DNA methylation of the prestin gene and outer hair cell electromotileresponse of the cochlea in salicylate administration

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dc.contributor.authorBulut, Erdoğan
dc.contributor.authorBudak, Metin
dc.contributor.authorÖztürk, Levent
dc.contributor.authorTürkmen, Mehmet T.
dc.contributor.authorUzun, Cem
dc.contributor.authorSipahi, Tammam
dc.date.accessioned2024-06-12T10:13:41Z
dc.date.available2024-06-12T10:13:41Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: Activity of the prestin gene may have a role in the pathogenesis of salicylate-induced ototoxicity. We investigated DNA methylation for prestin gene exon 1 in salicylate-injected guinea pigs. Materials and methods: Fifteen guinea pigs (30 ears) underwent audiological evaluation including 1000 Hz probe-tone tympanometry and a distortion product otoacoustic emission (DPOAE) test. The animals were randomly divided into three groups. Groups 2 (8 ears) and 3 (14 ears) were injected with intramuscular saline and sodium salicylate (200 mg/kg), respectively twice daily for 2 weeks. Group 1 (8 ears) received no injection. DPOAE measurements were performed at baseline; after 1, 2, 4, and 8 h (acute effect); and after 1 and 2 weeks (chronic effect). After audiological measurements, the animals were sacrificed for DNA isolation. Results: While a significant decrease (P < 0.01) was found for the acute effect in all frequencies in Group 3 according to baseline measurements, there was no difference in terms of chronic effect. DNA methylation increased during the acute phase of salicylate administration, whereas it returned to initial levels during the chronic phase. Conclusion: Salicylate-induced changes in DPOAE responses may be related to prestin-gene methylation. These results may have important implications for salicylate ototoxicity.en_US
dc.identifier.endpage1633en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.startpage1626en_US
dc.identifier.trdizinid254641en_US]
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/254641
dc.identifier.urihttps://hdl.handle.net/20.500.14551/14166
dc.identifier.volume47en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDNA methylation of the prestin gene and outer hair cell electromotileresponse of the cochlea in salicylate administrationen_US
dc.typeArticleen_US

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