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  • Küçük Resim Yok
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    Akut solunum sıkıntısı yapan kombine larengopyosel ve trakeotomisiz tedavisi
    (1999) Uzun, Cem; Koten, Muhsin; Adalı, Mustafa K.; Karasalihoğlu, Ahmet R.; Şahin, Oğuz B.; Özel, Serhan E.
    Enfekte larengosele larengopyosel denir ve oldukça nadir görülür. Özellikle internal komponenti olanlar, akut solunum yolu tıkanıklığına yol açabilir. Acil medikal tedavi ile, trakeotomiye gerek kalmayabilir. Bu makalede, kombine larengopyoselli 52 yaşında bir erkek hasta ve tedavisi sunulmuştur. Akut solunum sıkıntısı ve boyunda şişlik şikayetiyle başvuran hastaya, oksijen, intravenöz antibiyotik ve steroid tedavisi uygulandı. Bu tedavi sonucu, solunum sıkıntısı kısa sürede hafifledi, trakeotomi gerekmedi. Lezyon eksternal yaklaşımla çıkarıldı. Altı aylık izlemde, şu ana kadar herhangi bir nüks ve karsinom gelişimi saptanmadı.
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    Ani işitme kayıpları hastaların transkraniyal doppler ultrasonografi ile değelendirilmesi
    (2006) Asil, Talip; Karasalihoğlu, Ahmet R.; Yağız, Rcep; Uzun, Cem; Taş, Abdullah; Şan, Haldun
    Amaç: Vasküler patolojiyi belirleme açısından, ani işitme kayıplı olguların değerlendirilmesinde transkraniyal Doppler ultrasonografinin yeri araştırıldı. Hastalar ve Yöntemler: Ani işitme kaybı tanısı konmuş 13 hasta (11 erkek, 2 kadın; ort. yaş 46.6±17.7; dağılım 18-66) çalışmaya alındı. Kronik otitis media, diğer orta kulak hastalıkları ve kulak ameliyatı öyküsü olan hastalar çalışma dışı bırakıldı. Bütün hastalara saf ses odyometri, impedans odyometrisi, transient evoked otoakustik emisyon, işitsel beyin sapı yanıtları ve transkraniyal Doppler ultrasonografi yapıldı. Kontrol grubu, kulak hastalığı, gürültülü yerde çalışma ve ototoksik ilaç kullanma öyküsü olmayan, otoskopik ve odyometrik değerlendirmede patoloji saptanmayan, hasta grubuyla yaş ve cinsiyet bakımından farklılık bulunmayan sağlıklı 19 bireyden (12 erkek, 7 kadın; ort. yaş 46.8±6.9; dağılım 33-58) oluşturuldu. Bulgular: Ani işitme kayıplı olguların hasta tarafta vertebral arter ortalama akım hızı ve sistolik akım hızı ortalamaları sağlam tarafa göre istatistiksel olarak anlamlı derecede düşük, pulsatil indeks ortalaması ise yüksek bulundu. Çalışma grubunda, baziler arter ortalama akım hızı kontrol grubuna göre düşük bulundu. Sonuç: Transkraniyal Doppler ultrasonografi ani işitme kayıplı olgularda vertebral ve baziler arter sistemindeki vasküler etkilenmeyi değerlendirme amacıyla kullanılabilir.
  • Küçük Resim
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    Araştırmalarda Cinsiyet ve Toplumsal Cinsiyet Eşitliği: Sager Yönergelerinin Gerekçesi ve Kullanım Önerisi
    (Trakya Üniversitesi, 2020) Atakan, Müge; Uzun, Cem
    Background: Sex and gender differences are often overlooked in research design, study implementation and scientific reporting, as well as in general science communication. This oversight limits the generalizability of research findings and their applicability to clinical practice, in particular for women but also for men. This article describes the rationale for an international set of guidelines to encourage a more systematic approach to the reporting of sex and gender in research across disciplines.Methods: A panel of 13 experts representing nine countries developed the guidelines through a series of teleconferences, conference presentations and a 2-day workshop. An internet survey of 716 journal editors, scientists and other members of the international publishing community was conducted as well as a literature search on sex and gender policies in scientific publishing.Results: The Sex and Gender Equity in Research (SAGER) guidelines are a comprehensive procedure for reporting of sex and gender information in study design, data analyses, results and interpretation of findings.Conclusions: The SAGER guidelines are designed primarily to guide authors in preparing their manuscripts, but they are also useful for editors, as gatekeepers of science, to integrate assessment of sex and gender into all manuscripts as an integral part of the editorial process.
  • Küçük Resim Yok
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    Assessment of visualization of structures in the middle ear via Tos modified canal wall-up mastoidectomy versus classic canal wall-up and canal wall-down mastoidectomies
    (Elsevier Ireland Ltd, 2007) Uzun, Cem; Kutoglu, Tunc
    Objective: The aim of this prospective study is to evaluate the differences in the ability to view structures in the middle ear between Tos modified canal watt-up mastoidectomy and classic canal wall-up (CWU) and canal wall-down (CWD) mastoidectomies. Methods: Eighteen temporal bones of 10 cadaver heads were used. Six bones were randomly selected for each surgicat technique (Tos' technique, CWU and CWD mastoidectomies) and fixed on an operating table. In the Tos' technique: (1) transmeatal posterior tympanotomy with drilling of the supero-posterior bony annulus, (2) transmeatal atticotomy with preservation of the bony bridge and (3) cortical mastoidectomy were performed. In the classic CWU mastoidectomy, cortical mastoidectomy and posterior atticotympanotomy (faciat recess approach) were performed. Incus and posterior half of the tympanic membrane were removed from all temporal bones. An independent specialist performing otologic surgery evaluated all of the temporal bones and approved the proper extent of dissections. Two another independent observers blinded to the purpose of the study were asked to point five anatomic structures and locations (sinus tympani, anterior attic, posterior crus, lateral attic and the Eustachian tube orifice) in two different sessions. Observers were allowed to rotate the operating table as it has been done during otologic surgery, and the line of view for the observers was both transmastoid and transcanal. The ability to view these structures was recorded as correct /visible or incorrect/invisible. These records were also verified after removing the posterior and superior walls of the outer ear canal in temporal bones of the Tos and CWU groups at the end of the study. Results: Significant differences were found in the ability to view middle ear structures between the Tos' technique and CWU mastoidectomy as well as between CWU and CWD mastoidectomies, with the Tos' and CWD techniques almost equally showing superiority to CWU (p < .0001). Of the five locations, sinus tympani and anterior attic were observed more frequently with the Tos' technique versus CWU (p = .001). Sinus tympani (p < .005), anterior attic (p = .001) and posterior crus (p < .05) were observed more frequently with CWD versus CWU. There was no significant difference in the ability to observe Lateral attic and the Eustachian tube orifice among the three techniques. In addition, there was no significant difference in the ability to visualize all the five locations between the Tos' and CWD technique. Conclusions: Statistical analysis showed good reproducibility of this randomised, blinded study. Tos' modified CWU mastoidectomy, in which most part of the canal wall is intact, showed similar advantage of the CWD in viewing structures in the middle ear. The Tos' technique and CWD mastoidectomy provided better visualization of sinus tympani and anterior attic that are the most frequent places of residual cholesteatoma in the classic CWU mastoidectomy. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
  • Küçük Resim
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    Balkan Medical Journal and Legal Regulation
    (2019) İnan, Mustafa; Erbaş, Hakan; Koçak, Zafer; Uzun, Cem
    [Abtract Not Available]
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    Balkan Medical Journal is Now a Member of Committee on Publication Ethics
    (Galenos Publ House, 2013) Uzun, Cem
    [Abstract Not Available]
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    Cochlear Implant Surgery Experiences of a Tertiary Health Center in the Thrace Region
    (Galenos Publ House, 2022) Guven, Selis Gulseven; Uzun, Cem; Tas, Memduha; Demir, Erbay
    Aim: Cochlear implants (CIs) aid in language and speech development through improved hearing in patients with bilateral severe or profound hearing loss. In this study, we evaluated the outcomes of our patients undergoing CI surgery. Materials and Methods: Preoperative, perioperative and postoperative clinical and audiological findings, hearing loss etiology, surgical approach techniques, and complications were evaluated retrospectively in 31 patients (35 ears) undergoing CI surgery. Results: Thirty one patients (13 adults and 18 children) were included in the study. After posterior tympanotomy following cortical mastoidectomy, electrodes were introduced through the round window in 21 ears and via cochleostomy in 14 ears. CIs with different number of electrodes (22, 16, 12) from 3 different companies were used. No postoperative complications were observed in any of the patients. The mean free field audiogram (FFA) was 95.2 +/- 19.13 dB preoperatively and 37.8 +/- 8.46 dB postoperatively in 24 patients who attended the control visits. Postoperative hearing gains were significantly different from the preoperative values (p<0.001). There was no significant difference between different devices (p=0.340). Electrodes were introduced through the round window or by cochleostomy, and comparison of these two groups revealed no statistically significant difference in terms of postoperative FFA values (p=0.425) or speech awareness threshold and speech reception threshold values (p=0.132). Conclusion: The significant hearing gains in the postoperative period without any complications indicate the success of the surgical technique utilized in this study. It can be said that the difference in electrode insertion location and numbers does not affect the postoperative results.
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    DNA methylation of the prestin gene and outer hair cell electromotile response of the cochlea in salicylate administration
    (Tubitak Scientific & Technological Research Council Turkey, 2017) Bulut, Erdogan; Budak, Metin; Ozturk, Levent; Turkmen, Mehmet T.; Uzun, Cem; Sipahi, Tammam
    Background/aim: Activity of the prestin gene may have a role in the pathogenesis of salicylate-induced ototoxicity. We investigated DNA methylation for prestin gene exon 1 in salicylate-injected guinea pigs. Materials and methods: Fifteen guinea pigs (30 ears) underwent audiological evaluation including 1000 Hz probe-tone tympanometry and a distortion product otoacoustic emission (DPOAE) test. The animals were randomly divided into three groups. Groups 2 (8 ears) and 3 (14 ears) were injected with intramuscular saline and sodium salicylate (200 mg/kg), respectively twice daily for 2 weeks. Group 1 (8 ears) received no injection. DPOAE measurements were performed at baseline; after 1, 2, 4, and 8 h (acute effect); and after 1 and 2 weeks (chronic effect). After audiological measurements, the animals were sacrificed for DNA isolation. Results: While a significant decrease (P < 0.01) was found for the acute effect in all frequencies in Group 3 according to baseline measurements, there was no difference in terms of chronic effect. DNA methylation increased during the acute phase of salicylate administration, whereas it returned to initial levels during the chronic phase. Conclusion: Salicylate-induced changes in DPOAE responses may be related to prestin-gene methylation. These results may have important implications for salicylate ototoxicity.
  • Küçük Resim Yok
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    DNA methylation of the prestin gene and outer hair cell electromotileresponse of the cochlea in salicylate administration
    (2017) Bulut, Erdoğan; Budak, Metin; Öztürk, Levent; Türkmen, Mehmet T.; Uzun, Cem; Sipahi, Tammam
    Background/aim: Activity of the prestin gene may have a role in the pathogenesis of salicylate-induced ototoxicity. We investigated DNA methylation for prestin gene exon 1 in salicylate-injected guinea pigs. Materials and methods: Fifteen guinea pigs (30 ears) underwent audiological evaluation including 1000 Hz probe-tone tympanometry and a distortion product otoacoustic emission (DPOAE) test. The animals were randomly divided into three groups. Groups 2 (8 ears) and 3 (14 ears) were injected with intramuscular saline and sodium salicylate (200 mg/kg), respectively twice daily for 2 weeks. Group 1 (8 ears) received no injection. DPOAE measurements were performed at baseline; after 1, 2, 4, and 8 h (acute effect); and after 1 and 2 weeks (chronic effect). After audiological measurements, the animals were sacrificed for DNA isolation. Results: While a significant decrease (P < 0.01) was found for the acute effect in all frequencies in Group 3 according to baseline measurements, there was no difference in terms of chronic effect. DNA methylation increased during the acute phase of salicylate administration, whereas it returned to initial levels during the chronic phase. Conclusion: Salicylate-induced changes in DPOAE responses may be related to prestin-gene methylation. These results may have important implications for salicylate ototoxicity.
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    Does noise exposure during pregnancy affect neonatal hearing screening results?
    (Wolters Kluwer Medknow Publications, 2019) Guven, Selis Gulseven; Tas, Memduha; Bulut, Erdogan; Tokuc, Burcu; Uzun, Cem; Karasalihoglu, Ahmet Karasalihoglu
    Objective: The aim is to investigate whether noise is effective on hearing screening tests of neonates born to mothers exposed to noise during pregnancy. Material and Method: Screening results of 2653 infants from the period of January 2013-May 2017 were evaluated. Transient Evoked Otoacoustic Emissions (TEOAE) and Auditory Brainstem Response (ABR) were used. Infants of 65 mothers exposed to noise (LAeq 80-85 dBA/8 hours/day) during pregnancy (Week +/- SD; 32.58 +/- 2.71) comprised the study group while the control group consisted of infants of 2588 mothers without noise exposure. Results: Among the 65 infants, 23 (35.4%) passed screening at the first emission test (OAE1); 34 (52.3%) at the second emission test (OAE2); 7 (10.8%) at the ABR stage, 1 (1.5%) infant was referred to a tertiary center. In the control group, 458 (17.7%) infants passed at OAE1; 1822 (70.4%) at OAE2; 289 (11.2%) at ABR stages, 19 (0.7%) infants were referred to a tertiary center. The rate of infants that passed screening at OAE1 in the study group was high (P = 0.00001). Sixty-four (98.46%) infants in the study group and 2569 (99.26%) infants in the control group passed the tests. The difference between the two groups was not significant, indicating that exposure to noise during pregnancy had no unfavorable effects on auditory functions (P = 0.392). Conclusion: Unfavorable effect of noise exposure during pregnancy was not observed on auditory functions of the infants. The higher rate of infants that passed the screening test at OAE1 stage in the study group raised the question, Does the exposure of the noise at exposure action levels (80-85 dB A) during pregnancy contribute to auditory maturation of fetus?
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    Does Oral Monosodium Glutamate Have a Cochleotoxic Effect? An Experimental Study
    (Karger, 2022) Guven, Selis Gulseven; Ersoy, Onur; Topuz, Ruhan Deniz; Bulut, Erdogan; Kizilay, Gulnur; Uzun, Cem
    Introduction: The effect of orally consumed monosodium glutamate (MSG), which is a common additive in the food industry, on the cochlea has not been investigated. The present study aimed to investigate the possible cochleotoxic effects of oral MSG in guinea pigs using electrophysiological, biochemical, and histopathological methods. Methods: Thirty guinea pigs were equally divided into control and intervention groups (MSG 100 mg/kg/day; MSG 300 mg/kg/day). At 1 month, 5 guinea pigs from each group were sacrificed; the rest were observed for another month. Electrophysiological measurements (distortion product otoacoustic emission [DPOAE] and auditory brainstem response [ABR]), glutamate levels in the perilymph and blood samples, and histopathological examinations were evaluated at 1 and 2 months. Results: Change in signal-to-noise ratio at 2 months was significantly different in the MSG 300 group at 0.75 kHz and 2 kHz (p = 0.013 and p = 0.044, respectively). There was no statistically significant difference in ABR wave latencies of the guinea pigs given MSG compared to the control group after 1 and 2 months; an increase was noted in ABR thresholds, although the difference was not statistically significant. In the MSG groups, moderate-to-severe degeneration and cell loss in outer hair cells, support cells, and spiral ganglia, lateral surface junction irregularities, adhesions in stereocilia, and partial loss of outer hair cell stereocilia were noted. Conclusion: MSG, administered in guinea pigs at a commonly utilized quantity and route of administration in humans, may be cochleotoxic.
  • Küçük Resim
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    Editor Responsibility and Scientific Integrity During the COVID-19 Outbreak
    (2020) Koçak, Zafer; Uzun, Cem
    [Abtract Not Available]
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    The Effect of Auricular Graft Donor Site on Morbidity and Cosmetic Appearance in Cartilage Tympanoplasties
    (Aves, 2020) Huseyinoglu, Aydin; Uzun, Cem; Koder, Ahmet; Yagiz, Recep; Benlier, Erol; Bulut, Erdogan
    OBJECTIVES: The aim of the present study was to compare the postoperative morbidity and cosmetic results between the use of the scapha and the use of the tragus as the auricular cartilage graft donor site in patients who had undergone cartilage tympanoplasty. The fascia graft was used as the control. MATERIALS and METHODS: The patient's visual symmetry, cosmetic satisfaction, and anthropometric measurements were studied to objectively evaluate the cosmetic condition. The formation of skin scar changes, pigmentation changes, and sensory changes as clinical criteria were compared. RESULTS: A total of 234 patients and their 257 operated ears were included in the study. Forty prospectively operated ears with preoperative findings were also included. All patients (100%) felt that their results were good, as indicated by the visual analog scale, and the anthropometric ear measurements used to reinforce the data showed no significant differences between the groups. A significant difference with respect to clinical sensory changes was found between the groups only in patients undergoing unilateral surgery via the retro auricular approach (p<0.05). There was no difference between the scapha and tragus groups with respect to scar formation or skin pigmentation change. CONCLUSION: Neither scapha nor tragus use for graft retrieval led to dissatisfaction or cosmetic problems in the postoperative period. Sensory changes in the skin on clinical evaluation were less common in patients in whom the scapha donor site was preferred than in cases in which the tragus was used.
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    Effects of sleep deprivation on anaerobic exercise-induced changes in auditory brainstem evoked potentials
    (Wiley, 2007) Oeztuerk, Levent; Bulut, Erdogan; Vardar, Selma Arzu; Uzun, Cem
    The present study was designed to assess how anaerobic exercise affects auditory brainstem response (ABR) parameters, and whether one night of sleep deprivation could alter these possible exercise-induced changes in ABRs. Seven healthy, audiologically normal male students (mean age 22.4 +/- 1.0 years) participated in the study. All subjects underwent anaerobic Wingate test for three times: (i) baseline, (ii) following a full-night of habitual sleep and (iii) following one night of sleep deprivation. ABR measurements were performed before and after the second and the third Wingate tests. Oral body temperatures were recorded at the beginning of all ABR measurements. The latencies of wave III and V significantly shortened by anaerobic loading performed in the day after habitual sleep (4.13 +/- 0.10 versus 4.01 +/- 0.17 ms, P < 0.02; and 5.84 +/- 0.26 versus 5.65 +/- 0.23 ms, P < 0.03, respectively). One night of total sleep deprivation shortened pre-exercise latencies and altered exercise-induced changes in ABRs. The findings obtained in the present study show that acute anaerobic exercise is effective on ABR wave latencies independent from body temperature changes, and sleep deprivation has some modulatory effects on exercise-induced changes in ABR.
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    Epiglot rekonstrüksiyonlu frontal anterior larenjektomi
    (2000) Karasalihoğlu, Ahmet R.; Uzun, Cem; Adalı, Mustafa Kemal; Koten, Muhsin; Küçükuğurluoğlu, Murat; Yağız, Recep; Taş, Abdullah
    Amaç: Epiglot rekonstrüksiyonlu frontal anterior larenjektomi yönteminin teknik özellikleri, endikasyonları, avantaj/dezavantajlar/ ve fonksiyonel sonuçlarını incelemek. Gereç ve Yöntem: 1985-1999 yılları arasında T1 b yada T2 glottik kanser nedeniyle epiglot rekonstrüksiyonlu frontal anterior larenjektomi operasyonu uygulanan 22 hasta fonksiyonel sonuçları açısından retrospektif olarak incelendi. Bulgular: Tüm hastalar ortalama 14,5 (en az 8, en çok 18) günde yutabilmiş ve ortalama 17,5 (en az 9, en çok 27) günde dekanülmanı tolere edebilmişlerdir. Takibi bırakan bir hasta dışında bütün hastalar hayatta olup hiçbir hastada nüks gelişmemiştir. Takibi bırakan bu hasta ölmüş kabul edilirse, tümör kontrolü T1b lezyonlu hastalarda % 100, T2 lezyonlu hastalarda %89, 5 yıllık sağ kalım oranı T1b lezyonlu hastalarda %100 (n=7), T2 lezyonlu hastalarda %83 (n=6) dür. Hastaların hepsi telefonda dahi iletişim kurabilecek bir konuşmaya sahiptir. Sonuç: Epiglot rekonstrüksiyonlu frontal anterior larenjektomi, tek seanstı bir teknik oluşu, yaşlı ve genel durumu elverişli olmayan hastalarda da uygulanabilmesi ve fonksiyonel sonuçlarının olumlu olması nedeniyle ön komüssür rezeksiyonu gereken T1b ve T2 glottik kanserlerde etkin bir tedavi yöntemi olduğu kanısındayız.
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    Evaluation of hearing in children with autism by using TEOAE and ABR
    (Sage Publications Ltd, 2007) Tas, Abdullah; Yagiz, Recep; Tas, Memduha; Esme, Meral; Uzun, Cem; Karasalihoglu, Ahmet Rifat
    Assessment of auditory abilities is important in the diagnosis and treatment of children with autism. The aim was to evaluate hearing objectively by using transient evoked otoacoustic emission (TEOAE) and auditory brainstem response (ABR). Tests were performed on 3 0 children with autism and 15 typically developing children, following otomicroscopy and tympanometry. The children with autism were sedated before the tests. Positive emissions and normal hearing level at ABR were obtained in both ears of all children in the control group and of 25 children with autism. TEOAE and ABR results varied in the remaining five children with autism. The mean III-V interpeak latencies (IPLs) in both ears of children with autism were longer than those in the control group. Hearing loss may be more common in children with autism than in typically developing children.
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    Frontal anterior laryngectomy with epiglottic reconstruction (Tucker's operation): Oncologic and functional results
    (2012) Yağız, Recep; Taş, Abdullah; Uzun, Cem; Adalı, Mustafa Kemal; Koten, Muhsin; Çiftçi, Elif; Karasalihoğlu, Ahmet Rıfat
    Amaç: Epiglot rekonstrüksiyonlu frontal anterior larenjektomi (Tucker operasyonu) ile tedavi edilen hastaların fonksiyonel ve onkolojik sonuçlarını değerlendirmek. Hastalar ve Yöntemler: Eylül 1985-Kasım 2009 yılları arasında, erken glottik tümörü olan 58 hastaya Tucker operasyonu uygulandı. Dekanülasyon zamanı, nazogastrik sondanın çıkarılması, hastanede yatış ve onkolojik sonuçlar analiz edildi. Akustik analiz ve Ses Handikap Endeksi (SHE) vokal fonksiyon değerlendirmesi için kullanıldı. Bulgular: Ortalama dekanülasyon ve nazogastrik sonda çıkarılma süreleri sırasıyla 11,8 ve 15,4 gündü. Ortalama hastanede yatış süresi 19,3 gündü. Erken dekanülasyon uygulamasının hastaların dekanülasyon ve hastanede yatış sürelerini belirgin şekilde azalttığı bulundu. Beş yıllık genel sağ kalım oranı %81,5, primer hastalığa spesifik sağ kalım oranı %96,9 bulundu. On yıllık genel ve primer hastalığa spesifik sağ kalım oranları sırasıyla %67 ve %95,2 bulundu. Beş yıllık lokal kontrol oranı %95,4, nodal kontrol oranı %95,2 bulundu. Hastaların jitter, shimmer ve gürültü-harmonik oranı sırasıyla %8,1, %16,6 ve 0.51 bulundu. Bu değerler belirgin bir artışı gösteriyordu. Total SHE skoru ve alt grup skorlarından SHE-emosyonel hariç diğerleri hastaların hafif düzeyde ses sorunu yaşadığını gösterdi. Sonuç: Tucker operasyonu yüksek onkolojik ve tatminkar fonksiyonel sonuçlarıyla erken glottik karsinomların tedavisinde tercih edilebilecek tekniklerden biridir.
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    Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi
    (2006) Yıldırım, Çetin; Uzun, Cem; Karasalihoğlu, Ahmet Rifat; Yağız, Recep; Taş, Abdullah; Bulut, Erdoğan
    Kobaylarda gürültüye bağlı koklear hasarın ön­lenmesinde magnezyumun koruyucu etkisi transient evoked otoacoustic emission (TEOAE) kullanılarak araştırıldı. Çalışma Planı: Normal auropalpebral refleksli 39 yetiş­kin kobay rastgele yöntemle kontrol (n=20) ve deney (n=19) gruplarına ayrıldı. Tüm kobaylara ses yalıtımlı ka­binde, ortamdaki gürültü düzeyi ortalama 98±2 dB ola­cak şekilde, 10 gün süreyle günde 16 saat wide-band gürültü uygulandı. Deney grubundaki kobaylara, gürültü uygulamasından 15 gün önce oral yoldan 39 mmol/l MgCI2 verilmeye başlandı ve gürültü sonrası ölçümler ta­mamlanana kadar sürdürüldü. Gürültü uygulaması önce­si ve sonrasında her iki grupta otomikroskopik muayene, işitsel beyin sapı yanıtları (ABR) ve TEOAE ölçümleri ya­pıldı. Anormal bulgu saptanan kulaklarda orta kulak pa­tolojisini elemek için timpanometri yapıldı. Bulgular: Kontrol grubunda, TEOAE response ve reprodüktibilite ortalamaları gürültü sonrasında anlamlı düşüş gösterirken (p<0.001), deney grubunda bu de­ğerlerin anlamlı farklılık göstermediği görüldü. İki grup arasında, gürültü sonrası response ve reprodüktibilite değerleri açısından anlamlı farklılık bulundu (p<0.001). Her iki grupta da ABR eşik düzeyleri gürültü öncesine göre anlamlı yükselme göstermesine karşın (p<0.001), deney grubunda işitme eşiklerinin daha fazla korundu­ğu saptandı (p<0.001). Sonuç: Bulgularımız, gürültüye bağlı oluşan koklear hasarın önlenmesinde oral magnezyum tedavisinin et­kili olabileceğini düşündürmektedir.
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    Increasing the Impact Factor in the Ethical Way
    (Galenos Publ House, 2017) Uzun, Cem
    [Abstract Not Available]
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    Intracranial Complications of Chronic Suppurative Otitis Media
    (Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2008) Yagiz, Recep; Adali, Mustafa Kemal; Tas, Abdullah; Uzun, Cem; Koten, Muhsin; Karasalihoglu, Ahmet
    Objectives: To evaluate the clinical signs and symptoms, diagnosis-treatments, distributions and outcomes of patients with intracranial complications due to chronic suppurative otitis media (CSOM). Patients and Methods: Data of 42 patients (27 males, 15 gemales; mean age 31.3 years; range 9 to 74 years) diagnosed as intracranial complication due to CSOM were reviewed retrospectively. Patients were investigated on the basis of age, sex, symptoms, findings of otoscopic examination, complications, radiological evaluations, methods of management and findings at the operation. Results: Complications occurred predominantly in patients between 31 and 40 years of age (33.3%). Severe headache, nausea-vomiting, otalgia, purulent otorrhea and fever were the most common signs and symptoms. Meningitis was the most common (115 patients, 35.7%), brain abscess (14 patients, 33.3%) and lateral sinus thrombosis (10 patients, 23.8%) were second and third common complications. The overall mortality rate was 2.4% (in one patient who was comatose on admission), whereas it was 7.1% for patients with brain abscess. Conclusion: Intracranial complications of CSOM are still a serious problem due to life-threatening condition. If a patient with active CSOM has severe headache, nausea-vomiting, otalgia and fever, otogenic intracranial complication should be considered, and detailed evaluation should be performed for early diagnosis since the level of consciousness on admission is an important prognostic factor.