Effects of methylene blue in acute lung injury induced by blunt chest trauma

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorAyvaz, S.
dc.contributor.authorAksu, B.
dc.contributor.authorKaraca, T.
dc.contributor.authorCemek, M.
dc.contributor.authorTarladacalisir, Y-T
dc.contributor.authorAyaz, A.
dc.contributor.authorMetin, M-S
dc.date.accessioned2024-06-12T10:54:54Z
dc.date.available2024-06-12T10:54:54Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: We studied whether methylene blue (MB) treatment blunts chest trauma-induced lung injury in rats. Material and Methods: Forty male Sprague-Dawley rats, 200-300g, were used. The rats were divided into five groups (n=8): control, early contusion (EC), early contusion + methylene blue (2 mg/kg, EC+MB), late contusion (LC), and late contusion + methylene blue (2 mg/kg, LC+MB). Results: Histopathological analysis showed increased hemorrhage, alveolar wall thickness, edema, and inflammatory cell infiltrates in the EC and LC rats, which decreased upon MB treatment. Immunohistochemical studies revealed that MB reduced activation of inducible nitric oxide synthase (iNOS) and the number of active terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells. A significant increase was observed in the malondialdehyde (MDA) and nitric oxide (NO) levels in the EC group compared to the control group (p<0.05). In addition, a significant decrease was reported in the glutathione (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels (p<0.01), but no significant difference was observed in the catalase (CAT) levels among the groups. The MDA level was significantly higher in the LC group compared to the control group, whereas the GSH level was significantly lower compared to the control group. The NO level in the EC+MB group was significantly lower when compared to the NO level in the EC group (p<0.05). Conclusion: The present study provides evidence that MB might serve as a therapeutic treatment for blunt chest trauma.en_US
dc.identifier.endpage56en_US
dc.identifier.issn1108-4189
dc.identifier.issue1en_US
dc.identifier.pmid25125953en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19207
dc.identifier.volume18en_US
dc.identifier.wosWOS:000335442400011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLithographiaen_US
dc.relation.ispartofHippokratiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlunt Chest Traumaen_US
dc.subjectContusionen_US
dc.subjectMethylene Blueen_US
dc.subjectOxidantsen_US
dc.subjectAntioxidantsen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectNitric-Oxideen_US
dc.subjectContusionen_US
dc.subjectDexamethasoneen_US
dc.subjectModelen_US
dc.subjectRatsen_US
dc.titleEffects of methylene blue in acute lung injury induced by blunt chest traumaen_US
dc.typeArticleen_US

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