The relationship between mean platelet volume and neutrophil/lymphocyte ratio with inflammation and proteinuria in chronic kidney disease

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dc.authoridBaysal, Mehmet/0000-0001-7681-4623
dc.authoridCoskun Yavuz, Yasemin/0000-0003-1733-9003
dc.authoridHatipoglu, Esra/0000-0001-8361-8866
dc.authoridHatipoglu, Esra/0000-0001-8361-8866
dc.authoridHacıbekiroğlu, Tuba/0000-0003-1814-5972
dc.authoridsevinc, can/0000-0002-4069-9181
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.authorwosidCoskun Yavuz, Yasemin/KGS-7270-2024
dc.authorwosidYilmaz, Gulay/AAP-1142-2020
dc.authorwosidHatipoglu, Esra/ABI-7268-2020
dc.authorwosidHatipoglu, Esra/I-1793-2013
dc.authorwosidHacıbekiroğlu, Tuba/ABH-2380-2020
dc.contributor.authorYilmaz, Gulay
dc.contributor.authorSevinc, Can
dc.contributor.authorUstundag, Sedat
dc.contributor.authorYavuz, Yasemin Coskun
dc.contributor.authorHacibekiroglu, Tuba
dc.contributor.authorHatipoglu, Esra
dc.contributor.authorBaysal, Mehmet
dc.date.accessioned2024-06-12T11:19:28Z
dc.date.available2024-06-12T11:19:28Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAtherosclerosis, which develops as a result of inflammation, is the most important cause of morbidity and mortality in chronic kidney disease (CKD). In this study, we investigated the relationship of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with inflammation and proteinuria in patients with CKD Stage 3-4. Healthy individuals who applied to nephrology clinic for checkup purposes acted as controls. Fifty-three patients and 30 healthy controls were included in the study. Patients with diabetes mellitus, active infection, malignancy, and coronary artery disease were excluded from the study. Biochemistry values and hemograms were recorded for all patients and for control group. NLR was calculated. The relationship between MPV/NLR and protein, fibrinogen, and proteinuria was evaluated. Our study showed a statistically significant difference between CKD group and healthy control (HC) group in uric acid, fibrinogen, C-reactive protein, and NLR values (P < 0.01, P < 0.01, P = 0.01, P < 0.01, respectively). No statistically significant difference was found between CKD and HC groups for MPV (P = 0.307). Correlation analysis revealed a statistically significant relationship between NLR and creatinine (P < 0.00, r = 0.571), uric acid (P < 0.00, r = 0.436), glomerular filtration rate (P < 0.00, r = 0.418), 24 h urine protein (P = 0.004, r = 0.311), and 24 h urine microalbumin (P = 0.001, r = 0.354). A statistically significant relationship was detected between MPV and platelet count (P < 0.001, r = 0.422), age (P = 0.004, r = 0.312), uric acid (P = 0.04, r = 0.226), and fibrinogen (P = 0.023, r = 0.249). Whereas, a statistically significant relationship was detected between NLR and microalbuminuria/proteinuria, there was no statistically significant relationship between MPV and microalbuminuria/proteinuria. Our study showed that the NLR is high in CKD group and is correlated with uric acid and proteinuria, which are known to be associated with atherosclerosis, in patients with CKD. NLR may be a determinant of inflammation and atherosclerosis in patients with CKD.en_US
dc.identifier.endpage94en_US
dc.identifier.issn1319-2442
dc.identifier.issn2320-3838
dc.identifier.issue1en_US
dc.identifier.pmid28098108en_US
dc.identifier.scopus2-s2.0-85040913208en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage90en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25206
dc.identifier.volume28en_US
dc.identifier.wosWOS:000393977100013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofSaudi Journal Of Kidney Diseases And Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeutrophil-Lymphocyte Ratioen_US
dc.subjectProgressionen_US
dc.subjectMortalityen_US
dc.titleThe relationship between mean platelet volume and neutrophil/lymphocyte ratio with inflammation and proteinuria in chronic kidney diseaseen_US
dc.typeArticleen_US

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