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Öğe Asymptomatic, Reddish Papules and Pustules with Hemorrhagic Crust on the Trunk of a Girl: Answer of the Last Issue's Case Question(Ortadogu Ad Pres & Publ Co, 2011) Arican, Ozer; Gursel, Yildiz; Yalcin, Omer[Abstract Not Available]Öğe Bronchiolitis Obliterans Organizing Pneumonia: Three Cases Leading to Respiratory Failure(Bilimsel Tip Publishing House, 2005) Altiay, Gundeniz; Hatipoglu, Osman Nuri; Tabakoglu, Erhan; Yalcin, Omer; Caglar, TuncayBronchiolitis obliterans organizing pneumonia (BOOP) is an entity of unknown etiology characterized histologically by granulation tissue plugs within the lumens of small airways extending into the alveolar ducts and airways. The typical presenting symptoms and signs are dyspnea, cough, fever, weight loss, and a chest radiograph with single or multiple alveolar opacities. Some cases progress rapidly and have a poor prognosis. We followed-up three idiopathic BOOP cases in one month. Pathological diagnosis was based on transbronchial lung biopsy (TBLB) in all of them. The characteristic features of all cases were progressive respiratory failure. We treated them with high dose prednisolone for three days (first day 80 mg q6h, second day 80 mg q8h, third day 80 mg q12h) and continued with 1 mg/kg/d prednisolone. We observed rapid radiological and clinical improvement in all cases. Interestingly, these three patients were admitted to our clinic with progressive respiratory failure in the same one month period.Öğe Cardiac rhabdomyoma in an adult patient presenting with right ventricular outflow tract obstruction(Elsevier Ireland Ltd, 2008) Aktoz, Meryem; Tatli, Ersan; Ege, Turan; Yalcin, Omer; Buyuklu, Mutlu; Aksu, Feza; Gul, CetinWe present a 24 year old woman with cardiac rhabdomyoma. Cardiac rhabdomyoma is the most common benign cardiac tumor in infants, but in adults, cardiac rhabdomyoma is very rare. These tumors are often spontaneously reversible because they are associated to the right or left ventricular outflow tract obstruction, tachyarrhythmias and heart failure where surgery is necessary. (C) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe CD30 positive T-cell lymphoproliferative disorder: A case report(Springer, 2007) Puyan, Fulya Oz; Tekgunduz, Emre; Ilgili, Aysegul; Pamuk, Gulsum; Yalcin, Omer; Dogan, Oner[Abstract Not Available]Öğe Complicated xanthogranulomatous pyelonephritis in a child(Wiley-Blackwell Publishing, Inc, 2010) Ozkayin, Nese; Inan, Mustafa; Aladag, Nukhet; Kaya, Meryem; Iscan, Burcin; Yalcin, Omer[Abstract Not Available]Öğe Congenital Pulmonary Airway Malformation Type 2: A Case Report with Review of the Literature(De Gruyter Open Ltd, 2016) Tastekin, Ebru; Usta, Ufuk; Kaynar, Aysegul; Ozdemir, Cigdem; Yalcin, Omer; Ozyilmaz, Filiz; Kutlu, Ali KemalA congenital pulmonary airway malformation is a rare disorder of the pulmonary airway and a hamartomatous mass of disorganized lung tissues with various degrees of cystic change. A 20-year-old pregnant woman who did not have previous clinical follow-up during her pregnancy visited the gynecology department for her first check on the 19th week of gestation. The sonogram, showed severe hydrops fetalis. Laboratory findings were consistent with non-immune hydrops fetalis. Medical abortion was performed and the fetus was sent to our department for a complete fetal autopsy. Macroscopically, whole parts of the fetus had striking oedema. Massive pleural and peritoneal effusions were seen on dissection. The left lung filled the whole thoracic cavity. The heart was displaced to the right and the right lung was compressed. Microscopically, the left lung mass showed dilated bronchiole-like structures (1-20 mm) that were lined with ciliated columnar cells without any intervening mucinous cells. The subepithelial stroma contained thin, interrupted smooth muscle fibers and elastic connective tissue without cartilage plates. Our case is a very good example of non-immune hydrops fetalis associated with congenital pulmonary airway malformation type 2. Prenatal clinical and ultrasonographic follow-ups during pregnancy are very important for early diagnosis of congenital malformations.Öğe Effect of curcumin on ipsilateral and contralateral testes after unilateral testicular torsion in a rat model(Karger, 2008) Basaran, Umit Nusret; Dokmeci, Dikmen; Yalcin, Omer; Inan, Mustafa; Kanter, Mehmet; Aydogdu, Nurettin; Turan, NesrinObjective: The aim of the study was to determine the protective effect of curcumin on testicular ischemia- reperfusion ( I/ R) injury. Materials and Methods: 32 male rats were divided into four groups ( n = 8): group 1: control; group 2: ischemia; group 3: I/ R, and group 4: I/ R+CUR. Curcumin ( 150 mg/ kg, p. o.) was administered before 30 min of reperfusion in group 4. Malondialdehyde ( MDA) levels, Johnsen's testicular biopsy scores, and mean seminiferous tubule diameter measurements were evaluated in testes. In addition, endothelial nitric oxide synthase ( eNOS) and inducible nitric oxide synthase ( iNOS) expressions were evaluated immunohistochemically. Results: MDA levels in control groups were significantly lower than other groups in ipsilateral and contralateral testes. Johnsen's scores in the control group were significantly higher than in other groups. MDA levels and Johnsen's scores in the I/ R+ CUR group were similar to the ischemia and I/ R groups in ipsilateral and contralateral testes. The immunoreactivity of iNOS and eNOS were increased in I/ R ipsilateral testicular groups. After I/ R, iNOS and eNOS expression increased slightly in contralateral groups. Additionally, the curcumin treatment decreased iNOS and eNOS immunoreactivity in ipsilateral and contralateral testes. Conclusion: The results suggest that curcumin did not protect the unilateral nor contralateral testes. This observation may depend on inhibition of iNOS and eNOS due to inhibition of the antioxidant, anti- inflammatory effects of nitric oxide. Copyright (C) 2008 S. Karger AG, Basel.Öğe Effect of L-carnitine on serum paraoxonase, arylesterase and lactonase activities and oxidative status in experimental colitis(Walter De Gruyter Gmbh, 2013) Ozgun, Eray; Ozgun, Gulben Sayilan; Eskiocak, Sevgi; Yalcin, Omer; Gokmen, Selma SuerAim: Oxidative stress plays an important role in the pathogenesis of inflammatory bowel disease. We investigated antioxidant L-carnitine effect on activities of paraoxonase 1 enzyme which is also synthesized in colon and oxidative status in experimental colitis. Material and Methods: Wistar albino female rats were divided into four groups randomly: control, colitis, pre-treatment and treatment groups. To induce colitis, single dose of 1 mL acetic acid (%4) was given intrarectally to colitis, pre-treatment and treatment groups. Single dose of 500 mg/kg L-carnitine was given intraperitoneally 1 hour before inducing colitis to pre-treatment group and 24 hours after inducing colitis to treatment group. All groups were sacrificied 48 hours after intrarectally administration. Existence of colitis was confirmed by histopathological changes. Paraoxonase, arylesterase and lactonase activities, total oxidant and antioxidant status, malondialdehyde, and total sialic acid were measured in serum. Oxidative stress index was calculated from the formula. Results: While serum malondialdehyde, total sialic acid, total oxidant status and oxidative stress index were significantly elevated, serum paraoxonase, arylesterase and lactonase activities and total antioxidant status were significantly decreased in acetic-acid induced experimental colitis. In acetic-acid induced experimental colitis, L-carnitine caused a significant decrease in serum malondialdehyde, total sialic acid, total oxidant status and oxidative stress index but a significant increase in serum arylesterase and lactonase activities of treatment group only. Conclusion: L-Carnitine has an increasing effect on serum arylesterase and lactonase activities and decreasing effect on oxidative stress in acetic acid-induced experimental colitis. Therefore, L-carnitine may be useful for the treatment of inflammatory bowel disease.Öğe The effects of L-carnitine on acetaminophen induced hepatotoxicity in rats(Walter De Gruyter Gmbh, 2013) Aktas, Ozgur; Eskiocak, Sevgi; Ozgun, Gulben Sayilan; Yalcin, Omer; Sut, NecdetObjective: The aim of this study was to investigate the protective effect of L-carnitine against to liver damage caused by lipid peroxidation and oxidative stress in toxic hepatitis induced by acetaminophen. Materials and Methods: Wister-albino male rats were divided into three groups randomly: control, toxic hepatitis, and L-carnitine groups. To introduce a toxic hepatitis, single dose of acetaminophen (300 mg/kg) dissolved in warm saline was given intraperitoneally to toxic hepatitis and L-carnitine groups. A single dose of L-carnitine (500 mg/kg) was given intraperitoneally to L-carnitine group five minutes after introducing to toxic hepatitits. A single dose of warm saline was given intraperitoneally to control group. Results: In toxic hepatitis group, serum alanine and aspartate aminotransferase and plasma and liver malondialdehyde levels were higher whereas plasma Gc-globulin, whole blood and liver glutathione levels, erythrocyte and liver catalase activities and erythrocyte glutathione peroxidase activity were lower as compared to control group. In L-carnitine group, serum alanine and aspartate aminotransferase and plasma and liver malondialdehyde levels were lower whereas whole blood and liver glutathione levels, erythrocyte and liver catalase activities and erythrocyte glutathione peroxidase activity were higher as compared to toxic hepatitis group. There was no significant change between plasma Gc-Globulin levels of these groups. Histopathological changes in toxic hepatitis group were more prominent than those found in L-carnitine group. Conclusion: L-Carnitine has a protective effect against to liver damage caused by lipid peroxidation and oxidative stress in toxic hepatitis induced by acetaminopfen in rats.Öğe The Effects of Thermal Injury on Immature Rat Ear Cartilage(Lippincott Williams & Wilkins, 2010) Aygit, A. Cemal; Benlier, Erol; Top, Husamettin; Yalcin, Omer; Huseyinova, Gulara; Kanter, Mehmet; Cakir, BeyhanThe purpose of this study was to research regeneration and growing properties of an immature rat ear cartilage and its adjacent tissue after a thermal injury. Fifteen 30-day-old male Sprague-Dawley rats were used. Burn wounds were created by applying a heated plaque. All the rats, based on their tissue sampling day, were placed in two groups for histopathologic evaluation. In group I (n = 5), the burned right auricles were amputated on the first day, and the left auricles were amputated as a control at the same time. In group II (n = 10), the burned right auricles were amputated on the 30th day, and the left auricles were amputated as a control at the same time. Epithelization of skin was completed in period ranging between 12 and 15 days in all burned ears. The skin appendages were few throughout the affected area. Chondroid tissue regenerated from perichondrium and increased capillary vessels were observed. On the first day of the burn injury, electron microscopic findings were karyopyknosis, karyorrhexis, and karyolysis of the nucleus, and there were also signs of necrosis. New chondro-blasts were formed around the collagen fibrils in the scar tissue on the 30th day. CD-31 immunohistochemical staining showed increased capillary vessels in the burned ear. The peripheral nerve fibers decreased and regenerative signs of nerves were shown with the use of S-100 immunohistochemical staining. Differentiation of chondroblasts to chondrocytes occurs in the burned immature ear, and new cartilage tissue regenerates from perichondrium. In addition, regenerative signs of nerves appear. (J Burn Care Res 2010; 31: 803-808)Öğe The effects of vitamin C alone or in combination with L-Carnitine in experimental myoglobinuric acute renal failure (MARF)(Oxford Univ Press, 2006) Ustundag, Sedat; Sen, Saniye; Yalcin, Omer; Cukur, Ziya; Demirkan, Bora[Abstract Not Available]Öğe Evaluation of prefabrication of high-density porous polyethylene implants (HDPPIs) by pathology, microangiography and bone scintigraphy(Soc Nuclear Medicine Inc, 2009) Top, Husamettin; Sarikaya, Ali; Benlier, Erol; Yalcin, Omer; Unal, Yasin; Aygit, Cemal[Abstract Not Available]Öğe Experimental myoglobinuric acute renal failure: The effect of vitamin C(Taylor & Francis Ltd, 2008) Ustundag, Sedat; Yalcin, Omer; Sen, Saniye; Cukur, Ziya; Ciftci, Senturk; Demirkan, BoraDuring times of war and natural disasters, rhabdomyolysis-induced myoglobinuric acute renal failure (ARF) can assume epidemic proportions. Free radicals play an important role in the pathogenesis of myoglobinuric ARF. Vitamin C is a major antioxidant, scavenging free radicals. We have not found any studies on the effect of vitamin C on myoglobinuric ARF. Thus, we aimed to investigate the effects of vitamin C on the myoglobinuric ARF formed by glycerol in rats. Three groups of rats were employed in this study. Group 1 served as control, group 2 was given 50% glycerol (10 mL/kg, i.m.), and group 3 was given glycerol plus vitamin C (20 mg/kg, i.p. for four days). Ninety-six hours after glycerol injections, blood samples and kidney tissues were taken from the anesthetized rats. Urea and creatinine levels in plasma; N-acetyl-beta-D-glucosaminidase activity in urine; malondialdehyde levels, superoxide dismutase and catalase enzyme activity in kidney tissue were determined. Histopathological changes and iron accumulation in the kidney tissue were evaluated. In this study, glycerol administration led to marked renal oxidative stress and severe renal functional and morphological deterioration. The treatment of animals with vitamin C partially corrected the renal dysfunction and morphological impairment. In this respect, vitamin C appears to be a promising candidate for the prevention of rhabdomyolysis-induced ARF. Higher dosages of vitamin C than in 20 mg/kg may be beneficial for better functional and morphological recovery in this model ARF.Öğe Frequency of Epstein-Barr virus and human papilloma virus in patients with nasopharyngeal carcinoma(Springer, 2020) Altekin, Ilhan; Tas, Abdullah; Yalcin, Omer; Guven, Selis Gulseven; Aslan, Zulkar; Adali, Mustafa Kemal; Karasalihoglu, Ahmet RifatPurpose Nasopharyngeal cancer is a type of malignancy originating from the epithelial cells lining the nasopharynx. In genetic and environmental factors, infection with Epstein-Barr virus is one of the particular factors held accountable for the etiopathogenesis. Human papillomavirus has been associated with cervical, anogenital, and oropharyngeal cancers. The aim of the present study is to demonstrate the presence and incidence of Epstein-Barr virus and human papillomavirus in patients with nasopharyngeal cancer. Methods The information collected for these patients included age at the time of biopsy, gender, alcohol consumption and smoking, and histopathological type of nasopharyngeal cancer. Only patients for whom nasopharyngeal biopsy was performed as punch biopsy were included in the study. In situ hybridization was performed with formalin-fixed, paraffin-embedded tissue sections for Human Papillomavirus and Epstein-Barr virus nucleic acids obtained by means of automated Ventana BenchMark Medical system Results Utilizing in situ hybridization with samples obtained from 56 patients diagnosed with nasopharyngeal cancer. Epstein-Barr virus was positive in 41 out of the 56 (73.2%) patients, while human papillomavirus was positive in 3 (5.4%), and 1 patient (1.8%) had co-infection. Thirty seven (90.2%) of the 41 patients positive for Epstein-Barr virus were Type-2 according to WHO, while 4 (9.8%) were Type-1. All three patients (100%) with Human Papillomavirus positivity were Type-2 according to WHO. Conclusions This study shows the close association between nasopharyngeal cancer and Epstein-Barr virus whereas such an association is not shown for Human Papillomavirus.Öğe Generalized fixed drug eruption in a child due to trimethoprim/sulfamethoxazole(Wiley-Blackwell, 2014) Can, Ceren; Akkelle, Emre; Bay, Bade; Arican, Ozer; Yalcin, Omer; Yazicioglu, Mehtap[Abstract Not Available]Öğe The histopathological comparison of L-carnitine with amifostine for protective efficacy on radiation-induced acute small intestinal toxicity(Medknow Publications, 2012) Caloglu, Murat; Caloglu, Vuslat Yurut; Yalta, Tulin; Yalcin, Omer; Uzal, CemBackground: The aim of the study was to compare the protective efficacy of l-carnitine (LC) to amifostine on radiation-induced acute small intestine damage. Materials and Methods: Thirty, 4-week-old Wistar albino rats were randomly assigned to four groups - Group 1: control (CONT, n = 6), Group 2: irradiation alone (RT, n = 8), Group 3: amifostine plus irradiation (AMIRT, n = 8), and Group 4: l-Carnitine plus irradiation (LCRT, n = 8). The rats in all groups were irradiated individually with a single dose of 20 Gy to the total abdomen, except those in CONT. LC (300 mg/kg) or amifostine (200 mg/kg) was used 30 min before irradiation. Histopathological analysis of small intestine was carried out after euthanasia. Results: Pretreatment with amifostine reduced the radiation-induced acute degenerative damage (P = 0.009) compared to the RT group. Pretreatment with LC did not obtain any significant difference compared to the RT group. The vascular damage significantly reduced in both of the AMIRT (P = 0.003) and LCRT group (P = 0.029) compared to the RT group. The overall damage score was significantly lower in the AMIRT group than the RT group (P = 0.009). There was not any significant difference between the LCRT and RT group. Conclusions: Amifostine has a marked radioprotective effect against all histopathological changes on small intestinal tissue while LC has limited effects which are mainly on vascular structure.Öğe Huge solitary primary pelvic hydatid cyst presenting as an ovarian malignancy: case report(Galenos Yayincilik, 2009) Aybatli, Aysun; Kaplan, Petek Balkanli; Yuce, Mehmet Ali; Yalcin, OmerHydatid disease is a zoonotic parasitic infection caused by Echinococcus granulosus. Echinococcus cysts are found mostly in the liver (60%) and lung (15%), but they can be located in any part of the body. However pelvic echinococcosis as the primary site is rarely seen. We report the case of a large echinococcal cyst localized in the lower pelvis. A 76-year-old woman was admitted to an emergency department with urinary retention for ten days. Ultrasonography and other imaging modalities revealed a mass with solid and cystic components in pelvic localization. This unusual presentation in an elderly postmenopausal woman was initially considered as an ovarian malignancy until surgical exploration and microscopic studies confirmed the diagnosis of echinococcosis. Antihelminthics were administered postoperatively and the patient is now being closely followed up. Gynecologists should be aware of the possibility of a primary hydatid cyst of the pelvic cavity and should be considered in the differential diagnosis of cystic pelvic masses, especially in areas where the disease is endemic.Öğe Importance of p53, bcl-2, p21WAF1 and PCNA positivities in renal angiomyolipomas(Allied Acad, 2017) Budak, Metin; Yalcin, Omer; Usta, Ufuk; Tokuc, BurcuAngiomyolipomas are tumors of the kidneys which are often benign in character with a potential for malignant transformation. The benign-malign distinction in these tumors can be made only with clinical follow-up as they exhibit the same microscopic appearance. In the present study, immunohistochemical investigation has been performed for p53, p21(WAF1), PCNA and bcl-2, which may be markers for the histological distinction of benign and malignant cases. The p53, p21WAF1, PCNA and bcl-2 investigations in 10 tumor tissues with AML revealed significantly higher p53 positivity in 3 patients. The clinical follow-up of these three patients showed malignant progression. In conclusion, we believe that p53 positivity may be an appropriate marker for the benign-malign distinction in AML tumors.Öğe L-Carnitine Ameliorates Glycerol-Induced Myoglobinuric Acute Renal Failure in Rats(Taylor & Francis Ltd, 2009) Ustundag, Sedat; Sen, Saniye; Yalcin, Omer; Ciftci, Senturk; Demirkan, Bora; Ture, MevlutThere is increasing evidence indicating that oxidative stress plays an important role in the pathogenesis of rhabdomyolysis-induced myoglobinuric acute renal failure (ARF). During times of war and natural disasters, myoglobinuric ARF can assume epidemic proportions. Thus, early and effective renoprotective treatments are of utmost importance. It has been shown that L-carnitine, used as a safe and effective nutritional supplement for more than three decades, is effective in preventing renal injury in many renal injury models involving oxidative stress. The present study was performed to investigate the effects of L-carnitine in an experimental model of myoglobinuric ARF. Four groups of rats were employed in this study: group 1 served as a control; group 2 was given glycerol (10 mL/kg, i.m.); group 3 was given glycerol plus L-carnitine (100 mg/kg, i.p.), starting at the same time as the glycerol injection; group 4 was given glycerol plus L-carnitine (100 mg/kg, i.p.), starting 48h before the glycerol injection. After glycerol injections, the i.p. injections of L-carnitine were repeated every 24h for four days. Ninety-six hours after glycerol injections, blood samples and kidney tissues were taken from the anesthetized rats. Urea and creatinine levels in plasma, N-acetyl-beta-D-glucosaminidase activity in urine, and malondialdehyde levels and catalase enzyme activity in kidney tissue were determined. Histopathological changes and iron accumulation in the kidney tissue were evaluated. In this study, glycerol administration led to marked renal oxidative stress, as well as severe functional and morphological renal deterioration. L-carnitine, possibly via its antioxidant properties, ameliorates glycerol-induced myoglobinuric kidney injury.Öğe Metachronous primary cutaneous malignant melanoma in a patient with laryngeal carcinoma(Kare Publ, 2011) Gorgulu, Adnan; Piskin, Suleyman; Gursel, Yildiz; Yalcin, Omer; Karagol, HakanMultiple primary tumors have long been considered as a feature of laryngeal carcinoma. The most common sites of primary tumors appearing during the course of laryngeal carcinoma were, in order, the lung, mouth and oropharynx. However, primary cutaneous neoplasm reported during the course of laryngeal carcinoma occurs very rarely. We report a case of primary cutaneous malignant melanoma that developed during the follow-up of a 43-year-old male with primary laryngeal carcinoma. We review the literature with these recent developments.
