Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts

Basit Öğe Kaydı
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridOltulu, Cagatay/0000-0002-6051-3479
dc.authoridHuseyin, Serhat/0000-0003-4118-040X
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.authorwosidOltulu, Cagatay/V-1823-2018
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.contributor.authorAkinci, Melek
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorOltulu, Cagatay
dc.contributor.authorCanbaz, Suat
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorTopuz, Ruhan Deniz
dc.date.accessioned2024-06-12T11:13:53Z
dc.date.available2024-06-12T11:13:53Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: In this study, we aimed to examine the effects of amitriptyline, fluoxetine, tranylcypromine and venlafaxine on saphenous vein grafts in coronary artery bypass graft surgeries. Methods: 59 patients (40 males and 19 females; mean age 65.1 years, distribution: 45-84 years) who had coronary artery bypass graft surgery between February 2014 and May 2016 were included in the study. After the saphenous vein grafts with intact and denuded endothelium were precontracted with 3x10(-6)M phenylephrine, amitriptyline, fluoxetine and tranylcypromine were cumulatively added to isolated organ baths in the range of 10(-11)-3x10(-5)M, while venlafaxine was added in the range of 10(-9)-3x10(-5)M. Then, the antidepressant-induced relaxation responses were recorded isometrically. Results: While the relaxation response of amitriptyline at -6.42 (Log M) was 74.6%, the response at -6.32 (Log M) was 75.5%. While the relaxation response at -6.46 (Log M) of fluoxetine was 68.02%, the response at -6.02 (Log M) was 72.12%. While the relaxation response of tranylcypromine at -7.53 (Log M) was 61.13%, the response at -7.23 (Log M) was 65.53%. While the relaxation response of venlafaxine at -6.21 (Log M) was 29.98%, the response at -5.90 (Log M) was 32.96%. Conclusion: The maximum relaxation at minimum and maximum therapeutic concentrations was obtained with amitriptyline, fluoxetine and tranylcypromine, and the minimum relaxation was obtained with venlafaxine. The relaxation responses were independent of the endothelium.en_US
dc.description.sponsorship[2013/34]en_US
dc.description.sponsorshipResearch Fund of Trakya University x Project Number: 2013/34.en_US
dc.identifier.doi10.21470/1678-9741-2018-0338
dc.identifier.endpage296en_US
dc.identifier.issn0102-7638
dc.identifier.issn1678-9741
dc.identifier.issue3en_US
dc.identifier.pmid31310467en_US
dc.identifier.scopus2-s2.0-85069852426en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage290en_US
dc.identifier.urihttps://doi.org/10.21470/1678-9741-2018-0338
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23709
dc.identifier.volume34en_US
dc.identifier.wosWOS:000476622500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasil Cirurgia Cardiovascen_US
dc.relation.ispartofBrazilian Journal Of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSaphenous Veinen_US
dc.subjectAmitriptylineen_US
dc.subjectFluoxetineen_US
dc.subjectTranylcypromineen_US
dc.subjectVenlafaxineen_US
dc.subjectTricyclic Antidepressantsen_US
dc.subjectRaten_US
dc.subjectNoradrenalineen_US
dc.subjectContractionsen_US
dc.subjectHypotensionen_US
dc.subjectInhibitionen_US
dc.subjectResponsesen_US
dc.titleEffects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Graftsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu