The value of MRI contrast enhancement in biopsy decision of suspicious mammographic microcalcifications: a prospective multicenter study

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dc.authoridAribal, Erkin/0000-0002-5525-8696
dc.authoridKurt, Nazmi/0000-0001-5618-1785
dc.authoridSOYDEMIR, Efe/0000-0001-6428-6843
dc.authoridTUNCBILEK, NERMIN/0000-0002-8734-1849
dc.authoridKalayci, Cem Burak/0000-0001-9452-7505
dc.authorwosidkaya, handan/HKE-5219-2023
dc.authorwosidAribal, Erkin/AFO-5588-2022
dc.authorwosidKurt, Nazmi/JFA-8132-2023
dc.contributor.authorTaskin, Fusun
dc.contributor.authorKalayci, Cem Burak
dc.contributor.authorTuncbilek, Nermin
dc.contributor.authorSoydemir, Efe
dc.contributor.authorKurt, Nazmi
dc.contributor.authorKaya, Handan
dc.contributor.authorAribal, Erkin
dc.date.accessioned2024-06-12T10:55:10Z
dc.date.available2024-06-12T10:55:10Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives To investigate the inclusion of breast MRI in radiological assessment of suspicious, isolated microcalcifications detected with mammography. Methods In this prospective, multicenter study, cases with isolated microcalcifications in screening mammography were examined with dynamic contrast-enhanced MRI (DCE-MRI) before biopsy, and contrast enhancement of the relevant calcification localization was accepted as a positive finding on MRI. Six experienced breast radiologists evaluated the images and performed the biopsies. Imaging findings and histopathological results were recorded. Sensitivity, specificity, NPV, and PPV of breast MRI were calculated and compared with histopathological findings. Results Suspicious microcalcifications, which were detected by screening mammograms of 444 women, were evaluated. Of these, 276 (62.2%) were diagnosed as benign and 168 (37.8%) as malignant. Contrast enhancement was present in microcalcification localization in 325 (73.2%) of the cases. DCE-MRI was positive in all 102 invasive carcinomas and in 58 (87.9%) of 66 DCIS cases. MRI resulted in false negatives in eight DCIS cases; one was high grade and the other seven were low-to-medium grade. The false-negative rate of DCE-MRI was 4.76%. The sensitivity, specificity, PPV, and NPV for DCE-MRI for mammography-detected suspicious microcalcifications were 95.2%, 40.2%, 49.2%, and 93.3%, respectively. Conclusions In this study, all invasive cancers and all DCIS except eight cases (12.1%) were detected with DCE-MRI. DCE-MRI can be used in the decision-making algorithm to decrease the number of biopsies in mammography-detected suspicious calcifications, with a tradeoff for overlooking a small number of DCIS cases that are of low-to-medium grade.en_US
dc.identifier.doi10.1007/s00330-020-07265-y
dc.identifier.endpage1726en_US
dc.identifier.issn0938-7994
dc.identifier.issn1432-1084
dc.identifier.issue3en_US
dc.identifier.pmid32939619en_US
dc.identifier.scopus2-s2.0-85090939675en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1718en_US
dc.identifier.urihttps://doi.org/10.1007/s00330-020-07265-y
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19323
dc.identifier.volume31en_US
dc.identifier.wosWOS:000570034300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectBreast Carcinoma In Situen_US
dc.subjectMammographyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectCarcinoma In-Situen_US
dc.subjectBreast Mrien_US
dc.subjectScreening Mammographyen_US
dc.subjectLesionsen_US
dc.subjectMetaanalysisen_US
dc.subjectMalignancyen_US
dc.subjectDiagnosisen_US
dc.subjectAccuracyen_US
dc.subjectUtilityen_US
dc.subjectBenignen_US
dc.titleThe value of MRI contrast enhancement in biopsy decision of suspicious mammographic microcalcifications: a prospective multicenter studyen_US
dc.typeArticleen_US

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