The Better Performance Status, the Better Outcome: Laryngeal Carcinoma Treated with Definitive Radiotherapy

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dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidIbis, Kamuran/AAD-1939-2019
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorCaloglu, Murat
dc.contributor.authorTuran, Fatma Nesrin
dc.contributor.authorIbis, Kamuran
dc.contributor.authorKaragol, Hakan
dc.contributor.authorKocak, Zafer
dc.contributor.authorUzal, Cem
dc.date.accessioned2024-06-12T10:55:42Z
dc.date.available2024-06-12T10:55:42Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To evaluate the prognostic factors affecting locoregional control (LRC) and overall survival (OS) of patients with laryngeal carcinoma who were not candidates for surgical treatment due to tumour or host factors but were treated with definitive radiotherapy (RT). Patients and Methods: Sixty-three consecutive patients, treated with definitive RT between 1999 and 2005, were retrospectively analyzed. All patients had histologically proven squamous cell carcinomas of the larynx. The median age was 62 years (range 43-83 years). Follow-up ranged from 22 days to 68 months (median 32 months). Results: The LRC rates at 2 and 5 years were 70% and 48%. The 2- and 5-year OS rates were 65% and 40%. No statistically significant relationship was found between World Health Organization performance status score (WHO PS) and age (p = .21), tumour site (p = .42), overall stage (p = .11), T stage (p = .19), and N stage (p = .69). Multivariate analyses showed that a WHO PS score >= 2 (p < .0001) and RT treatment time >= 50 days (p = .0172) significantly decreased LRC. Moreover, a WHO PS score >= 2 (p < .0001), RT treatment time >= 50 days (p = .0138), and RT dose < 66 Gy (p = .04) were significantly negative prognostic factors on OS. Conclusion: Definitive RT, in patients with early- and more advanced-stage squamous cell carcinoma of the larynx, is an important treatment option. It is clear that patients with good pretreatment PS would get better results from definitive RT.en_US
dc.identifier.doi10.2310/7070.2008.OA0173
dc.identifier.endpage806en_US
dc.identifier.issn1916-0216
dc.identifier.issue6en_US
dc.identifier.pmid19128707en_US
dc.identifier.scopus2-s2.0-64349123678en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage799en_US
dc.identifier.urihttps://doi.org/10.2310/7070.2008.OA0173
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19517
dc.identifier.volume37en_US
dc.identifier.wosWOS:000207463500020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherB C Decker Incen_US
dc.relation.ispartofJournal Of Otolaryngology-Head & Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarcinomaen_US
dc.subjectLarynxen_US
dc.subjectPerformance Statusen_US
dc.subjectPrognostic Factorsen_US
dc.subjectRadiotherapyen_US
dc.titleThe Better Performance Status, the Better Outcome: Laryngeal Carcinoma Treated with Definitive Radiotherapyen_US
dc.typeArticleen_US

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