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Öğe Bilateral choroidal metastases as an initial manifestation of small-cell carcinoma of the lung(Turkish Assoc Tuberculosis & Thorax, 2006) Kocak, Zafer; Tabakoglu, Erhan; Benian, Omer; Bayir, Gulden; Unlu, Ercument; Uzal, CemThe occurence of clinically symptomatic intraocular metastases as an initial manifestation of primary neoplasm is rare event. The recognition of metastatic ocular tumors is important since they indicate a poor prognosis. Prompt diagnosis and treatment can significantly improve the quality of life for these patients. We report the case of a 48-year-old man presenting with a two-week history of left sided intraocular pain with blurring of vision and headache, which are the first signs of small-cell lung carcinoma.Öğe Bronchiolitis Obliterans Organizing Pneumonia: Three Cases Leading to Respiratory Failure(Bilimsel Tip Publishing House, 2005) Altiay, Gundeniz; Hatipoglu, Osman Nuri; Tabakoglu, Erhan; Yalcin, Omer; Caglar, TuncayBronchiolitis obliterans organizing pneumonia (BOOP) is an entity of unknown etiology characterized histologically by granulation tissue plugs within the lumens of small airways extending into the alveolar ducts and airways. The typical presenting symptoms and signs are dyspnea, cough, fever, weight loss, and a chest radiograph with single or multiple alveolar opacities. Some cases progress rapidly and have a poor prognosis. We followed-up three idiopathic BOOP cases in one month. Pathological diagnosis was based on transbronchial lung biopsy (TBLB) in all of them. The characteristic features of all cases were progressive respiratory failure. We treated them with high dose prednisolone for three days (first day 80 mg q6h, second day 80 mg q8h, third day 80 mg q12h) and continued with 1 mg/kg/d prednisolone. We observed rapid radiological and clinical improvement in all cases. Interestingly, these three patients were admitted to our clinic with progressive respiratory failure in the same one month period.Öğe A case of ruptured hydatid cyst with upper lobe localization that imitated active lung tuberculosis(Aves Yayincilik, Ibrahim Kara, 2007) Ozlen, Burcu; Ozdemir, Levent; Yoruk, Yener; Altiay, Gundeniz; Tabakoglu, Erhan; Hatipoglu, Osman NuriHydatid cyst is a parasitic infestation caused by Echinococcus granulosus. Although liver is the most common site of infection, lungs may also be affected in 10 to 30 % of cases. The cyst is usually located in the lower lobes. of the lungs. A 49-year-old male patient with a cavitary lesion in the posterior segment of the right upper lobe, was admitted to the tuberculosis ward with a preliminary diagnosis of lung tuberculosis (TB), and anti-TB treatment was started empirically. Bronchoscopy was performed after three different sputum examinations with negative results for acid-fast bacilli (AFB). Bronchoalveolar lavage examination was also negative for AFB. High resolution computed tomography showed findings of a ruptured hydatid cyst, rather than TB. A cysctotomy was performed to the patient whose indirect hemagglutination test result was negative for hydatid cyst.Öğe The Change of Antituberculosis Drug Resistance Rate in Edirne Region in 1996 and 2006(Wolters Kluwer Medknow Publications, 2010) Perincek, Gokhan; Tabakoglu, Erhan; Otkun, Metin; Ozdemir, LeventObjective: To establish the change in the ratio of the a ntituherculosis drug resistance in Edirne region between 1996-2006. Materials and Methods: The patients, who were detected with Mycobacterium tuberculosis proliferation in the cultures, were enrolled to the study between 1996-2006. The patients, who were diagnosed with isoniazid, rifampisin, ethambutol, streptomycin and multi-drug resistance were selected and their data of was uploaded to SPSS software in order to perform statistical analysis. Results: We found the Mycobacterium tuberculosis proliferation of cultures in 70 patients in 1996, whew. 21 patients had isoniazid, 8 patients had rifampicin, 7 patients had ethambutol, r patients had streptomycin, and 5 patients had multi Burg resistance. En 2006, illyrobacterium tuberculosis proliferation was established in 47 patients. Of these, 11 patients had isoniazid, 8 had rifampisin, one patient had ethambutol, 2 patients had streptomycin and 3 patients had multi-durg resistance. We compared the changes in the resistance figures and found a decrease: of drug resistance as follows: in isoniazid, from 21 patients (301Y0) to 11 patients (23.4%); in rifampisin, from 8 patients (11%) to 4 patients (8.5%0; in ethambutol, from 7 patients (13'Yo) to one patient (2.1`,0; in streptomycin, from r patients (39%) to 2 patients (4.3%); in multi drug, from 5 patients (7%) to 3 patients (6.4`%). Conclusion: Although statistically significant decrease of drug resistance was not found in isoniazid, rifampisin, ethambutol and multi-drug, a significant drug resistance \vas estabished in streptomycin in Edirne region during the 10 years period.Öğe Cisplatin-Dependent Nephrotoxicity in Patients with Lung Cancer(Kare Publ, 2016) Ozdemir, Burcu; Ozdemir, Levent; Hatipoglu, Osman; Tabakoglu, Erhan; Altiay, GundenizOBJECTIVE The aim of the present study was to investigate nephrotoxicity development ratios and clinical results of nephrotoxicity in patients diagnosed with lung cancer who received cisplatin in chemotherapy protocol. METHODS A total of 170 lung cancer patients were enrolled in the present prospective study. Renal functions were recorded for each patient before and after chemotherapy. Nephrotoxicity was defined as doubling in plasma creatinine concentration. Modification in treatment due to nephrotoxicity (reduction in cisplatin dosage, cisplatin interruption, or discontinuation of chemotherapy) was recorded during chemotherapy courses. RESULTS Decreasement of creatinine clearance levels was observed following each course of chemotherapy, but was especially noteworthy following the 1st and 5th courses (p=0.002; p=0.007, respectively). Nephrotoxicity was observed in 19 of the 170 patients (11%), in 10 of whom (53%) cisplatin dosage was reduced, and in 8 of whom (42%), cisplatin treatment was interrupted. Chemotherapy was discontinued in 1 patient (5%). CONCLUSION Particularly following the fourth course, chemotherapy must be carefully administered due to risk of nephrotoxicity.Öğe The Effect of Cisplatin plus Etoposide Therapy on Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Non-small Cell Lung Cancer(Turkish Biochem Soc, 2010) Gokmen, Selma Suer; Kazezoglu, Cemal; Tabakoglu, Erhan; Gungor, Ozgul; Altiay, Gundeniz; Ture, MevlutObjectives: To investigate the effect of cisplatin+etoposide therapy on serum total and lipid-bound sialic acid levels in patients with non-small cell lung cancer and evaluate the role of these parameters in the monitoring of the therapy. Patients and Methods: To 18 patients (all men) who are newly diagnosed as nonsmall cell lung cancer, cisplatin was given intravenously (80mg/m(2)) on day 1 and etoposide was given (100mg/m(2)) on day 1-3 to the patients once at an interval of 21 day. Blood samples before the first chemotherapy were compared with those obtained after the second and third chemotherapy. The percent of chemotherapy responses of patients were also calculated. Total and lipid-bound sialic levels were determined by the methods of Warren and Katopodis, respectively. Results: There was a significant decrease in serum lipid-bound sialic acid levels after the second chemotherapy when compared with those before the first chemotherapy (t=2.216, p=0.041). Positive response to cisplatin+etoposide therapy was observed in 88.89% (11.11% of total response, 44.44% of partial response and 33.33% of stable response) of the patients. Progressive disease was established in only 11.11% of the patients. It was found a statistically significant decrease in both serum total (t=2.924, p=0.017) and lipid-bound sialic acid (t=3.635, p=0.005) levels after the third chemotherapy when compared with those before the first chemotherapy. Conclusion: Determination of serum total and lipid-bound sialic acid levels besides routine applications may be useful in the monitoring of cisplatin+etoposide therapy.Öğe Effecting factors on survival in patients taking thrombolytic treatment due to massive pulmonary embolism(Turkish Assoc Tuberculosis & Thorax, 2010) Hatipoglu, Osman Nuri; Perincek, Gokhan; Edis, Ebru Cakir; Tabakoglu, Erhan; Altiay, GundenizMassive pulmonary embolism (MPE) is a life threatening disease, thrombolytic treatment could save lives. The aims of this study are to identify early and late mortality rates in patients with MPE who received thrombolytic treatment, and mortality related risk factors. All the hospital records for the MPE patients who received thrombolytic treatment between 1998 and 2006 were retrospectively investigated. Pulmonary embolism was diagnosed through computed tomografi scan and V/P scintigraphy. Due to MPE, 21 women total 41 patients who undergo tPA or streptokinase were included in the study. Kaplan-Meier for the survival analysis and cox regression analysis for determining the mortality related independent risk factors were used. Dying while staying in hospital was accepted as early or hospital mortality, after discharge from hospital as late mortality. Out of 41 patients, 12 of them died while they are hospitalized (hospital mortality; 29%) 6 of them died after they were discharged (late mortality; 21%). The average survival time among discharged patients was 2304 days (95% confidence interval: 1725-2884). Among those patients who took streptokinase or tPA, late or early mortality rates (p>0.05) and survival time did not show significant difference (p=0.8908). The presence of arrhythmia [p=0.01; odds rate (OR): 6.25] and jugular vein distention (JVD) (p=0.03; OR: 6.25) for hospital mortality and multiple ongoing health problems for the late mortality were identified as the independent risk factors. For the hospital mortality, the presence of JVD or arrhythmia, for prognostic sensitivity, specificity, positive predictive value and negative predictive value were recorded as 75%, 79%, 60% and 88% respectively. In conclusion, the presence of arrhythmia and/or JVD on a patient with MPE is a negative prognostic factor for hospital mortality. The presence of other ongoing health problems influences the survival time of the discharged patients.Öğe Effectiveness of Neuromuscular Electrical Stimulation on Auxiliary Respiratory Muscles in Patients with Chronic Obstructive Pulmonary Disease Treated in the Intensive Care Unit(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2015) Kurtoglu, Dilek Kocan; Tastekin, Nurettin; Birtane, Murat; Tabakoglu, Erhan; Sut, NecdetObjective: Chronic obstructive pulmonary disease is a major public health problem. In the present study, we aimed to investigate the possible effects of upper extremity exercises and neuromuscular electrical stimulation therapy applied to auxiliary respiratory muscles on arterial blood gases, blood pressure, heart rate values, and quality of life in patients with chronic obstructive pulmonary disease. Material and Methods: Thirty patients who were diagnosed with stage 4 severe chronic obstructive pulmonary disease by a pulmonologist and who needed intensive care were included in the study. The patients were equally allocated into two groups containing 15 patients each: control and intervention. Both groups were given an unassisted upper extremity exercise program for four weeks, and only one group was given neuromuscular electrical stimulation on auxiliary respiratory muscles for 10 days. Arterial blood gas measurements, peak heart rate, and breathing frequency were recorded. St. George's Respiratory Questionnaire and short form-36 were performed for the evaluation of the quality of life. Functional capacity was determined by functional independent measurement. Evaluations of the patients were performed on the 1st, 8th, 15th, and 30th days of the study. Results: There were statistically significant improvements in peak heart rate, breathing frequency per minute, and functional independency scores in the group where exercise and neuromuscular electrical stimulation had been concomitantly applied (p<0.05). Conclusion: This study revealed positive effects of neuromuscular electrical stimulation in addition with therapeutic exercises on the cardiorespiratory system in the short run.Öğe Fat Embolism: Case Report(Aves, 2006) Ozdemir, Levent; Tabakoglu, Erhan; Gurlu, Vuslat; Hatipoglu, Osman Nuri; Altiay, Gundeniz; Yilmam, Ilker; Ozlen, BurcuFat embolism syndrome is a rare disorder which usually may be seen as a complication of long bone trauma. It becomes apparent 24-72 hours after injury with respiratory, neurological, urinary, ocular and cutaneous symptoms and sings. Our case is a 46 years old male patient who evaluated 30 hours after left tibia fracture for confusion, fever, dyspnea, tachypnea and a petechial rash on the anterior chest and anterior axillary folds. Chest radiograph was normal. The patient had hypoxemia and hypocapnia in arterial blood gases measurement. Ventilation perfusion scintigraphy revealed emboli with intermediate probability. No other etiology could be found to explain the state of confusion. Cotton-wool exudates and small haemorrhages were observed in retina. Many fat globules were found in urine samples. After steroid treatment, rapid clinical improvement was observed.Öğe The importance of serum total and lipid-bound sialic acid as markers in patients with small cell and non-small cell lung carcinoma(Aves Yayincilik, Ibrahim Kara, 2007) Gokmen, Selma Suer; Kazezoglu, Cemal; Tabakoglu, Erhan; Altiay, Guendeniz; Gungoer, Ozgul; Ture, MevlutObjectives: Serum total sialic acid (TSA) and lipid-bound sialic acid (LSA) levels were investigated in patients with small and non-small cell lung carcinoma and their role in discriminating small from non-small cell lung carcinoma and lung carcinoma from healthy individuals was evaluated. Patients and Methods: The study included 159 male patients with non-small cell lung carcinoma (n=102) and small cell lung carcinoma (n=57) who never received chemotherapy and/or radiotherapy and 35 healthy volunteers as controls. Serum TSA and LSA levels were determined by the methods of Warren and Katopodis, respectively. Results: Serum TSA and LSA levels in both patient groups were significantly elevated when compared with controls (p < 0.001), but the patient groups did not differ significantly in this respect. Receiver operating characteristic (ROC) analysis showed that TSA was more specific and LSA was more sensitive in distinguishing patients with non-small cell carcinoma from healthy individuals. On the other hand, LSA was found to be more sensitive in distinguishing patients with small cell carcinoma from healthy controls. Conclusion: Serum total and lipid-bound sialic acid may play an important role as biochemical markers in distinguishing patients with small and non-small cell lung carcinoma from healthy subjects.Öğe The Influence of the Turkish Anti-Tobacco Law on Primary School Children in Edirne(Galenos Publ House, 2011) Tabakoglu, Erhan; Caglar, Tuncay; Hatipoglu, Osman N.; Altiay, Gundeniz; Edis, Ebru Cakir; Sut, NecdetObjective: The Turkish anti-tobacco law was accepted and effectuated in 1996. All forms of cigarette advertising, the sale of tobacco products to persons under the age of 18 and smoking in public institutions were all restricted. In this paper, we aimed to evaluate the influence of the Turkish anti-tobacco law on children for the periods before the law, after three years and after 10 years. Material and Methods: A self-completed questionnaire was distributed among primary school children. This included questions about the children's smoking habits, their opinions of parents' and teachers' smoking habits, tobacco use in public places and the recognition rate of 16 food, drink, cigarette and toothpaste logos and brand names, The first, second and third applications of the questionnaire were performed with students who attended the same classes in the same primary schools, accounting for 772 children in June 1996, 1,157 children in February 1999 and 719 children in June 2006. Results: When these three periods were evaluated, it could be seen that the prevalence of having smoked significantly decreased (13.9%, 4%, 2.2%, p<0.001), as did the rate of purchasing cigarettes within the past week (36.6%, 29.1%, 15.8%, p<0.001). The disagreement with parents' and teachers' smoking habits and tobacco usage in public places increased significantly (p<0.001), while the recognition rates of some cigarette brand names and logos significantly decreased, specifically with regards to Marlboro, Camel and Samsun (p<0.001). Conclusion: The Turkish anti-tobacco law has had a positive effect on primary school children in Edirne, and therefore could be a model for other countries.Öğe Massive Alveolar Hemorrhage During Wegener Granulomatosis: a Case Report(Galenos Publ House, 2011) Perincek, Gokhan; Tabakoglu, Erhan; Pamuk, Omer NuriThis is a presentation of Wegener Granulomatosis (WG) disease. Even though the lungs are rarely affected, massive alveolar hemorrhage is seen which leads to mortality. The patient was a 28 year old man. His illness was diagnosed as WG and glomerulonephritis a year previously and he was treated by administration of methylprednisolone orally. He had been treated irregularly. He applied to the emergency service with hemoptysis and asthma complaints two days earlier. After the results of his examination Hb: 3.6 gr/dl, Htc:10.3%, Ure:131 mg /dl, kreatini: 7.7 mg/di, pH: 7.41, pO2: 55 mmHg, pCO2:33 mmHg, and being diagnosed as alveolar consolidation on lung X-ray, he was taken to the intensive care unit with a diagnosis of a massive alveolar hemorrhagei. He was intubated and attached to mechanical ventilation. He was treated with parenteral 1 mg/kg/day methylprednisolone and, siklofosfamid 2 mg/kg/day. He was extubated on the 21(st) day. He was taken to the chest service department on 24(th) day. He is still being treated.Öğe Mortality Rates and Related Factors in Respiratory Intensive Care Unit Patients(Aves, 2007) Altiay, Gundeniz; Tabakoglu, Erhan; Ozdemir, Levent; Tokuc, Burcu; Cevirme, Leyla; Hatipoglu, Osman Nuri; Caglar, TuncayThe aim of this study is to identify the mortality rates and the influential factors in the respiratory intensive care unit (ICU). We prospectively evaluated a total of 150 patients consecutively admitted with respiratory failure between May 2003 and May 2005 in Trakya University Hospital, and 135 patients were enrolled in the study. The patients excluded from the study were the ones who died within the first 24 hours of ICU (n: 8), or had malignant diseases (n: 7). Chi-square test and t-test were used to compare hospital survivors with non-survivors, and logistic regression analysis was performed to define independent factors influencing the mortality rates in the hospital. To determine the efficiency of APACHE II, ROC analysis was used. 92 of the patients were male and 43 were female. The mean age was 64.9 +/- 12.9 years. The mortality rate was 32.6% (n: 44). The highest mortality rate was in patients with severe pneumonia/sepsis. (54.2%). The main conditions independently associated with increased mortality rate were arrhythmias (odds ratio [OR], 8.10; 95% confidence interval [CI], 2.67-24.58; p < 0.05), the need for invasive mechanical ventilation (OR, 6.04; 95% CI, 1.88 - 19.34; p < 0.05), the need for cardiotonic medication (OR: 5.36; % 95 CI: 1.67 - 17.22, p<0.05) and ventilator-associated pneumonia (OR: 5-21; 95% CI: 1.54-17.63; p < 0.05).Öğe A new clinical model in pulmonary embolism and its correlation with V/P scan results(Sage Publications Inc, 2006) Hatipoglu, Osman N.; Hanci, Emel; Tabakoglu, Erhan; Altiay, Gundeniz; Cermik, Tevfik Fikret; Caglar, TuncayThe study was prospectively designed to assess the correlation between a new clinical model empirically developed for acute pulmonary embolism (PE) and ventilation/perfusion (V/P) scan results. One hundred sixty consecutive patients with suspected acute PE underwent clinical evaluation before V/P scintigraphy. The clinical probability of PE was categorized according to a structured clinical model empirically developed as low, intermediate, or high, and the results were compared with those of V/P scintigraphy. Forty, 61, and 59 patients were classified as low, intermediate, and high clinical probability, respectively. Seventy-five percent (30/40) of the patients with low clinical probability were also of low scintigraphic probability or had a normal result (r(s): 0.39, p=0.000); 28% (17/61) of the patients with intermediate clinical probability demonstrated intermediate scintigraphic probability (r(s): 0.20, p=0.012); and 68% (40/59) of the patients with high clinical probability were also of high scintigraphic probability (r(s): 0.43, p=0.000). Overall, the correlation of two scoring systems was statistically significant (r(s): 0.39, p=0.000). Unilateral leg swelling (p=0.027), syncope or near syncope (p=0.002), amputation of a hilar artery (p=0.007), and electrocardiographic signs of right ventricular overload (p=0.000) prevailed in patients with high scintigraphic probability. Syncope-near syncope or hemodynamic collapse PLUS electrocardiographic signs of right ventricular overload or hypoxemia combination had the most significant correlation with a high scintigraphic probability (r(s): 0.31; p=0.000). In conclusion, the new clinical model empirically developed was significantly successful to provide comparable results with V/P scan. This consistency was particularly prominent in patients with low or high clinical probability for PE.Öğe Prevalence of asthma and allergic diseases in primary school children in Edirne, Turkey, two surveys 10 years apart(Wiley, 2010) Selcuk, Ziya Toros; Demir, Ahmet Ugur; Tabakoglu, Erhan; Caglar, TuncayTo assess change in prevalence and risk factors of asthma and allergic diseases among primary school children in rural and urban parts of Edirne, Turkey, a series of cross-sectional studies were conducted in 1994 and 2004. A questionnaire was administered to the parents of primary school children aged 7-12, in urban and rural parts of Edirne, Turkey (5412 in 1994 and 5735 in 2004). Response rates in 1994 and 2004 were 84% and 82.5%, respectively. There were significant differences between the age distribution, urban habitation (1994: 70.1%, 2004: 75.8%, p < 0.001), passive smoking (1994: 74.7%, 2004: 60.0%, p < 0.001), and family atopy (1994: 12.7%, 2004: 18.2%, p < 0.001) between the two surveys. Current prevalence of asthma and wheeze increased in the 2004 when compared to 1994 in both rural and urban regions (current asthma for rural and urban regions, 5.2% and 5.8% in 1994; 8.6% and 12.1% in 2004, respectively). Female-to-male ratio of current asthma increased from 0.7 in 1994 to 0.9 in 2004. Comparison of the risk factors in the two surveys suggested urban habitation and factors other than family atopy, passive smoking and no breast feeding as possible contributors for the increasing asthma and wheeze. Prevalence of asthma and allergic diseases increased among school children in Edirne, Turkey from 1994 to 2004. Life style changes and urbanization could be related to this increasing trend.Öğe Prognostic Factors Affecting Survival in Small Cell Lung Cancer Patients(Wolters Kluwer Medknow Publications, 2009) Ozlen, Burcu; Hatipoglu, Osman Nuri; Ozdemir, Levent; Sut, Necdet; Altiay, Gundeniz; Tabakoglu, ErhanAim: Small cell lung cancer (SCLC) is an aggressive tumour with a poor clinical course, but responsive to both chemotherapy and radiotherapy. Some clinical and laboratory parameters can predict survival in SCLC. The aim of this study was to analyze the survival and identify the prognostic factors that influence survival in SCLC. Material andMethod: Forty six consecutive SCLC patients who were planned for chemotherapy, enrolled in this study prospectively. We recorded basic characteristic properties and factors affecting prognosis for each patient. We determined their survival time and survival curves were calculated by the method of Kaplan and Meier analysis. Results: Median survival time was 338 days (95% confidence interval: 243-432). Survival ratio for one month was 89%, for 6 months 62% and for one year 45%. Significiant parameters (p< 0.05) evaluated by univariate analysis followed by multivariate analysis. In multivariate analysis liver metastas (Relative Risk (RR): 4.99, 95% confidence interval: 1,21 -20,53), weight loss (RR: 11.3, 95% confidence interval 1,11-115,5) and low level of total protein after first chemotherapy (RR: 0.198, 95% confidence interval 0,06-0,63) were found as independent factors affecting survival. Conclusion: SCLC is a disease with high mortality. Prognostic factors that we found, can be supported by further investigations.Öğe Resistance Rates of Antituberculosis Drugs in Pulmonary Tuberculosis Patients Producing Mycobacterium Tuberculosis(Aves, 2011) Perincek, Gokhan; Tabakoglu, Erhan; Otkun, Metin; Ozdemir, Levent; Ozdemir, BurcuObjective: Determination of antituberculosis drug resistance rate in pulmonary tuberculosis patients producing Mycobacterium tuberculosis. Material and Method: 134 pulmonary tuberculosis patients producing Mycobacterium tuberculosis in cultures in the Trakya University Medical Faculty Hospital between the years 2005-2007 were enrolled in the study. Four major antituberculosis drugs (H, R, streptomycin (SM), ethambutol (EMB)) resistance and multidrug resistance rates were investigated. using the BACTEC 460 TB system. Results: 134 pulmonary tuberculosis patients producing Mycobacterium tuberculosis were detected and 31 female patients were found and 103 male patients. Acid resistant bacilli were found in 58.2% of the patients with EZN. Antituberculosis resistance rates were established as H 10.4%, R 3%, EMB 0.7%, SM 0.7%. Conclusion: It was determined that a follow up of drug resistance patterns in patients with pulmonary tuberculosis will be useful in determining treatment protocols and preventing drug resistance.Öğe Skin prick test results in patients from Thrace region presenting with pulmonary symptoms(Aves Yayincilik, Ibrahim Kara, 2007) Edis, Ebru Cakir; Tabakoglu, Erhan; Caglar, Tuncay; Hatipoglu, Osman N.; Altiay, GuendenizObjectives: The aim of the study was to determine the profile of allergen sensitization in patients presenting with pulmonary symptoms. Patients and Methods: Skin test results of 196 patients (136 females, 60 males; mean age 34.7 +/- 11.7 years) presenting with pulmonary complaints between October 1999 and April 2005; total IgE results and allergy information forms were analyzed retrospectively. Results: Median value of IgE was (%25-75) 202 U/ml (118-530) in the patients enrolled. The most frequent symptom was shortness of breath (65.3%), and the second was cough (63.8%). These symptoms aggravated while patients were dusting. Sensitivity to at least one allergen was observed in 59.7% of the patients. Sensitivity to a single allergen was present in 18.9% and to multiple allergens in 40.8% of all patients. The most frequent allergy was determined to house dust mite (39.8%) and was followed by allergy to tree pollens (26%). Sensitivity rate to D. Farinea was 33.7% and 32.7% to D. Pteronyssinus. Conclusion: House dust mite were the primary causes of sensitization in patients presenting with allergic symptoms in the Thrace region. The fact that the symptoms aggravated in 46.9% of the patients while they were dusting at home, seemed to support this finding.Öğe Socioeconomic features and predisposing factors in patients with bronchiectasis(Aves Yayincilik, Ibrahim Kara, 2007) Ozdemir, Levent; Tabakoglu, Erhan; Hatipoglu, Osman Nuri; Altiay, Guendeniz; Ozlen, Burcu; Ciftci, Abdullah; Caglar, TuncayObjectives: The aim of this study was to determine socioeconomic features of cases with bronchiectasis and to determine predisposing factors which might play a role in the development of this condition. Patients and Methods: A total of 69 cases with bronchiectasis (43 males, 26 females; mean age 53.7 +/- 15.6 years) were retrospectively evaluated. Patients, totally in whom the was, predisposing factors for bronchiectasis, cigarette and alcohol consumptions, education and and monthly income levels were recorded. Results: Most of the cases multiple predisposing factors for bronchiectasis. Pneumonia (68%), measles (32%), and tuberculosis (18%) were the most common causes. Forty-two percent of the cases were primary school graduates and 20% never attended school. Fifty-five percent of the cases smoked cigarettes and 19% of the cases used alcohol. The mean monthly income was found to be 438.2 +/- 363 YTL. Conclusion: We concluded that bronchiectasis is prominent among individuals with low socioeconomic level.Öğe Treatment of a primary pulmonary alveolar proteinosis case with severe hypoxaemia by using segmental lavage technique(Acad Medicine Singapore, 2007) Edis, Ebru Cakir; Tabakoglu, Erhan; Caglar, Tuncay; Hatipoglu, Osman Nuri; Cevirme, Leyla; Alagol, Aysin[Abstract Not Available]