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Öğe Headache response to nitrate in patients with coronary artery disease and systolic heart failure(Elsevier Ireland Ltd, 2012) Sivri, Nasir; Tekin, Gulacan; Erbay, Ali Riza; Yalta, Kenan; Senen, Kubilay; Guer, Mustafa; Yetkin, Ertan[Abstract Not Available]Öğe Mean Platelet Volume in Patients With Dilated Cardiomyopathy: Does it have a Role in Left Ventricular Thrombus Formation?(Sage Publications Inc, 2012) Tekin, Gulacan; Sivri, Nasir; Tekin, Yusuf Kenan; Topal, Ergun; Erbay, Ali Riza; Yetkin, ErtanWe assessed the clinical echocardiograhic, hematological, and biochemical parameters in patients with dilated cardiomyopathy (DCMP) and control individuals mainly focusing on the mean platelet volume (MPV) in terms of DCMP and left ventricle (LV) thrombus formation. Consecutive patients (n = 251) with DCMP and 266 patients without DCMP were studied. Mean platelet volume was significantly greater in patients with DCMP than in control patients (P < .05 for all comparisons). Comparing DCMP patients with LV thrombus (19 patients, 8%) and without LV thrombus (232 patients, 92%) showed that the prevalence of smokers was significantly higher and ejection fraction was significantly lower in patients with LV thrombus. We have shown that patients with DCMP have significantly higher MPV suggesting more platelet activation and the MPV of patients with DCMP and LV thrombus is comparable to those of patients without LV thrombus.Öğe Mean platelet volume in patients with nonvalvular atrial fibrillation(Lippincott Williams & Wilkins, 2013) Tekin, Gulacan; Tekin, Yusuf Kenan; Sivri, Nasir; Yetkin, ErtanThe procoagulant and prothrombotic states in patients with chronic atrial fibrillation are higher than those in patients with normal sinus rhythm. Mean platelet volume (MPV) which is a marker of platelet function and activation can reflect changes either in the level of platelet stimulation or the rate of platelet production. In this study, we aimed to assess and compare the hematologic parameters of routine complete blood count analysis in elderly patients with nonvalvular atrial fibrillation and control individuals with normal sinus rhythm. One hundred and seven consecutive patients with nonvalvular chronic atrial fibrillation and 112 age and sex-matched control individuals with normal sinus rhythm were retrospectively included in the study from the outpatient cardiology clinic. Hematological variables, including MPV, platelet count, red blood cell and white blood cell count were measured in all patients and control individuals. Presence of coronary artery disease, hypertension, sex, hyperlipidemia, diabetes mellitus, smoking status, hematocrit and platelet count were comparable between two groups (P>0.05 for all). However, MPV and white blood cell count were significantly higher in patients with atrial fibrillation compared to those without atrial fibrillation. Logistic regression analysis revealed that white blood cell count and MPV significantly and independently associated with atrial fibrillation. We have shown that MPV and white blood cell count is independently associated with chronic nonvalvular atrial fibrillation. To improve the clinical utility of MPV and role of inflammation in the pathogenesis of atrial fibrillation, further studies are needed to be carried out. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.Öğe Response to Letter: Mean Platelet Volume in Patients With Dilated Cardiomyopathy and Left Ventricular Thrombus(Sage Publications Inc, 2012) Tekin, Gulacan; Tekin, Yusuf Kenan; Sivri, Nasir; Yetkin, Ertan[Abstract Not Available]Öğe Statins decrease mean platelet volume irrespective of cholesterol lowering effect(Via Medica, 2013) Sivri, Nasir; Tekin, Gulacan; Yalta, Kenan; Aksoy, Yuksel; Senen, Kubilay; Yetkin, ErtanBackground: Recent clinical observations have demonstrated that the beneficial effects of statins are not limited to LDL lowering effect. They have also favourable effects on platelet activation, endothelial function, inflammation, and coagulation cascade. Aim: To investigate the effects of statins on mean platelet volume (MPV) which is a simple measure of platelet activation volume in patients who have been prescribed statins. Atorvastatin and rosuvastatin were also compared in respect to effects on MPV. Methods: One hundred and forty five patients were retrospectively included in the study from the outpatient cardiology clinic. Patients who had been given statin treatment were recruited based on the records. Baseline and 4-8 weeks biochemical analysis and haematological measurements and cardiovascular risk factors were recorded. Results: Both statins significantly decreased the MPV. MPV of patients did not show any significant correlation with lipid parameters. Linear regression analysis revealed that there were no statistically significant associations of D MPV with the Delta LDL-cholesterol (beta coefficient = 0.13; p = 0.24), Delta HDL-cholesterol (beta coefficient = 0.17; p = 0.18) or Delta triglyceride (beta coefficient = -0.11; p = 0.21) after statin treatment. Both statins had comparable effects on lipid parameters at the end of the one month follow up period. Conclusion: Statins significantly reduce MPV irrespective of cholesterol levels, and atorvastatin and rosuvastatin have comparable effects in this regard.
