3574-2020
dc.contributor.authorTaskiran, Bengur
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorDemir, Ahmet Muzaffer
dc.contributor.authorOkman, Tulay Kilic
dc.date.accessioned2024-06-12T11:00:28Z
dc.date.available2024-06-12T11:00:28Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and aims: Obesity is a common disorder and is a known risk factor for vascular thrombotic events. The protein C anticoagulant system serves many anti-inflammatory functions. The soluble form of endothelial protein C (sEPCR) circulating in plasma precludes protein C activation and inhibits the anticoagulant activity of activated protein C. The aim of the study is to determine high sensitive C-reactive protein (CRP) and soluble EPCR levels among obese women. Methods: Seventy five postmenopausal women were enrolled in to one of two groups according to body mass index (BMI), 45 obese (BMI >= 30 kg/m(2)) and 30 non-obese (BMI<30 kg/m(2)). Plasma levels of soluble EPCR and hsCRP were determined by ELISA. Results: HsCRP was significantly higher in the obese subjects compared to their non-obese counterparts (0.90 +/- 1.25 mg/l vs 0.46 +/- 0.45 mg/l, p=0.006). Soluble EPCR levels did not differ between the obese and non-obese groups (p=0.494). HsCRP was positively correlated with BMI and waist circumference (r=0.341, p=0.004; r=0.348, p=0.04, respectively). Soluble EPCR showed no significant correlation with these measures. Conclusions: We also detected a wide range of interindividual variability in sEPCR level (40.77-892.82 ng/ml for non obese, 6.09-1339.25 ng/ml for obese). Although the obese had higher sEPCR, the difference was not statistically significant. A well-established inflammatory marker, hsCRP was significantly higher in the obese. There was no relation between hsCRP and sEPCR. Consequently we suggest that sEPCR does not contribute to the inflammation and increased propensity for coagulation in the postmenopausal stage. Obesity and Metabolism 2009; 5: 134-138.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Funden_US
dc.description.sponsorshipThe study was granted by Trakya University Scientific Research Projects Fund.en_US
dc.identifier.endpage138en_US
dc.identifier.issn1825-3865
dc.identifier.issn1826-7572
dc.identifier.issue3-4en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20852
dc.identifier.volume5en_US
dc.identifier.wosWOS:000272267900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofObesity And Metabolism-Milanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEPCRen_US
dc.subjectObesityen_US
dc.subjectProtein Cen_US
dc.subjectThrombosisen_US
dc.subjectSystemic-Lupus-Erythematosusen_US
dc.subjectCoronary-Heart-Diseaseen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectPlasma-Levelsen_US
dc.subjectInflammationen_US
dc.subjectRisken_US
dc.subjectThrombomodulinen_US
dc.subjectCoagulationen_US
dc.subjectExpressionen_US
dc.subjectMortalityen_US
dc.titleSoluble endothelial protein C receptor level in obesityen_US
dc.typeArticleen_US

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