Urinalysis of individuals with renal hyperfiltration using ATR-FTIR spectroscopy

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dc.authoridSARIGUL, NESLIHAN/0000-0002-5371-7924
dc.authoridKorkmaz, Filiz/0000-0003-3512-3521
dc.authorwosidSARIGUL, NESLIHAN/J-1564-2013
dc.authorwosidKorkmaz, Filiz/GOH-1457-2022
dc.contributor.authorKurultak, Ilhan
dc.contributor.authorSarigul, Neslihan
dc.contributor.authorKodal, Nil Su
dc.contributor.authorKorkmaz, Filiz
dc.date.accessioned2024-06-12T11:20:06Z
dc.date.available2024-06-12T11:20:06Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAbnormal increased glomerular filtration rate (GFR), otherwise known as renal hyperfiltration (RHf), is associated with an increased risk of chronic kidney disease and cardiovascular mortality. Although it is not considered as a disease alone in medicine today, early detection of RHf is essential to reducing risk in a timely manner. However, detecting RHf is a challenge since it does not have a practical biochemical marker that can be followed or quantified. In this study, we tested the ability of ATR-FTIR spectroscopy to distinguish 17 individuals with RHf (hyperfiltraters; RHf (+)), from 20 who have normal GFR (normofiltraters; RHf(-)), using urine samples. Spectra collected from hyperfiltraters were significantly different from the control group at positions 1621, 1390, 1346, 933 and 783/cm. Intensity changes at these positions could be followed directly from the absorbance spectra without the need for pre-processing. They were tentatively attributed to urea, citrate, creatinine, phosphate groups, and uric acid, respectively. Using principal component analysis (PCA), major peaks of the second derivative forms for the classification of two groups were determined. Peaks at 1540, 1492, 1390, 1200, 1000 and 840/cm were significantly different between the two groups. Statistical analysis showed that the spectra of normofiltraters are similar; however, those of hyperfiltraters show diversity at multiple positions that can be observed both from the absorbance spectra and the second derivative profiles. This observation implies that RHf can simultaneously affect the excretion of many substances, and that a spectroscopic analysis of urine can be used as a rapid and non-invasive pre-screening tool.en_US
dc.identifier.doi10.1038/s41598-022-25535-1
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid36463336en_US
dc.identifier.scopus2-s2.0-85143157080en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-022-25535-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25471
dc.identifier.volume12en_US
dc.identifier.wosWOS:000969757300064en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTransform Infrared-Spectroscopyen_US
dc.subjectUric-Acid Excretionen_US
dc.subjectGlomerular Hyperfiltrationen_US
dc.subjectVibrational Spectroscopyen_US
dc.subjectUreaen_US
dc.subjectAssociationen_US
dc.subjectCreatinineen_US
dc.subjectProteinen_US
dc.subjectClassificationen_US
dc.subjectMarkeren_US
dc.titleUrinalysis of individuals with renal hyperfiltration using ATR-FTIR spectroscopyen_US
dc.typeArticleen_US

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