Relationships existing between the serum cytokine levels and bone mineral density in women in the premenopausal period affected by Graves' disease with subclinical hyperthyroidism

Basit Öğe Kaydı
dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorUgur-Altun, B
dc.contributor.authorAltun, A
dc.contributor.authorArikan, E
dc.contributor.authorGuldiken, S
dc.contributor.authorTugrul, A
dc.date.accessioned2024-06-12T11:03:35Z
dc.date.available2024-06-12T11:03:35Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe examined the relationships existing between serum cytokine levels and bone mineral density (BMD) in women of premenopausal age affected by Graves' disease with subclinical hyperthyroidism. The study population consisted of 21 women with untreated hyperthyroid Graves' disease (group H) (age, 36 +/- 2 years), eight women with untreated subclinical hyperthyroid status (group SH) (age, 33 +/- 5 years) and 10 healthy women (group N) (age, 35 +/- 3 years). The following measurements were made in all patients: free T-4 (fT(4)), free T-3 (fT(3)), thyroid stimulating hormone (TSH), TSH receptor antibody (TRab), anti-thyroid peroxidase antibody (anti-TPO), anti-thyroglobulin antibody (anti-Tg), interleukin-2 receptor (IL-2r), interleukin-4 (IL-4), interleukin-8 (IL-8) and interleukin-13 (IL-13). IL-2r and IL-8 levels significantly increased in group H compared with group SH (p < 0.01 and p = 0.05, respectively) and group N (p < 0.001 and p = 0.02, respectively). IL-4 and IL-13 levels tended to be lower in groups H and SH compared with group N, although this difference did not reach statistical significance. Bone mineral density was significantly reduced in only two areas of the femur in group H compared with group N. There was no difference in BMD between groups SH and N. There was no correlation between thyroid hormones, serum cytokine levels and BMD in either group. In conclusion, these results suggest that there were no relationships existing between the serum level of these cytokines and BMD in women of premenopausal age affected by Graves' disease with subclinical hyperthyroidism.en_US
dc.identifier.doi10.1081/ERC-120026945
dc.identifier.endpage398en_US
dc.identifier.issn0743-5800
dc.identifier.issn1532-4206
dc.identifier.issue4en_US
dc.identifier.pmid14682468en_US
dc.identifier.scopus2-s2.0-0344736885en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://doi.org/10.1081/ERC-120026945
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21708
dc.identifier.volume29en_US
dc.identifier.wosWOS:000187163300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofEndocrine Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperthyroidismen_US
dc.subjectCytokineen_US
dc.subjectOsteoporosisen_US
dc.subjectPremenopausalen_US
dc.subjectAutoimmune Thyroid-Diseaseen_US
dc.subjectPostmenopausal Osteoporosisen_US
dc.subjectHuman Osteoblastsen_US
dc.subjectExpressionen_US
dc.subjectCellsen_US
dc.subjectInterleukin-6en_US
dc.subjectResorptionen_US
dc.subjectReceptoren_US
dc.subjectIl-13en_US
dc.subjectThyrotoxicosisen_US
dc.titleRelationships existing between the serum cytokine levels and bone mineral density in women in the premenopausal period affected by Graves' disease with subclinical hyperthyroidismen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu