Pulmonary microvascular permeability and gas exchange in patients with syndrome X

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authoridSalihoglu, Yavuz Sami/0000-0003-2465-9128
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authorwosidAKTOZ, MERYEM/M-9023-2018
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorDurmus-Altun, G.
dc.contributor.authorVardar, S. A.
dc.contributor.authorSalihoglu, Y. S.
dc.contributor.authorAktoz, M.
dc.contributor.authorDirlik, B.
dc.contributor.authorAltun, A.
dc.date.accessioned2024-06-12T11:16:03Z
dc.date.available2024-06-12T11:16:03Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: This clinical study was planned to assess pulmonary microvascular permeability in patients with Syndrome X (SX) by using a functional imaging tool, technetium-99m-diethyltriaminepentaaceticacid (Tc-99m-DTPA) lung clearance scintigraphy, and the pulmonary functions test, which includes diffusion capacity of the lung for carbon monoxide (DLCO). Methods: The study population consisted of 22 non-smoker subjects divided into two groups. First group comprised 12 patients (4 male, 8 female, mean age: 48 +/- 4 years, range 36 to 65) with SX. Ten healthy subject (4 men, 6 female, mean age: 45 +/- 3 years, range 34 to 58) were served as control group. Volumetric pulmonary functions, including DLCO were also performed before lung scintigraphy. Alveolar epithelial permeability was assessed by measuring the pulmonary clearance of an inhaled Tc-99m-DTPA using a gamma camera. Results: Spirometric data was comparable in both groups. Although volumetric pulmonary measurements were similar, DLCO values of SX patients were lower than those in control (20.9 +/- 1.7 ml/min/mmHg vs. 27.8 +/- 1.3 ml/min/mmHg, p=0.002). The mean clearance rate of Tc-99m-DTPA in control subjects was 106 +/- 6 min, and this value was lower than patients with SX (179 +/- 19 min; p=0.0001). Conclusion: We conclude that lung is a target organ for SX. The pulmonary gas exchange and microvascular permeability, which is measured by 99mTc-DTPA scintigraphy, are restricted without change of volumetric pulmonary functions in patients with SX. Hippokratia 2012; 16 (2): 113-117en_US
dc.identifier.endpage117en_US
dc.identifier.issn1108-4189
dc.identifier.issue2en_US
dc.identifier.pmid23935265en_US
dc.identifier.scopus2-s2.0-84859043668en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24178
dc.identifier.volume16en_US
dc.identifier.wosWOS:000302819600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLithographiaen_US
dc.relation.ispartofHippokratiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTc-99m-DTPAen_US
dc.subjectSyndrome Xen_US
dc.subjectLungen_US
dc.subjectCarbon Monoxide Diffusing Capacityen_US
dc.subjectMicrovascularen_US
dc.subjectLeft-Ventricular Dysfunctionen_US
dc.subjectEpithelial Permeabilityen_US
dc.subjectCoronary-Arteriesen_US
dc.subjectAngina-Pectorisen_US
dc.subjectLungen_US
dc.subjectFlowen_US
dc.subjectInflammationen_US
dc.subjectTc-99m-Dtpaen_US
dc.subjectClearanceen_US
dc.subjectExerciseen_US
dc.titlePulmonary microvascular permeability and gas exchange in patients with syndrome Xen_US
dc.typeArticleen_US

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