Synthesis and Biological Activity of a New Pt(II) Complex Involving 4-bromo-2,6-bis-hydroxymethyl-phenol and Nicotinamide

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dc.contributor.authorAltun, Ozlen
dc.contributor.authorYoruc, Zeliha
dc.contributor.authorBoz, Mesut
dc.date.accessioned2024-06-12T11:12:28Z
dc.date.available2024-06-12T11:12:28Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the present study, a Pt(II) complex including 4-Bromo-2,6-bis-hydroxymethylphenol (BBHMP) and nicotinamide (NA) was synthesized and structurally analyzed by using spectral and thermal analysis methods. BBHMP and its Pt(II) complex in the presence of BBHMP and NA were investigated for their antimicrobial, cytotoxicity, gene expression, and antioxidant properties. The antimicrobial activity results showed that the platinum complex displayed a significant effect against Staphylococcus aureus and Candida albicans. The cytotoxicity of BBHMP and platinum complex were determined against human prostate adenocarcinoma (DU145) and breast (MCF7) cancer cell lines by applying the MTT assay. Cytotoxicity results suggested that the Pt(II) complex exhibited moderate cytotoxicity against the growth of these cancer cell lines when compared with the reference drug cisplatin is more effective than free BBHMP and NA. Gene expression results proved that the Pt(II) complex is a special bioactive chemical constituent and potential anticancer agent. The results obtained showed that the complex had highly inhibitory effects on gene expression. In addition, Pt(II) complex also displayed effective antioxidant activity.en_US
dc.description.sponsorshipTrakya University [2016/72]en_US
dc.description.sponsorshipThis study was financially supported by Trakya University. Research Fund (TUBAP, project #2016/72) . The antimicrobial, cytotoxicity, and gene expression analysis of the BBHMP and synthesized Pt (II) complex were performed by Trakya University Research Unit (TUTAGEM) .en_US
dc.identifier.endpage3350en_US
dc.identifier.issn1021-9986
dc.identifier.issue10en_US
dc.identifier.startpage3333en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23186
dc.identifier.volume41en_US
dc.identifier.wosWOS:001171135000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJihad Daneshgahien_US
dc.relation.ispartofIranian Journal Of Chemistry & Chemical Engineering-International English Editionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlatinum(II)en_US
dc.subjectBioactive Compoundsen_US
dc.subjectStructural Analysisen_US
dc.subjectBioactivityen_US
dc.subjectIn-Vitro Cytotoxicityen_US
dc.subjectBreast-Cancer Cellsen_US
dc.subjectPlatinum(Ii) Complexesen_US
dc.subjectAntioxidant Activityen_US
dc.subjectCrystal-Structureen_US
dc.subjectThermodynamic Parametersen_US
dc.subjectThermal-Propertiesen_US
dc.subjectMolecular Dockingen_US
dc.subjectMetal-Complexesen_US
dc.subjectDna-Bindingen_US
dc.titleSynthesis and Biological Activity of a New Pt(II) Complex Involving 4-bromo-2,6-bis-hydroxymethyl-phenol and Nicotinamideen_US
dc.typeArticleen_US

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