The Effects of Apelin on Mesenteric Ischemia and Reperfusion Damage in an Experimental Rat Model

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dc.authoridsagiroglu, gonul/0000-0002-1189-4973
dc.authorwosidSagiroglu, Gonul/ABH-1345-2021
dc.authorwosidsagiroglu, gönül/AAB-4472-2021
dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.contributor.authorSagiroglu, Tamer
dc.contributor.authorOguz, Serhat
dc.contributor.authorSagiroglu, Gonul
dc.contributor.authorCopuroglu, Elif
dc.contributor.authorYalta, Tulin
dc.contributor.authorSayhan, Mustafa Burak
dc.contributor.authorYagci, Mehmet Ali
dc.date.accessioned2024-06-12T10:52:15Z
dc.date.available2024-06-12T10:52:15Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Intestinal ischemia-reperfusion (I/R) injury is associated with high morbidity and mortality rates. There is ongoing research to find an effective preventive or treatment agent. We aimed to evaluate the effects of apelin 13 (AP) on intestinal I/R injury in a rat model. Material and Methods: Twenty-four male Sprague-Dawley rats aged 6-8 weeks and weighing 280 +/- 20 g were equally divided into three groups (control, I/R and I/R+AP). The control group underwent superior mesenteric artery (SMA) mobilization alone without any clamping. In the I/R and I/R+AP groups, an atraumatic microvascular bulldog clamp was placed across the SMA at its point of origin from the aorta. In the I/R+AP group, 2 mu g/kg/d apelin was administered intraperitoneally. After 60 minutes of ischemia, relaparotomy was performed to remove the microvascular clamp on the SMA for 3 hours of reperfusion. After 3 hours, tissue samples were obtained for biochemical [malondialdehyde (MDA) and glutathione (GSH) levels] and histopathological analyses. Results: MDA levels were significantly higher in the I/R group compared to the control group. Although MDA levels were lower in the I/R+AP group compared to the I/R group, the difference was not statistically significant. There was also no significant difference between the I/R+AP and I/R groups regarding GSH levels. The median histopathological grade was significantly lower in the I/R+AP group compared to the I/R group (p=0.001). Conclusion: Apelin appeared to have a positive effect on oxidative injury; this did not reach statistical significance. Thus, the role of apelin and associated findings in the initial treatment of intestinal ischemia needs further large-scale animal studies before human use.en_US
dc.identifier.doi10.5152/balkanmedj.2011.036
dc.identifier.endpage152en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue2en_US
dc.identifier.pmid25206985en_US
dc.identifier.scopus2-s2.0-84863086601en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2011.036
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18652
dc.identifier.volume29en_US
dc.identifier.wosWOS:000315504700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApelinen_US
dc.subjectMesenteric Ischemiaen_US
dc.subjectReperfusion Injuryen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectProtectsen_US
dc.subjectIntestineen_US
dc.titleThe Effects of Apelin on Mesenteric Ischemia and Reperfusion Damage in an Experimental Rat Modelen_US
dc.typeArticleen_US

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