Clinical, pathological and endocrinological evaluationof patients with microscopic transsphenoidal pituitarysurgery

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dc.contributor.authorÖzçelik, Serhat
dc.contributor.authorGökkaya, Naile
dc.contributor.authorTiryaki, Mehmet
dc.contributor.authorAydoğmuş, Evren
dc.contributor.authorÇelik, Mehmet
dc.contributor.authorYavuzer, Dilek
dc.contributor.authorAydin, Kadriye
dc.date.accessioned2024-06-12T10:05:37Z
dc.date.available2024-06-12T10:05:37Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Detailed evaluation of patients in preoperative stage is an important factor that reduces morbidity and mortality as well as theoperation itself. In our study, we aimed to examine clinically, pathologically and endocrinologically, the patients who were decided toundergo transsphenoidal surgery, in light of the literature. Materials and Methods: In this retrospective observational study, preoperative and pathological data of consecutive pituitaryadenoma patients who applied to our department from January 2019 to June 2020 and underwent transsphenoidal surgery withmicroscopic methods, were examined. Results: The study included a total of 31 patients. Distribution of patients in relation to pathological diagnoses was as follows:Functional pituitary adenoma (n: 15), non-functional adenoma (n: 11), apoplexy (n: 2), carcinoma metastasis (n: 2) andcraniopharyngioma (n: 1). No statistically significant difference was found between functional and non-functional adenomas, interms of tumor size, cavernous sinus invasion, Ki-67 index and p53 staining pattern (p> 0.05) whereas presence of suprasellarextension and visual field defect were significantly more in non-functional adenomas (p = 0.015, p = 0.045, respectively). Conclusion: Highly invasive character was detected in both functional and non-functional pituitary Ki-67 indexes were low in thestudy population, increased p53 expression was noticeable. We can state that the Ki-67 index may not be directly proportional tothe invasive behavior of the disease.en_US
dc.identifier.doi10.5455/annalsmedres.2020.07.697
dc.identifier.endpage563en_US
dc.identifier.issn2636-7688
dc.identifier.issue3en_US
dc.identifier.startpage558en_US
dc.identifier.trdizinid464073en_US]
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.07.697
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/464073
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13545
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleClinical, pathological and endocrinological evaluationof patients with microscopic transsphenoidal pituitarysurgeryen_US
dc.typeArticleen_US

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