Does Oral Monosodium Glutamate Have a Cochleotoxic Effect? An Experimental Study

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dc.authoridErsoy, Onur/0000-0001-9829-7903
dc.authoridUZUN, CEM/0000-0003-3233-7049
dc.authorid, erdogan/0000-0003-2036-6870
dc.authoridGUVEN, SELIS GULSEVEN/0000-0002-7862-0758
dc.authorwosidErsoy, Onur/AAZ-5121-2020
dc.authorwosidBulut, Erdoğan/ABE-7393-2021
dc.authorwosidUZUN, CEM/K-3307-2012
dc.authorwosid, erdogan/C-4135-2015
dc.contributor.authorGuven, Selis Gulseven
dc.contributor.authorErsoy, Onur
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorBulut, Erdogan
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorUzun, Cem
dc.date.accessioned2024-06-12T10:58:02Z
dc.date.available2024-06-12T10:58:02Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: The effect of orally consumed monosodium glutamate (MSG), which is a common additive in the food industry, on the cochlea has not been investigated. The present study aimed to investigate the possible cochleotoxic effects of oral MSG in guinea pigs using electrophysiological, biochemical, and histopathological methods. Methods: Thirty guinea pigs were equally divided into control and intervention groups (MSG 100 mg/kg/day; MSG 300 mg/kg/day). At 1 month, 5 guinea pigs from each group were sacrificed; the rest were observed for another month. Electrophysiological measurements (distortion product otoacoustic emission [DPOAE] and auditory brainstem response [ABR]), glutamate levels in the perilymph and blood samples, and histopathological examinations were evaluated at 1 and 2 months. Results: Change in signal-to-noise ratio at 2 months was significantly different in the MSG 300 group at 0.75 kHz and 2 kHz (p = 0.013 and p = 0.044, respectively). There was no statistically significant difference in ABR wave latencies of the guinea pigs given MSG compared to the control group after 1 and 2 months; an increase was noted in ABR thresholds, although the difference was not statistically significant. In the MSG groups, moderate-to-severe degeneration and cell loss in outer hair cells, support cells, and spiral ganglia, lateral surface junction irregularities, adhesions in stereocilia, and partial loss of outer hair cell stereocilia were noted. Conclusion: MSG, administered in guinea pigs at a commonly utilized quantity and route of administration in humans, may be cochleotoxic.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [119S164]en_US
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, Grant No. 119S164).en_US
dc.identifier.doi10.1159/000518616
dc.identifier.endpage121en_US
dc.identifier.issn1420-3030
dc.identifier.issn1421-9700
dc.identifier.issue2en_US
dc.identifier.pmid34535584en_US
dc.identifier.scopus2-s2.0-85115603940en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.1159/000518616
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19905
dc.identifier.volume27en_US
dc.identifier.wosWOS:000696330400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofAudiology And Neuro-Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCochleotoxicityen_US
dc.subjectApoptosisen_US
dc.subjectBrainstem Auditory Evoked Responsesen_US
dc.subjectMonosodium Glutamateen_US
dc.subjectOtoacoustic Emissionsen_US
dc.subjectGuinea-Pigen_US
dc.subjectHearing-Lossen_US
dc.subjectHuman Organen_US
dc.subjectHair-Cellsen_US
dc.subjectCochleaen_US
dc.subjectEffluxen_US
dc.subjectNeurotoxicityen_US
dc.subjectDegenerationen_US
dc.subjectOtotoxicityen_US
dc.subjectExpressionen_US
dc.titleDoes Oral Monosodium Glutamate Have a Cochleotoxic Effect? An Experimental Studyen_US
dc.typeArticleen_US

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