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    Synthesis, spectral analysis, antimicrobial, cytotoxicity, and antioxidant studies of gold(III) complex of caffeine
    (Taylor & Francis Ltd, 2019) Altun, Ozlen; Suozer, Mehtap
    In the present study, the reactions involving caffeine (CA) and gold(III) were investigated. The synthesized complex was characterized by using mass, UV-visible, FTIR, H-1 and C-13 NMR, and TG-DTA analyses. From these analyses, it is predicted that the complex has the formula [Au(CA)(2)(Cl)(2)]Cl. In addition, antimicrobial, cytotoxicity, and antioxidant activities of the obtained complex were investigated. Investigation of antimicrobial properties demonstrated that the complex has important antibacterial and antifungal activities. The cytotoxic activity of the complex showed potent cytotoxicity against growth of human prostate (Du145), cervix (HeLa), colon (HT29), and breast (MCF7) cancer cells. Additionally, the complex showed significant antioxidant activity.
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    Synthesis, spectral analysis, stability constants, antioxidant and biological activities of Co (II), Ni (II) and Cu (II) mixed ligand complexes of nicotinamide, theophylline and thiocyanate
    (Elsevier Science Bv, 2017) Altun, Ozlen; Suozer, Mehtap
    In the present study, transition metal complexes or coordination entities with metal precursors such as Co (II), Ni (II) and Cu (II) of mixed ligands namely, nicotinamide (NA), theophylline (TP) and KSCN in water were synthesized under refiuxing conditions. The optimization of the reactions to obtain the composition of complexes was performed. The structural elucidation of the complexes was undertaken by using physico-chemical and spectroscopic methods (UV/Vis, FT-IR, Mass and XRD) and thermal analysis. The spectral measurements of mixed ligands with the Co (II), Ni (II) and Cu (II) complexes are compared with each other in determining which atoms of the ligand are coordinated to the metal ion. Based on spectral and magnetic moment measurements, all the coordination entities were identified as in distorted octahedral structure and have the form [M(NA)(2)(TP)(2)(SCN)(2)].xH(2)O. In addition, K (stability constant) and AG (Gibbs free energy) values were calculated by using the Babko and Stanley & Turner's methods. Antioxidant, antibacterial and antifungal activities of the complexes were studied. (C) 2017 Elsevier B.V. All rights reserved.