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Öğe Distal sensorimotor polyneuropathy affects skeletal muscle perfusion and metabolism by Tc-99m sestarnibi leg scintigraphy in patients with type 2 diabetes(Lippincott Williams & Wilkins, 2005) Ugur-Altun, B; Durmus-Altun, G; Ustun, F; Turgut, N; Altun, A; Tugrul, AWe evaluated the effects of distal symmetric sensorimotor polyneuropathy (DSP) on skeletal muscle perfusion and metabolism in patients with type 2 diabetes. Twenty-three patients with type 2 diabetes under-went electrophysiological and Tc-99m sesta-mibi leg scintigraphic studies. The study patients were divided into 2 groups: group I (n = 14) with DSP and group 11 (n = 9) without DSP. We found decreased Tc-99m sestamibi uptake ratios (UR) of both legs in patients with DSP (right UR 7.98 +/- 6.85, left UR 7.78 +/- 7.01 vs. right UR 8.91 +/- 7.98, left UR 8.67 +/- 8.23, respectively) than without DSP, although it did not reach statistical significance. The regression equation of right UR was (Tc-99m sestarnibi UR = [1.927 X velocity of tibial nerve] - [0.942 X amplitude of sural nerve] - 81.94). In conclusion, electrophysiological variables of tibial motor and sural sensory nerves predict Tc-99m sestarnibi UR at leg scintigraphy in patients with type 2 diabetes. Additionally, decreased Tc-99m sestarnibi UR in patients with type 2 diabetes with DSP was found.Öğe Evaluation of morphine effect on tumour angiogenesis in mice breast tumour by using 99mTc-Tetrofosmin scintigraphy(Springer, 2004) Ustun, F; Durmus-Altun, G; Tuncbilek, N; Altaner, S; Uzal, MC; Berkarda, S[Abstract Not Available]Öğe Extensive bone metastases in a patient with prostatic adenocarcinoma and normal serum prostate-specific antigen and prostatic acid phosphatase(Lippincott Williams & Wilkins, 2001) Yuksel, M; Çermik, TF; Kaya, M; Salan, A; Ustun, F; Salihoglu, YS; Yigitbasi, ÖN[Abstract Not Available]Öğe High bone mineral density in loaded skeletal regions of former professional football (soccer) players: what is the effect of time after active career?(B M J Publishing Group, 2005) Uzunca, K; Birtane, M; Durmus-Altun, G; Ustun, FObjectives: Physical exercise is an important factor in the acceleration and maintenance of bone mineral density (BMD). Football is an impact loading sport and some studies demonstrate its site specific, bone mass increasing effect. We compared BMD at different skeletal regions in a group of former professional football players and in normal control subjects and evaluated the effect of demographic factors and time after active career on BMD. Methods: Twenty four former football players,70 years old who had retired from professional football at least 10 years previously and 25 non- athletic controls were recruited. The demographic characteristics, activity levels, and dietary habits of all subjects and the chronological history of the footballers' professional careers were noted. BMD was measured by DEXA at the calcaneus and distal tibia and at the lumbar spine, proximal femur, and distal and proximal radius, and compared between groups. Stepwise multiple linear regression analysis was used to determine the probable predictors of BMD in former football players. Results: In former players BMD values were found to be significantly higher at the lumbar spine, femur neck, femur trochanter, distal tibia, and calcaneus, but not at Ward's triangle ( femur) or the distal and proximal radius regions compared with controls. Time after active career was the only independent predictor of BMD at the lumbar spine, proximal femur ( neck, trochanter, and Ward's triangle), and distal tibia. Conclusions: Former footballers had higher BMD at weight loaded sites and time after active career seemed to be an important factor in determining BMD.Öğe The incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991-2003(Springer, 2005) Ustun, F; Yuksel, M; Durmus-Altun, G; Kaya, M; Çermik, TF; Sarikaya, A; Berkarda, SObjective: The purpose of this retrospective study was to evaluate the incidence of recurrence and the success of radioiodine treatment (RIT) in the Trakya region of Turkey, an area with mild iodine deficiency, and to compare the effect of dose regimen selection (fixed (FD) or calculated dose (CD)) on treatment success. Material and Methods: The study sample included 148 patients (40 male, median age 50) treated with radioiodine between the years 1991-2003. Patients were categorized into three diagnostic groups: Graves' disease (GD) (n = 65), solitary toxic adenoma (TA) (n = 29), and toxic multinodular hyperthyroidism (TMH) (n = 54), and each divided into two subgroups according to treatment method; the first group was treated with a FD of 370 MBq (10 mCi), and the second with CD. Results: The largest group was GD (44%), followed by TMH (36%). Median duration of follow-up was 28 months (range 6-147). FD was given to 52.7% of all patients and CD was given to 47.3%. There was a partial difference in the dose regimen between all groups, but did not reach statistically significant levels (FD vs. CD: 65%-35%; 38%-62%; 46%-54%; GD, TA, TMH respectively, p > 0.05). Total cure rate in FD and CD was 46 (59%) and 37 (52.9%), respectively. The rates of hypothyroidism for GD, TA, and TMH groups were 28 (43.1%), 6 (20.7%) and 16 (29.6%), respectively. The incidence of hypothyroidism did not vary significantly between any groups (p > 0.05). At the end of the follow-up period, a total of 104 patients (70.3%) were treated successfully. There was no significant difference in the cure rate between any groups (p > 0.05). Conclusions: The treatment success in all groups and subgroups did not differ significantly between FD and CD. Our lower cure rate than in previous studies may be related to iodine deficiency. Higher doses of radioiodine may be required to increase final treatment success in endemic goiter areas. If this true, dosimetry and calculated dose regimen would be required in all groups of patients instead of an FD concept. However, our findings should be verified in larger series of patients, with longer follow-up period, and urinary iodine concentration measurements.Öğe Incidental diagnosis of asymptomatic pericardial effusion in uraemic patient by using 99mTc-MIBI perfusion SPEG(Schattauer Gmbh-Verlag Medizin Naturwissenschaften, 2003) Durmus-Altun, G; Ustun, F; Altun, A; Ustundog, S[Abstract Not Available]Öğe Technetium-99m sestamibi cavity/myocardium count ratio in the detection of left ventricular hypertrophy(Clinical Cardiology Publ Co, 2003) Altun, GD; Akdemir, O; Ustun, F; Altun, A; Sarikaya, A; Berkarda, SBackground and hypothesis: Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular mortality and morbidity. This study was designed to assess whether technetium-99m (Tc-99m) sestamibi cavity-to-myocardium count (c/m) ratio would differentiate LVH from normal geometry, and discriminate between the two patterns-concentric and eccentric-of LVH. Methods: In all, 72 patients including 32 hypertensive patients with both normal Tc-99m sestamibi single-photon emission computed tomography imaging and good-quality echocardiographic recordings were studied retrospectively. Four different patterns of left ventricular (LV) geometry were defined: normal (n = 47), concentric remodeling (n = 3), eccentric LVH (n = 13), and concentric LVH (n = 9). Results: Left ventricular hypertrophy was detected in 22 of 32 hypertensive patients. The c/m ratio calculated on midventricular short-axis slices of dipyridamole-stress Tc-99m sestamibi images was significantly decreased in patients with LVH compared with subjects with normal geometry (0.05 +/- 0.02 vs. 0.17 +/- 0.08, p = 0.001). A c/m ratio of < 0.124 yielded a sensitivity of 86%, a specificity of 64%, and an overall diagnostic accuracy of 68% for detecting LVH. Negative correlations of c/m ratio were found to LV mass-index (r = -0.44, p = 0.004), septal width (r = -0.42, p = 0.008), posterior wall thickness (r = -0.39, p = 0.001), and relative wall thickness (r = -0.40, p = 0.001). Multiple linear regression analysis revealed that LV mass index was the single independent predictor of c/m ratio. Although both groups with concentric and eccentric LVH had a significantly lower mean c/m ratio than those with normal geometry (p = 0.01 and p = 0.01, respectively), no significant difference of c/m ratio was found between the two patterns of LVH. Conclusion: A new index, c/m ratio on Tc-99m sestamibi images, has a potential to discriminate between LVH and normal geometry in subjects free of myocardial ischemia.