The comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin/clavulanate for the treatment of children with acute otitis media

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dc.authorwosidGuzel, Ahmet/AGE-2880-2022
dc.contributor.authorBiner, Betuel
dc.contributor.authorCeltik, Coskun
dc.contributor.authorOner, Naci
dc.contributor.authorKucukugurluoglu, Yasemin
dc.contributor.authorGuzel, Ahmet
dc.contributor.authorYildirim, Cetin
dc.contributor.authorAdali, Mustafa Kemal
dc.date.accessioned2024-06-12T10:50:36Z
dc.date.available2024-06-12T10:50:36Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the study was to evaluate the efficacy of short-course antimicrobial therapies [single intramuscular dose of ceftriaxone (50 mg/kg, not exceeding 1 g), 5 days of azithromycin (10 mg/kg on day 1, then 5 mg/kg daily on days 2-5) and the traditional 10-day course of amoxicillin/clavulanate (90/6.4 mg/kg/day in 2 doses)] in children with acute otitis media (AOM). The study was conducted as a prospective, comparative, open randomized trial between February 2001 and April 2003, and 104 children were enrolled, with a mean age of 3.8 (2.3) years. The clinical and otoscopic assessments of the children were made on days 0, 3, 11 and 30 after admission, and tympanometry was performed on day 30. The patients were diagnosed and followed with a scoring system. Clinical success was achieved in 29/34 patients (85.3%) in the ceftriaxone group, 27/31 patients (87.1%) in the azithromycin group and 34/39 children (87.2%) in the arnoxicillin/clavulanate group. The rate of persistence of middle-ear fluid did not differ between the three groups (p>0.05). During the one-month period, no recurrent case was observed. The most common drug-related adverse effects were associated with the gastrointestinal system. In conclusion, for the treatment of children with AOM, the clinical success of single-dose intramuscular ceftriaxone and of five-day azithromycin treatments was comparable to that of the traditional 10-day therapy with high-dose arnoxicillin/clavulanate.en_US
dc.identifier.endpage396en_US
dc.identifier.issn0041-4301
dc.identifier.issue4en_US
dc.identifier.pmid18246740en_US
dc.identifier.scopus2-s2.0-38349002852en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage390en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18063
dc.identifier.volume49en_US
dc.identifier.wosWOS:000251766900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Otitis Mediaen_US
dc.subjectAzithromycinen_US
dc.subjectCeftriaxoneen_US
dc.subjectAmoxicillin/Clavulanateen_US
dc.subjectResistant Streptococcus-Pneumoniaeen_US
dc.subjectVs. 10 Daysen_US
dc.subjectAmoxicillin-Clavulanateen_US
dc.subjectClinical-Efficacyen_US
dc.subjectDouble-Blinden_US
dc.subjectIntramuscular Ceftriaxoneen_US
dc.subjectTherapyen_US
dc.subjectEradicationen_US
dc.subjectAntibioticsen_US
dc.subjectDiagnosisen_US
dc.titleThe comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin/clavulanate for the treatment of children with acute otitis mediaen_US
dc.typeArticleen_US

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