Comparison of Ki-67 proliferative index between eutopic and ectopic endometrium: A case control study

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dc.authoridZergeroğlu, Sema/0000-0003-2348-7379
dc.authoridmoraloglu tekin, ozlem/0000-0001-8167-3837
dc.authoridKahyaoglu, Inci/0000-0002-2283-9128
dc.authorwosidZergeroğlu, Sema/ABI-4890-2020
dc.authorwosidKahyaoglu, Inci/X-1237-2019
dc.contributor.authorKahyaoglu, Inci
dc.contributor.authorKahyaoglu, Serkan
dc.contributor.authorMoraloglu, Ozlem
dc.contributor.authorZergeroglu, Sema
dc.contributor.authorSut, Necdet
dc.contributor.authorBatioglu, Sertac
dc.date.accessioned2024-06-12T11:00:24Z
dc.date.available2024-06-12T11:00:24Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: In this study, the Ki-67 proliferative indices among the stages of the endometriosis were compared to clarify whether the proliferation was increased with increasing disease stage. Materials and Methods: Thirty-eight patients who underwent surgery either by laparotomy or by laparoscopy with the diagnosis of endometriosis and 21 patients, as controls, who underwent hysterectomy with the diagnosis of myoma uteri and without any endometrial pathology at our hospital between 2005 and 2007 were studied. Biopsy specimens of endometriotic foci and endometriomas in study group, and eutopic endometrium of hysterectomy specimens of control group were studied. Results: Fifty-nine patients were divided into Group 1 (21 patients in control), Group 2 (19 patients in stage I and II of endometriosis), and Group 3 (19 patients in stage III and IV). A moderate correlation between the stage of endometriosis and the degree of Ki-67 staining was found. When Ki-67 immunohistochemical staining was considered according to the threshold value for CA-125 (35 U/mL), Ki-67 positivity was increased with the increase in CA-125 value, but this increase was not statistically significant. Conclusion: Endometriosis shows some characteristics of tumors such as high rate of invasion, getting autonomy, and proliferation as the disease progresses with subsequent damage to target organs. When the stage of the disease increases, environment becomes more suitable for increased proliferation and invasion. In this study, the increase in proliferative activity as the severity increases is shown by the increase in Ki-67 index. As more studies are being conducted in this field, pathogenesis will be clarified, which could help in the development of new treatment modalities. Copyright (C) 2012, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.identifier.doi10.1016/j.tjog.2012.07.013
dc.identifier.endpage396en_US
dc.identifier.issn1028-4559
dc.identifier.issue3en_US
dc.identifier.pmid23040923en_US
dc.identifier.scopus2-s2.0-84867142117en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.1016/j.tjog.2012.07.013
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20814
dc.identifier.volume51en_US
dc.identifier.wosWOS:000311007300013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofTaiwanese Journal Of Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriosisen_US
dc.subjectKi-67 Proliferative Indexen_US
dc.subjectCa-125en_US
dc.subjectMonoclonal-Antibody Ki-67en_US
dc.subjectSoft-Tissue Sarcomasen_US
dc.subjectImmunohistochemical Analysisen_US
dc.subjectCell Proliferationen_US
dc.subjectPositive Cellsen_US
dc.subjectIn-Vitroen_US
dc.subjectExpressionen_US
dc.subjectLesionsen_US
dc.subjectReceptoren_US
dc.subjectCycleen_US
dc.titleComparison of Ki-67 proliferative index between eutopic and ectopic endometrium: A case control studyen_US
dc.typeArticleen_US

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