Tyrosinase Inhibitory Activity of Chemical Constituents of Euphorbia macrostegia

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dc.authoridTopcu, Gulacti/0000-0002-7946-6545
dc.authoridTopcu, Gulacti/0000-0002-7946-6545
dc.authoridChoudhary, M. Iqbal/0000-0001-5356-3585
dc.authorwosidTopcu, Gulacti/AAH-8305-2019
dc.authorwosidTopcu, Gulacti/C-8344-2015
dc.authorwosidChoudhary, M. Iqbal/C-8633-2012
dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorTopcu, Gulacti
dc.contributor.authorAzarpira, Ali
dc.contributor.authorChoudhary, M. Iqbal
dc.date.accessioned2024-06-12T11:01:32Z
dc.date.available2024-06-12T11:01:32Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe chloroform extract of the aerial parts of E. macrostegia has yielded a new compound, 2-(4-hydroxyphenyl)-ethylhentriacontanoate (1), along with hentriacontan-1-ol (2), lupenone (3), cycloart-22-ene-3,25-diol (4), 3,3',4'-tri-O-methylellagic acid (5), cleomiscosin (6), and glucoclioniasterol (stigmast-5-en-3-O-beta-glucopyranoside) (7), and from the ethyl acetate extract of aerial parts of the plant isoquercetin (8), quercetin-3-O-alpha-arabinofuranoside (avicularin) (9), and rutin (10) have been isolated. Compounds 1-10 were tested for their tyrosinase inhibitory activity, and 2 exhibited an IC50 value of 71.4 mu M, almost comparable to standard kojic acid (IC50 58.2 mu M). Compounds 1-4 also showed good activity with IC50 values of 77.2, 78.6, 71.4, and 77.5 mu M, respectively.en_US
dc.description.sponsorshipInternational Center for Chemical and Biological Sciences (Pakistan)en_US
dc.description.sponsorshipOne of the authors (Ozlem Demirkiran) is grateful to the International Center for Chemical and Biological Sciences (Pakistan) for financial support and for providing access to the world class research facilities.en_US
dc.identifier.doi10.1007/s10600-014-1089-3
dc.identifier.endpage813en_US
dc.identifier.issn0009-3130
dc.identifier.issn1573-8388
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84922082758en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage810en_US
dc.identifier.urihttps://doi.org/10.1007/s10600-014-1089-3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20931
dc.identifier.volume50en_US
dc.identifier.wosWOS:000345139600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofChemistry Of Natural Compoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEuphorbia Macrostegia Boiss.en_US
dc.subjectLong Chain Fatty Acidsen_US
dc.subjectFlavonoid Glycosidesen_US
dc.subjectTyrosinase Inhibitory Activityen_US
dc.subject2-(4-Hydroxyphenyl)Ethylhentriacontanoateen_US
dc.titleTyrosinase Inhibitory Activity of Chemical Constituents of Euphorbia macrostegiaen_US
dc.typeArticleen_US

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