Emergence and co-infections of West Nile virus and Toscana virus in Eastern Thrace, Turkey

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dc.authoridOzkul, Aykut/0000-0001-5008-9443
dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.authoridONCUL, Mustafa Oral/0000-0002-1681-1866
dc.authoridGunay, Filiz/0000-0002-2583-6264
dc.authoridULCAY, ASIM/0000-0003-0531-0668
dc.authoridAlten, Bulent/0000-0002-9711-4113
dc.authoridERGUNAY, KORAY/0000-0001-5422-1982
dc.authorwosidInan, Asuman/IXW-7212-2023
dc.authorwosidOzkul, Aykut/A-1973-2016
dc.authorwosidInan, Asuman/D-5679-2014
dc.authorwosidErdem, Hakan/O-2462-2013
dc.authorwosidONCUL, Mustafa Oral/AAE-3429-2020
dc.authorwosidGunay, Filiz/AAC-7874-2020
dc.authorwosidERGUNAY, KORAY/I-8368-2013
dc.contributor.authorErdem, H.
dc.contributor.authorErgunay, K.
dc.contributor.authorYilmaz, A.
dc.contributor.authorNaz, H.
dc.contributor.authorAkata, F.
dc.contributor.authorInan, A. S.
dc.contributor.authorUlcay, A.
dc.date.accessioned2024-06-12T11:16:18Z
dc.date.available2024-06-12T11:16:18Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe objective of this study was to identify the impact of West Nile virus (WNV) and Toscana virus (TOSV) in febrile diseases of unknown aetiology in Eastern Thrace, Turkey; this study was conducted during August-October 2012, and included 18 clinical cases and 296 blood donors for local serosurveillance. Antibodies were determined via commercial assays and further tested for specificity via neutralization assays (NA). Viral RNAs were sought via specific and/or generic primers. WNV infections were diagnosed in seven patients (38.8%), detected via RNA+IgM in four, RNA in one and IgM and low avidity IgG in two cases. The most common symptom was fever (>38 degrees C), followed by headache, malaise/fatigue, myalgia/arthralgia, muscle stiffness/lower back pain, anorexia, nausea/vomiting, diarrhoea, supraorbital/retrobulbar pain and abdominal pain. Neurological symptoms were noted in one individual. WNV strains in RNA-detectable patients were characterized as lineage 1. TOSV RNA or IgM were identified in two individuals with confirmed WNV infections and in one patient without evidence of WNV exposure. The clinical and laboratory findings in individuals with WNV/TOSV co-infection were comparable to those in WNV-induced disease. The TOSV strain in the patient with detectable viral RNA was characterized as genotype A. In local blood donors, seroreactivity for specific WNV and TOSV immunoglobulins was observed in 1.7% (5/296) and 14.4% (26/180), respectively. These findings indicate the emergence of WNV and TOSV-associated diseases in Eastern Thrace. WNV/TOSV co-infections were documented for the first time.en_US
dc.identifier.doi10.1111/1469-0691.12310
dc.identifier.endpage325en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue4en_US
dc.identifier.pmid23910388en_US
dc.identifier.scopus2-s2.0-84895928438en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage319en_US
dc.identifier.urihttps://doi.org/10.1111/1469-0691.12310
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24274
dc.identifier.volume20en_US
dc.identifier.wosWOS:000332685100017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofClinical Microbiology And Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThraceen_US
dc.subjectToscana Virusen_US
dc.subjectTOSVen_US
dc.subjectTurkeyen_US
dc.subjectWest Nile Virusen_US
dc.subjectWNVen_US
dc.subjectSandfly-Feveren_US
dc.subjectCentral Anatoliaen_US
dc.subjectBlood-Donorsen_US
dc.subjectInfectionsen_US
dc.subjectPhlebovirusesen_US
dc.subjectCirculationen_US
dc.subjectOutbreaken_US
dc.subjectStrainsen_US
dc.subjectEuropeen_US
dc.subjectNorthen_US
dc.titleEmergence and co-infections of West Nile virus and Toscana virus in Eastern Thrace, Turkeyen_US
dc.typeArticleen_US

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