Neutrophil to lymphocyte ratio predicts appropriate therapy in idiopathic dilated cardiomyopathy patients with primary prevention implantable cardioverter defibrillator

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dc.authoridACAR, BURAK/0000-0003-3217-5000
dc.authorwosidAcar, Burak/GVT-1660-2022
dc.authorwosidACAR, BURAK/ABD-9011-2021
dc.contributor.authorUcar, Fatih M.
dc.contributor.authorAcar, Burak
dc.date.accessioned2024-06-12T11:18:40Z
dc.date.available2024-06-12T11:18:40Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: To investigate whether an inflammatory marker of neutrophil to lymphocyte ratio (NLR) predicts appropriate implantable cardioverter defibrillator (ICD) therapy (shock or anti tachycardia pacing) in idiopathic dilated cardiomyopathy (IDC) patients. Methods: We retrospectively examined IDC patients (mean age: 58.3 +/- 11.8 years, 81.5% male) with ICD who admitted to outpatient clinic for pacemaker control at 2 tertiary care hospitals in Ankara and Edirne, Turkey from January 2013-2015. All ICDs were implanted for primary prevention. Hematological and biochemical parameters were measured prior procedure. Results: Over a median follow-up period of 43 months (Range 7-125), 68 (33.1%) patients experienced appropriate ICD therapy. The NLR was increased in patients that received appropriate therapy (4.39 +/- 2.94 versus 2.96 +/- 1.97, p<0.001). To identify independent risk factors for appropriate therapy, a multivariate linear regression model was conducted and age (beta=0.163, p=0.013), fasting glucose (beta=0.158, p=0.017), C-reactive protein (CRP) (beta=0.289, p<0.001) and NLR (beta=0.212, p<0.008) were found to be independent risk factors for appropriate ICD therapy. Conclusions: Before ICD implantation by using NLR and CRP, arrhythmic episodes may be predictable and better antiarrhythmic medical therapy optimization may protect these IDC patients from unwanted events.en_US
dc.identifier.doi10.15537/smj.2017.2.15929
dc.identifier.endpage148en_US
dc.identifier.issn0379-5284
dc.identifier.issue2en_US
dc.identifier.pmid28133686en_US
dc.identifier.scopus2-s2.0-85013865061en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.15537/smj.2017.2.15929
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24905
dc.identifier.volume38en_US
dc.identifier.wosWOS:000395637900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectVentricular-Arrhythmiasen_US
dc.subjectNatriuretic Peptideen_US
dc.subjectAtrial-Fibrillationen_US
dc.subjectCollagen Turnoveren_US
dc.subjectSerum Markersen_US
dc.subjectHeart-Failureen_US
dc.subjectAssociationen_US
dc.subjectRecipientsen_US
dc.titleNeutrophil to lymphocyte ratio predicts appropriate therapy in idiopathic dilated cardiomyopathy patients with primary prevention implantable cardioverter defibrillatoren_US
dc.typeArticleen_US

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