An experimental model of aortic surgery and the effect of Iloprost on lung injury

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dc.authoridozdemir, ahmet coskun/0000-0003-4356-0158
dc.authoridHuseyin, Serhat/0000-0003-4118-040X
dc.authoridiscan, sahin/0000-0003-1015-5260
dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.authorwosidÖzdemir, Ahmet Coşkun/AAL-9081-2021
dc.authorwosidÖzdemir, Ahmet Coşkun/ABE-9344-2020
dc.contributor.authorIscan, Sahin
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorOzdemir, A. Coskun
dc.contributor.authorYalta, Tulin
dc.contributor.authorYuksel, Volkan
dc.contributor.authorAksu, Volkan
dc.contributor.authorEge, Turan
dc.date.accessioned2024-06-12T11:03:40Z
dc.date.available2024-06-12T11:03:40Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives. Ischemia/reperfusion (I/R) damage of the lung is a frequently encountered complication following aortic surgery. The aim of the present study is to investigate the histopathological effects of Iloprost on pulmonary damage developed after I/R. Design. Twenty-four Sprague-Dawley rats were randomly divided into 3 groups. In the control group, aortas were not clamped. In the I/R group, aortas were occluded, and after 1 h of ischemia, clamps were removed. After 2 h of reperfusion period, lungs of the rats were extracted. In the I/R + Iloprost group after 1 h of ischemia, Iloprost infusion was initiated, and maintained for the duration of 2 h reperfusion period. For histopathological scoring, density of polymorphonuclear leucocytes, congestion, interstitial edema, and bleeding were semiquantitatively evaluated, and histopathological changes were scored. Results. In the I/R group, multifocal-marked histopathological changes in 5 (62.5%), and multifocal-moderate histopathological changes in 3 (37.5%) rats were detected. In the I/R + Iloprost group, multifocal-moderate histopathological changes in 4 (50%), and multifocal-mild changes in 4 (50%) rats were detected. Conclusions. In the experimental rat model, administration of Iloprost has been shown to have preventive effects for pulmonary damage occurring after I/R generated by infrarenal aortic occlusion.en_US
dc.description.sponsorshipTrakya University Animal Research Committee and Department of Experimental Animal Researchen_US
dc.description.sponsorshipThis study is supported by Trakya University Animal Research Committee and Department of Experimental Animal Research.en_US
dc.identifier.doi10.3109/14017431.2012.761724
dc.identifier.endpage244en_US
dc.identifier.issn1401-7431
dc.identifier.issue4en_US
dc.identifier.pmid23330704en_US
dc.identifier.scopus2-s2.0-84880436684en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://doi.org/10.3109/14017431.2012.761724
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21752
dc.identifier.volume47en_US
dc.identifier.wosWOS:000322607700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofScandinavian Cardiovascular Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIloprosten_US
dc.subjectIschemia/Repolusionen_US
dc.subjectLungen_US
dc.subjectRaten_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectLimb Ischemiaen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectTrialen_US
dc.titleAn experimental model of aortic surgery and the effect of Iloprost on lung injuryen_US
dc.typeArticleen_US

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