Protective effect of royal jelly in 2,4,6 trinitrobenzene sulfonic acid-induced colitis in rats

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridUz, Yesim/0000-0002-0381-4590
dc.authoridCan, Guray/0000-0002-6054-9244
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.authorwosidCAN, GÜRAY/AAA-3274-2020
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.contributor.authorKaraca, Turan
dc.contributor.authorUz, Yesim Hulya
dc.contributor.authorDemirtas, Selim
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorCan, Guray
dc.date.accessioned2024-06-12T10:58:05Z
dc.date.available2024-06-12T10:58:05Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective(s): In the present study, we evaluated immunological and immunomodulatory properties of royal jelly (RJ) in 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Materials and Methods: Eighteen adult female Wistar albino rats were divided into three groups of six animals each: a control group that received only saline solution, a TNBS-induced colitis group, and a TNBS-colitis+RJ group that received 250 mg/kg/day of RJ for seven days before the induction of colitis, following by the same treatment for an additional seven days. At the end of the experiment, cardiac blood and colon samples were obtained under deep anaesthesia from the animals in all groups. Serum interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha) and IL-10 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA). Five-micrometrethick sections were stained with haematoxylin-eosin (H&E) for microscopic evaluations. For immunohistochemical evaluations, the paraffin sections were stained with anti-CD3 (cluster of differentiation), anti-CD5, anti-CD8 and anti-CD45. Results: The results showed that the oral RJ treatment inhibited proinflammatory cytokines, IL-1 beta and TNF-alpha secretion, while increasing anti-inflammatory cytokine IL-10 production in the TNBSinduced colitis+RJ group compared with the colitis group not treated with RJ. The colitis was not as severe in the colitis+RJ group, with ulcerative damage, weight loss and inflammatory scores suggesting that impaired CD3-, CD5-, CD8- and CD45-positive T cell immune responses likely mediated the anti-inflammatory effect. Conclusion: The antioxidant and anti-inflammatory properties of RJ protected colon mucosa against TNBS-induced colitis in rats orally treated with RJ.en_US
dc.description.sponsorshipTrakya University Research Fund, Edirne, Turkey [2013/04]en_US
dc.description.sponsorshipThis work was supported by grant no 2013/04 from the Trakya University Research Fund, Edirne, Turkey.en_US
dc.identifier.endpage379en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue4en_US
dc.identifier.pmid26019800en_US
dc.identifier.scopus2-s2.0-84929461405en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage370en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19935
dc.identifier.volume18en_US
dc.identifier.wosWOS:000354996400009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColitisen_US
dc.subjectRatsen_US
dc.subjectRoyal Jellyen_US
dc.subjectTNBSen_US
dc.subjectGamma Agonists Rosiglitazoneen_US
dc.subjectInflammatory-Bowel-Diseaseen_US
dc.subjectTnbs-Induced Colitisen_US
dc.subjectIn-Vitroen_US
dc.subjectNitric-Oxideen_US
dc.subjectT-Cellen_US
dc.subjectTherapyen_US
dc.subjectHoneyen_US
dc.subjectModelen_US
dc.subjectColonen_US
dc.titleProtective effect of royal jelly in 2,4,6 trinitrobenzene sulfonic acid-induced colitis in ratsen_US
dc.typeArticleen_US

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