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    The protective effect of amifostine on radiation-induced acute pulmonary toxicity
    (Elsevier Science Inc, 2004) Uzal, C; Durmus-Altun, G; Caloglu, M; Ergülen, A; Altaner, S; Yigitbasi, NO
    Purpose: The purpose of this study was to determine by using Tc-99m-diethylenetriaminepentaacetic acid (DTPA) lung scintigraphy whether amifostine given before irradiation protects alveolocapillary integrity in a rabbit model. Methods and Materials: Twenty white New Zealand rabbits were randomly divided into 4 groups: (1) control (CONT), (2) amifostine alone (AMF), (3) radiation (RAD), and (4) radiation plus amifostine (RAD + AMF). The AMF and RAD + AMF groups received amifostine. The RAD and RAD + AMF groups were irradiated to the right hemithorax with a single dose of 20 Gy using a Co-60 treatment unit. Amifostine (200 mg/kg) was given i.p. 30 min before irradiation. The (99)mTc-DTPA radioaerosol study was performed 14 day after irradiation. Results: The mean clearance rate of Tc-99m-DTPA in control subjects was 140 +/- 21 min. The highest It, value was noted in the RAD group (603 105 min, p = 0.001). There were no significant differences between the Tc-99m-DTPA lung clearance rates of the CONT, RAD + AMF (238 +/- 24 min), and AMF groups (227 +/- 54 min). The mean penetration index values of CONT, RAD, AMF, and RAD + AMF are 63% 1.6%, 63% 2.5%, 60% 2.9%, and 63% 2%, respectively. Conclusions: We concluded that amifostine treatment before the lung irradiation protects the lung alveolocapillary integrity. This study confirms the protective effect of amifostine in an acute phase of radiation lung injury. (C) 2004 Elsevier Inc.
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    Use of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy
    (Japanese Society Nuclear Medicine, 2005) Durmus-Altun, G; Altun, A; Aktas, RG; Salihoglu, YS; Yigitbasi, NO
    The purpose of the study was; (i) to deter-mine whether I-123-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with Tc-99m-DTPA radioacrosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent I-123-MIBG and Tc-99m-DTPA radioaerosol scintigraphy at the end of the treatment period. I-123-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after 'intravenous injection of the radiopharmaccutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of I-123-MIBG were determined. Two days after I-123-MIBG scintigraphy, 99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation. I-123-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 +/- 4.6 vs. 40 +/- 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T-1/(2) values of DTPA clearance were significantly increased in AIPT group according to the control group (55 +/- 7.2 vs. 86.6 +/- 18.5,p = 0.02). I-123-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally, Tc-99m-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost.