The effect of hesperetin on ischemia-reperfusion injury in rat ovary

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorGungor, Ayse Nur Cakir
dc.contributor.authorGencer, Meryem
dc.contributor.authorKaraca, Turan
dc.contributor.authorHacivelioglu, Servet
dc.contributor.authorUysal, Ahmet
dc.contributor.authorKorkmaz, Fatma
dc.contributor.authorDemirtas, Selim
dc.date.accessioned2024-06-12T10:52:21Z
dc.date.available2024-06-12T10:52:21Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractHesperidin (HES), a citrus fruit extract, has beneficial effects on various ischemia/reperfusion (I/R) models. We aimed to evaluate the possible positive effects of hesperetin (HPT), an active metabolite of HES, on a rat ovarian I/R model. We divided 24 Wistar Albino rats into four groups. Group I (n = 6) was sham operated, Group II (n = 6) was the I/R group, Group III (n = 6) was the I/R + solvent group and Group IV (n = 6) was the I/R + HPT group. Three hours of ischemia and 3 h of reperfusion were performed on each rat in Groups II, III, and IV. Dimethyl sulfoxide (DMSO) was given intraperitoneally to the rats in the III. Group, and 50 mg/kg of HPT dissolved in DMSO was given intraperitoneally to the rats in the IV. Group 30 min before reperfusion. After 3 h of reperfusion, the ipsilateral ovaries of the rats were examined immunohistochemically to detect apoptosis. Hematoxylin and eosin (H and E) staining demonstrated less edema and hemorrhage in the group where HPT was applied. Caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining showed significantly lower apoptosis in the group where HPT was used when compared to either the I/R or solvent group. To the best of our knowledge, this is the first study that shows the beneficial effects of HPT in an ovarian I/R injury. HPT improved tissue damage and apoptosis caused by I/R injury. To identify the possible positive effects of HPT in ovarian torsion of humans and use in clinical practice, more studies must be performed.en_US
dc.identifier.doi10.1007/s00404-014-3267-8
dc.identifier.endpage769en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue4en_US
dc.identifier.pmid24806622en_US
dc.identifier.scopus2-s2.0-84921959578en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage763en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-014-3267-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18684
dc.identifier.volume290en_US
dc.identifier.wosWOS:000341826700030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Gynecology And Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCaspase 3en_US
dc.subjectFlavononesen_US
dc.subjectHesperidinen_US
dc.subjectTUNELen_US
dc.subjectOvarian Torsionen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectHesperidinen_US
dc.subjectAntioxidanten_US
dc.subjectDamageen_US
dc.subjectProtectsen_US
dc.subjectTorsionen_US
dc.titleThe effect of hesperetin on ischemia-reperfusion injury in rat ovaryen_US
dc.typeArticleen_US

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