Is Flow Cytometry Crossmatch Analysis Using Sera with Different Dilutions Important for Pretransplant Analysis? A Case Report

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dc.contributor.authorSagiroglu, T.
dc.contributor.authorTozkir, H.
dc.contributor.authorKilicarslan-Ayna, T.
dc.contributor.authorYagci, M. A.
dc.contributor.authorSezer, A.
dc.contributor.authorCarin, M.
dc.date.accessioned2024-06-12T11:17:32Z
dc.date.available2024-06-12T11:17:32Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description8th Congress of the Turkish-Transplantation-Centers-Coordination-Association (TTCCA) -- OCT 12-16, 2011 -- Antalya, TURKEYen_US
dc.description.abstractThe most effective form of treatment for chronic renal failure is kidney transplantation from a cadaver or a living donor. For a kidney transplant to be successful, tissue compatibility and a lack of donor-specific anti-human leukocyte antigen (H LA) antibodies in the circulation of the patient are vital, in addition to ABO blood group compatibility. The presence of anti-HLA antibodies. is assayed before transplantation using various methods, but because organ rejections have been observed in previous studies, different techniques are required to detect anti-FILA antibodies. Today, flow cytometry crossmatching is one of the most important and effective techniques in testing for donor-specific anti-HLA antibodies (DSAs). If weakly positive serum is assayed after serial dilution, it can yield high positivity. Herein, we describe the differences between the results for diluted and undiluted weakly positive sera studied using the flow cytometry crossmatch (FCXM) technique. In a recent study, the sera of weakly FCXM-positive patients were diluted 1/50, and the FCXM test was repeated. The use of diluted serum eliminated the effect of the prozone so that the DSAs could be detected.en_US
dc.description.sponsorshipTurkish Transplantat Ctr Coordinat Assoc (TTCCA)en_US
dc.identifier.doi10.1016/j.transproceed.2012.04.019
dc.identifier.endpage1769en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue6en_US
dc.identifier.pmid22841268en_US
dc.identifier.scopus2-s2.0-84864398752en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1767en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2012.04.019
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24750
dc.identifier.volume44en_US
dc.identifier.wosWOS:000307433400083en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlloantibodiesen_US
dc.titleIs Flow Cytometry Crossmatch Analysis Using Sera with Different Dilutions Important for Pretransplant Analysis? A Case Reporten_US
dc.typeConference Objecten_US

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