Protective Effects of Ibuprofen and L-Carnitine Against Whole Body Gamma Irradiation-Induced Duodenal Mucosal Injury

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dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authorwosidUZAL, Mustafa Cem/AAH-2683-2019
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorTuran, Fatma Nesrin
dc.contributor.authorUzal, Mustafa Cem
dc.date.accessioned2024-06-12T11:17:18Z
dc.date.available2024-06-12T11:17:18Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Ibuprofen and L-carnitine have been demonstrated to provide radioprotective activity to the hamster against whole body sublethal irradiation. The purpose of this study is to test those antioxidant drugs, each of which has the capacity of inhibiting mucosal injury, as topical radioprotectants for the intestine. Material and Methods: The male hamsters were divided into the following four groups (n=6): group 1: control group, received saline, 1 ml/100 g by gavage, as placebo. Group 2: irradiated-control group, received whole body irradiation of 8 Gy as a single dose plus physiological saline. The animals in groups 3 and 4 were given a daily dose of 10 mg/kg of ibuprofen and 50 mg/kg of L-carnitine for 15 days respectively, before irradiation with a single dose of 8 Gy. Twenty-four hours after radiation exposure, the hamsters were sacrificed and samples were taken from the duodenum, and the histopatological determinations were carried out. Results: Morphologically, examination of the gamma irradiated duodenum revealed the presence of shortening and thickening of villi and flattening of enterocytes, massive subepithelial lifting. Pretreatment of ibuprofen and L-carnitine with irradiation reduced these histopathological changes. Conclusion: Ibuprofen and L-carnitine administrated by the oral route may be a good radioprotector against small intestinal damage in patients undergoing radiotherapy.en_US
dc.identifier.doi10.5174/tutfd.2009.02685.2
dc.identifier.endpage85en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-79959662198en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.5174/tutfd.2009.02685.2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24658
dc.identifier.volume28en_US
dc.identifier.wosWOS:000293059800016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWhole Body Irradiationen_US
dc.subjectDuodenumen_US
dc.subjectIbuprofenen_US
dc.subjectL-Carnitineen_US
dc.subjectHamsteren_US
dc.subjectSmall-Intestineen_US
dc.subjectRadical Scavengeren_US
dc.subjectRadiation-Damageen_US
dc.subjectRatsen_US
dc.subjectLipoproteinsen_US
dc.subjectCryptsen_US
dc.subjectCellsen_US
dc.subjectIleumen_US
dc.titleProtective Effects of Ibuprofen and L-Carnitine Against Whole Body Gamma Irradiation-Induced Duodenal Mucosal Injuryen_US
dc.typeArticleen_US

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