DSpace Arşivi :: by Yazar "Sonmez, Mehmet Bulent" değerine göre listeleniyor

Yazar "Sonmez, Mehmet Bulent" seçeneğine göre listele

Listeleniyor 1 - 20 / 20

Acute sleep deprivation immediately increases serum GDNF, BDNF and VEGF levels in healthy subjects
(Springer Japan Kk, 2022) Gorgulu, Yasemin; Caliyurt, Okan; Cinar, Rugul Kose; Sonmez, Mehmet Bulent
Acute sleep deprivation upregulates hippocampal neurogenesis. Neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) are mediators of neuronal plasticity and neurogenesis. These neurotrophins are involved in sleep and sleep disorders and are associated with sleep deprivation. In this study, it is aimed to investigate the changes of neurotrophin levels with total sleep deprivation in healthy individuals. Seventeen healthy young adults with a mean age of 19.8 (SD = 1.0) years underwent an experimental protocol consisting of 36 h of total sleep deprivation. Venous blood samples were obtained on Day1 at 09.00, on Day2 at 09.00, and at 21.00. Serum levels of neurotrophins were detected using the ELISA method. The participants were asked to mark the scores corresponding to their subjective energy, happiness, depression, tension levels on the visual analog scale; and sleepiness level on the Epworth Sleepiness Scale; during the course of the study. As a result of 36 h of sleep deprivation, serum GDNF, BDNF, and VEGF levels showed a statistically significant increase compared to the baseline values in the participants included in the study (P < 0.0001). While this increase was evident in 24 h, it continued after 36 h. In parallel, sleepiness levels, subjective depression, and tension levels increased, on the other hand, subjective energy and happiness scores decreased at a statistically significant level at the end of the study compared to basal values (P < 0.0001). The results show that acute sleep deprivation significantly affects and increases serum levels of neurotrophic factors, and it seems that these effects are likely to occur as an immediate response to the stress and disruption caused by sleep deprivation.
Alcohol and Psychoactive Substance Use among University Students in Edirne and Related Parameters
(Aves, 2016) Gorgulu, Yasemin; Cakir, Digdem; Sonmez, Mehmet Bulent; Kose Cinar, Rugul; Vardar, Mehmet Erdal
Introduction: Alcohol and psychoactive substance use and their effects are an important issue among adolescents and young adults. Different results have been reported about the frequency of alcohol and psychoactive substance use among university students in studies conducted both in Turkey and in different places worldwide. Methods: The frequency of alcohol and psychoactive substance use among Trakya University students (n=1385) and the related parameters were studied cross-sectionally using a self-reporting questionnaire. Results: Alcohol was the most common substance used (30%), followed by tobacco (29.9%) and marijuana (3.1%). The frequency of alcohol and psychoactive substance use was found to be higher among males with higher amounts of pocket money, whose parents experienced more conflict in their relationship, and who belong to families with a higher education and income level. Conclusion: The frequency of alcohol and psychoactive substance use among Trakya University students was found to be lower than other regions in Turkey and particularly lower than the levels reported in studies conducted in other countries.
Alterations of BDNF and GDNF serum levels in alcohol-addicted patients during alcohol withdrawal
(European Journal Of Psychiatry, 2016) Sonmez, Mehmet Bulent; Gorgulu, Yasemin; Cinar, Rugul Kose; Kilic, Evnur Kahyaci; Unal, Aycan; Vardar, Mehmet Erdal
Background and Objectives: Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are neurotrophic neuropeptides that play important roles in the synaptic plasticity, neuronal growth, survival and function. A possible neuroprotective role of neurotrophic factors against alcohol-induced cell damage has been suggested, and dysregulations in neurotrophic factors may be involved in the vulnerability to addiction. The aim of this study was to investigate the alterations of BDNF and GDNF serum levels in alcohol-addicted patients during alcohol withdrawal compared to healthy controls. Methods: BDNF and GDNF serum levels of 34 male inpatients diagnosed with alcohol addiction according to DSM-IV-TR were investigated during alcohol withdrawal (day 1, 7 and 14) in comparison to 32 healthy controls using an enzyme-linked immunosorbent assay (ELISA). Severity of alcohol withdrawal was measured by Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar), and intensity of alcohol craving was measured by Penn Alcohol Craving Scale (PACS) during alcohol withdrawal (day 1, 7 and 14). Results: BDNF serum levels increased significantly during alcohol withdrawal (p = 0.020). They were negatively correlated to the severity of alcohol withdrawal, and the correlation was close to being statistically significant (p = 0.058). BDNF and GDNF serum levels did not differ significantly between the patient and control groups. GDNF serum levels did not change significantly during alcohol withdrawal. Conclusions: Our results may provide support for the previously hypothesized role of BDNF in the neuroadaptation during alcohol withdrawal.
The association of temperament with nausea and vomiting during early pregnancy
(Taylor & Francis Inc, 2019) Bahadirli, Ali; Sonmez, Mehmet Bulent; Memis, Cagdas Oyku; Bahadirli, Nil Banu; Memis, Seda Derici; Dogan, Bilge; Sevincok, Levent
We aimed to investigate the relationship between affective temperaments and the severity of nausea and vomiting symptoms in early pregnancy (NVP). The pregnant women who did (n = 187) or did not report (n = 71) any nausea and vomiting at three consecutive assessments with the Pregnancy-Unique Quantification of Emesis Scoring Index (PUQE) (n = 71) were examined. Affective temperamental traits were assessed by Temperament Evaluation of Memphis, Pisa, Paris and San Diego auto-questionnaire (TEMPS-A). The anxious (p < .0001), depressive (p = .003), cyclothymic (p = .03) and irritable (p = .021) temperament traits in NVP patients were significantly higher than in controls. There were significant correlations between the PUQE scores and depressive (p = .002), cyclothymic (p = .001), irritable (p = .001) and anxious (p = .001) traits. Anxious temparement (p = .004) and being a housewife (p = .012) were significantly associated with NVP. Our results suggest that women with a predominantly anxious temperament are more vulnerable to developing somatic complaints such as nausea and vomiting during pregnancy.
Associations between energy drink consumption and alcohol use among college students
(Taylor & Francis Inc, 2018) Bahadirli, Nil Banu; Sonmez, Mehmet Bulent; Vardar, Mehmet Erdal
Introduction: The aims of our study are to research the general features of energy drink consumption among college students, the association between energy drink consumption and alcohol use while controlling for demographic attributes and general risk taking propensity. Methods: The study was carried out using data collected from 2,632 college students at Trakya University (Edirne, Turkey). The study data were obtained from the Alcohol Use Disorders Identification Test, Addiction Profile Index, Energy Drink Consumption Data Form, Barratt Impulsiveness Scale, and Zuckerman Sensation Seeking Scale. Results: Of all the students, 59.9% had used energy drinks within the last year and 26.4% had used energy drinks within the last 1 month. Of the subjects who used energy drinks within the last month, 26.1% had high consumption frequency (>= 6 days/month). Energy drink consumption within the last year and last month predicted alcohol use within the last year and last month, binge drinking, and hazardous/harmful alcohol use in the logistic regression analysis. In addition, the high energy drink consumption frequency predicted hazardous/harmful alcohol use. Discussion: The association between energy drink consumption and alcohol use, independent from other variables related to alcohol use, highlights the importance of raising awareness among college students.
A Case of Acute Psychosis Following Energy Drink Consumption
(Galenos Yayincilik, 2014) Goruglu, Yasemin; Tasdelen, Oznur; Sonmez, Mehmet Bulent; Kose Cinar, Rugul
Interest in energy drinks is increasing every day. Energy drink consumption is increasing proportionally. Users often utilize these drinks in order to enjoy, have fun and to increase performance and attention. However, consumption of the energy drinks sometimes may also cause adverse physical and psychological consequences. Unwanted physical results are in the more foreground, noticeable and visible but the data about psychological problems caused by energy drinks is accumulated over the years in the literature. In this case report, we describe the case of a young man with no psychiatric history who was hospitalized for psychotic symptoms following excessive consumption of energy drinks.
Decision-making, interoceptive awareness and mindful attention awareness in male patients with alcohol use disorder
(Routledge Journals, Taylor & Francis Ltd, 2022) Avcu Meric, Isil; Sonmez, Mehmet Bulent
Introduction: Decision-making deficits in individuals with alcohol use disorder (AUD) may be partly related to their decreased interoceptive awareness (IA), which is associated with some aspects of mindfulness. Methods: 52 abstinent male inpatients with AUD (current severity: moderate or severe) and 52 healthy male volunteers performed the heart rate tracking task and a computerised version of the Iowa gambling task (IGT). Trait mindfulness was evaluated with the mindful attention awareness scale (MAAS). Results: Heartbeat perception (HBP), MAAS, and IGT scores of patients with AUD were significantly lower than those of healthy controls. The difference between groups with respect to IGT scores did not remain significant after controlling for the covariates, and HBP scores were linked significantly to the subjects' IGT performance. HBP scores significantly predicted IGT scores of both the overall sample and patients. MAAS scores did not correlate significantly with HBP and IGT scores in either the patient or control group. Conclusion: It is possible that IA plays a role in decision-making and decreased interoceptive accuracy is a predictor of impaired decision-making in individuals with AUD. More empirical data are needed to develop a better insight into the relationship between IA and multi-dimensional nature of mindfulness.
Decreased interoceptive awareness in patients with substance use disorders
(Taylor & Francis Inc, 2017) Sonmez, Mehmet Bulent; Kilic, Evnur Kahyaci; Col, Isil Ates; Gorgulu, Yasemin; Cinar, Rugul Kose
Introduction: The current study was prepared based on the assumption that awareness of the interoceptive processes may be disturbed in addicted individuals, Methods: The participants in the study included 84 abstinent male inpatients who were addicted to alcohol (n = 33), heroin (n = 29), or synthetic cannabinoids (n = 22) according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR), and 35 healthy male volunteers. Interoceptive awareness (IA) was measured using the heartbeat perception (HBP) task. Addiction severity was assessed using the addiction profile index (API). Alexithymia was assessed using the Toronto alexithymia scale (TAS-20). Results: Patients addicted to alcohol, heroin, or synthetic cannabinoids had similar IA, and their HBP scores were significantly lower than those of healthy control subjects. There was a significant negative correlation between HBP scores and TAS-20 subscores, thus indicating difficulties in identifying feelings. HBP scores were not significantly correlated with API scores. API scores were significantly correlated with total alexithymia scores and subscores, thus indicating difficulties in identifying and describing feelings. Discussion: As our main finding, a decrease in IA in addicted patients in comparison to healthy controls may provide support for the hypothesis that awareness of the interoceptive processes may be disturbed in addiction.
Evaluation of Interoceptive Awareness in Alcohol-Addicted Patients
(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2016) Ates Col, Isil; Sonmez, Mehmet Bulent; Vardar, Mehmet Erdal
Introduction: Interoceptive awareness (IA) is defined as an ability to accurately perceive interoceptive processes, which comprise receiving, processing, and integrating body-relevant signals together with external stimuli. Interoceptive processes affect the motivated approach or avoidance behavior toward stimuli. Alcohol and other substances have effects on the autonomic system that result in altered interoceptive processes. Individuals who have disturbed IA may be at a higher risk of addiction because they are not able to utilize sufficiently body-relevant signals to guide their decision-making. The hypothesis that IA in alcohol-addicted patients would be affected and that the disturbed IA would be associated with alcohol craving was tested in this study. Methods: The study was conducted with 55 patients diagnosed with alcohol addiction according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria and who had been sober for at least two weeks and 52 non-addicted healthy controls. IA measurements were performed using the heartbeat perception performance method, which determines participants' awareness of their own heartbeat by comparing the number of subjectively perceived heartbeats with an objective heart rate measure recorded with ECG during four separate intervals. In addition, the Alcohol Use Disorders Identification Test (AUDIT), Penn Alcohol Craving Scale (PACS), and Obsessive Compulsive Drinking Scale (OCDS) were performed on the alcohol-addicted patient group. Results: IA scores were significantly lower in the alcohol-addicted patients than the control subjects. IA scores of alcohol-addicted patients were negatively correlated with the levels of alcohol craving sensations according to the PACS results. Conclusion: Our results corroborate the suggestion that IA in alcohol-addicted patients would be affected and that poor IA would be associated with alcohol craving and could be a maintaining factor for drinking behavior.
Evaluation of phosphatidylethanol by ELISA for detection of excessive alcohol use compared with traditional biomarkers: a case-control study
(Taylor & Francis Ltd, 2017) Sonmez, Mehmet Bulent; Cinar, Rugul Kose; Gorgulu, Yasemin; Kilic, Evnur Kahyaci; Unal, Aycan
Objective: The highly sensitive chromatographic methods for quantifying phosphatidylethanol (PEth) require high levels of expertice and expensive instrumentation. Enzyme-linked immunosorbent assay (ELISA) kits have been developed for research purposes, but the implementation of PEth immunoassays to screen alcohol consumption has not been applied to the analysis of clinical samples. Our aim was to examine the ELISA method for PEth analysis in clinical samples. Methods: We examined the alterations of the PEth serum levels of 22 male inpatients diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, during alcohol withdrawal (at days 1, 7, and 14) compared to 32 healthy controls using ELISA. All patients were admitted for detoxification treatment at the Alcohol and Substance Addiction Treatment and Rehabilitation Center, Trakya University School of Medicine, Edirne, Turkey. Control subjects were assessed with an initial clinical interview and screened with the Alcohol Use Disorder Identification Test (AUDIT), and they included 16 nondrinkers (AUDIT score = 0) and 16 social drinkers (AUDIT score < 8). We examined the diagnostic accuracy of PEth compared to the traditional biomarkers according to the receiver operating characteristic curve analysis. Results: The patients undergoing detoxification had higher baseline PEth levels than the nondrinkers and social drinkers; the difference between groups showed a marginal trend towards significance (p = 0.052). PEth was correlated with the self-reported drinking amount in the past month and AUDIT scores, and the correlations showed marginal trends towards significance (r(s) = 0.269, p = 0.049; and rs = 0.266, p = 0.052; respectively). The PEth levels were statistically significantly correlated with gamma-glutamyl transferase (GGT) (r(s) = 0.355, p = 0.010), the correlations with alanine aminotransferase (ALT) and aspartate aminotransferase (AST) trended towards statistical significance (r(s) = 0.230, p = 0.095; and r(s) = 0.261, p = 0.056, respectively), and PEth was not statistically significantly correlated with mean corpuscular volume (MCV) (r(s) = 0.100, p = 0.478). PEth levels decreased statistically significantly during alcohol withdrawal (p = 0.002). PEth levels of the nondrinkers and social drinkers did not differ statistically significantly (p = 1.000). The area under the curve (AUC) for PEth measured by ELISA was statistically significantly higher than 0.5 (AUC = 0.691, p = 0.024), but PEth had poorer diagnostic efficacy than GGT (AUC = 0.933, p < 0.001), AST (AUC = 0.931, p < 0.001), MCV (AUC = 0.803, p < 0.001), and ALT (AUC = 0.789, p < 0.01). Conclusions: The AUC of 0.69 shows that the diagnostic accuracy of the assay was poor, regardless of a statistical comparison to 0.5. The use of serum might have led to low concentrations that have not differed much between heavy drinkers and social drinkers or abstainers. Whole blood ELISA implementation for the quantification of PEth may increase its diagnostic efficacy.
Evaluation of the levels of leptin, ghrelin, and prolactin in alcohol dependent patients
(Kure Iletisim Grubu A S, 2011) Zeren, Ugur; Sonmez, Mehmet Bulent; Vardar, Erdal
Objective: Alcohol dependence doesn't develop in all individuals consuming alcohol; therefore risk factors for dependence, its etiology, and the bases of the urge to drink alcohol should be investigated. As hormones have different functions in the body, they have been among the subjects of research to determine these factors. Especially the hormones affecting food intake could be thought to have a relationship with alcohol consumption. The aim of this study was to investigate whether the hormones affecting food intake play a role in alcohol dependence. Method: Twenty-one patients were included in the study. All patients were referred to and hospitalized in the Department of Psychiatry, Trakya University School of Medicine. They were clinically evaluated and diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) criteria. Fasting blood samples were collected at 08:00 AM on the first day of hospitalization, which was also the day the patients gave up drinking (day 0), and then on the following 1(st), 7(th), and 28(th) days to measure ghrelin, leptin, and prolactin levels. Twenty one healthy volunteers (20 males, 1 female), who had not consumed any alcohol for at least ten days and did not meet the criteria for alcohol dependence based on the DSM-IV, were included in this study. Blood samples were collected from the control group for determination of levels of ghrelin, leptin, and prolactin. Results: There were no significant differences between the alcohol dependent patient group and the healthy control group regarding leptin, ghrelin or prolactin levels. Additionally, there were no significant differences between the leptin and prolactin levels on day 0, 1, 7, and 28 in the patient group. A statistically significant decrease was found in ghrelin levels of alcohol dependent patients between the days of 0 and 28 and between the days of 1 and 28. Conclusions: Because of the decline in the ghrelin levels on day 28 compared to day 0 and 1, there is a need for further studies on alcohol dependent patients. The evaluation of more prolonged sobriety days may also be useful. This study did not support the hypothesis that leptin, ghrelin, and prolactin levels are a biological indicator for alcohol dependence.
Impact of Experiencing Acute Coronary Syndrome Prior to Open Heart Surgery on Psychiatric Status
(Soc Brasil Cirurgia Cardiovasc, 2016) Yuksel, Volkan; Gorgulu, Yasemin; Cinar, Rugul Kose; Huseyin, Serhat; Sonmez, Mehmet Bulent; Canbaz, Suat
Objective: The incidence of depression and anxiety is higher in patients with acute coronary syndrome. The aim of this study is to determine whether experiencing acute coronary syndrome prior to open heart surgery affects patients in terms of depression, hopelessness, anxiety, fear of death and quality of life. Methods: The study included 63 patients who underwent coronary bypass surgery between January 2015 and January 2016. The patients were divided into two groups: those diagnosed after acute coronary syndrome (Group 1) and those diagnosed without acute coronary syndrome (Group 2). Beck depression scale, Beck hopelessness scale, Templer death anxiety scale and death depression scale, State-Trait anxiety inventory and WHOQOL-Bref quality of life scale were applied. Results: There was no significant difference between the two groups in terms of the total score obtained from Beck depression scale, Beck hopelessness scale - future-related emotions, loss of motivation, future-related expectations subgroups, death anxiety scale, the death depression scale, State-Trait Anxiety Inventory social and environmental subgroups. The mental quality of life sub-scores of group 2 were significantly higher. The patients in both groups were found to be depressed and hopeless about the future. Anxiety levels were found to be significantly higher in all of the patients in both groups. Conclusion: Acute coronary syndrome before coronary artery bypass surgery impairs more the quality of life in mental terms. But unexpectedly there are no differences in terms of depression, hopelessness, anxiety and fear of death.
Interoceptive Awareness, Decision-Making and Impulsiveness in Male Patients with Alcohol or Opioid Use Disorder
(Taylor & Francis Inc, 2021) Subay, Busra; Sonmez, Mehmet Bulent
Background The present study was prepared on the assumption that interoceptive awareness (IA) and decision-making processes are implicated in addiction, and that somatic feedback plays an important role in decision-making. Methods The study participants included 80 abstinent male inpatients with alcohol use disorder (n = 40) or opioid use disorder (n = 40) according to DSM-5 criteria (current severity: moderate or severe), along with 40 healthy male volunteers. All participants performed the heart rate tracking task as an objective physiological performance measure of IA and a computerized version of the Iowa gambling task (IGT) as a validated measure of decision-making. Impulsiveness was assessed using the Barratt Impulsiveness Scale 11 (BIS-11). Craving was evaluated with the Penn Alcohol Craving Scale (PACS) or Substance Craving Scale (SCS). Results (1) Heartbeat perception (HBP) and IGT scores were similar between the patients with alcohol or opioid addiction, being significantly lower than those in the control group, and the difference remained significant even when controlling for the factors that were significant in bivariate analyses; (2) HBP scores of patients correlated significantly with IGT scores, even when controlling the effect of the related variables; (3) BIS-11 scores of patients negatively correlated significantly with HBP scores and did not correlate significantly with IGT scores; and (4) PACS/SCS scores did not correlate significantly with HBP and IGT scores. Conclusions Our findings support the hypothesis that IA and decision-making processes are implicated in addiction and that decreased IA is associated with impaired decision-making.
Late-onset clozapine-induced neutropenia treated with lithium
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2019) Durmus, Pelin Tas; Gorgulu, Yasemin; Sonmez, Mehmet Bulent; Cinar, Rugul Kose
Clozapine is a second-generation antipsychotic drug, proven to be effective in treatment-resistant schizophrenia. Among patients using clozapine; the incidence of neutropenia is approximately 3% and the incidence of agranulocytosis is approximately 1%. This side effect is diminishing after 18 weeks of drug initiation. Here, we present a case of clozapine-induced neutropenia in a schizophrenic patient seen after 7 years of clozapine use and its treatment with lithium supplementation.
Peripheral blood mRNA expressions of stress biomarkers in manic episode and subsequent remission
(Pergamon-Elsevier Science Ltd, 2016) Cinar, Rugul Kose; Sonmez, Mehmet Bulent; Gorgulu, Yasemin
Theoretical models of the neuroprogressive nature of bipolar disorder (BD) are based on the hypothesis that it is an accelerated aging disease, with the allostatic load playing a major role. Glucocorticoids, oxidative stress markers, inflammatory cytokines and neurotrophins play important roles in BD. The messenger ribonucleic acid (mRNA) expressions of brain-derived neurotrophic factor (BDNF), tissue plasminogen activator (tPA), glucocorticoid receptor (GR), heat shock protein 70 (HSP70), tumour necrosis factor alpha (TNF-alpha) were examined in the peripheral blood of 20 adult male, drug-free BD patients during manic and remission periods and in 20 adult male, healthy controls. mRNA expression was measured using the quantitative real-time polymerase chain reaction (qRT-PCR). Compared to the controls, the expressions of BDNF and tPA mRNA were down-regulated in mania. In remission, BNDF and tPA mRNA levels increased, but they were still lower than those of the controls. Between mania and remission periods, only the change in mRNA levels of BDNF reached statistical significance. The results suggest that BDNF and tPA may be biomarkers of BD and that proteolytic conversion of BDNF may be important in the pathophysiology of BD. The change in BDNF levels between mania and remission could be adaptive and used to follow the progression of BD. (C) 2016 Elsevier Ltd. All rights reserved.
Pregabalin Use Disorder
(Aves, 2015) Sonmez, Mehmet Bulent
[Abstract Not Available]
Psychotic depression after obesity surgery and recovery with vitamin B12 replacement
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2019) Sozer, Kubra; Gorgulu, Yasemin; Sonmez, Mehmet Bulent; Cinar, Rugul Kose
While obesity surgery can improve obesity and its complications, it may decrease the absorption of some foods in the stomach. It is known that from the first day after gastric bypass operation, the blood level of B12 start to decrease. However, the change of B12 levels can be measurable after 6 months. B12 deficiency may cause several psychiatric and neurological disorders or aggravate psychiatric symptoms. In this case report, we present a patient who had been in remission before gastric surgery but developed major depression with psychotic features and to describe the course of treatment.
Relationship of Interoceptive Accuracy With Risky Decision-Making and Treatment Outcomes in Male Patients With Alcohol Use Disorder
(Hogrefe Publishing Corp, 2022) Sonmez, Mehmet Bulent; Meric, Isil Avcu; Subay, Busra; Gorgulu, Yasemin
Lower levels of interoceptive awareness (IA) may be present in individuals with substance use disorder (SUD), and damage to related brain regions caused by substance use may disrupt IA. Disturbance in the bodily feedback system may fail to engage in effective decision-making. This study focused on the premise that interoceptive accuracy (IAc), as the primary construct of IA, is implicated in SUD and that poor IAc is linked to risky decision-making and adversely affects treatment outcomes. Eighty-five patients with alcohol use disorder (AUD) (current severity: moderate or severe) and 87 healthy control subjects were enrolled in the present study. All participants performed the heart rate tracking task and a computerized version of the Iowa gambling task (IGT). Characteristics of patients' addiction profiles were assessed with the Addiction Profile Index (API) Clinical Form. IAc and IGT scores of patients with AUD were tower than healthy controls. IGT scores of patients with low IAc were lower than those of patients with high IAc and decreased IAc is predictive of decreased IGT scores. No significant differences were determined in treatment outcomes at 3, 6, and 12 months after hospitalization between the low-IAc and high-IAc patient groups. Our results suggest that lAc is implicated in AUD and that poor IAc is predictive of increased risky decision-making. Risky decision-making that results in substance use may be partly related to a deficit in the interoceptive ability to guide behavior. Focus on IAc without reference to complex clinical case presentations in AUD makes it difficult to draw any definitive conclusions about the rote of IAc in clinical outcomes.
Serum agouti-related protein (AgRP) levels in bipolar disorder: Could AgRP be a state marker for mania?
(Elsevier Ireland Ltd, 2018) Parlak, Naci; Gorgulu, Yasemin; Cinar, Rugul Kose; Sonmez, Mehmet Bulent; Parlak, Ebru
Orexigenic and anorexigenic peptides, especially agouti-related protein (AgRP) and leptin, play important roles in the regulation of energy homeostasis in bipolar disorder. AgRP regulates energy metabolism by increasing appetite and decreasing energy expenditure. The resting energy expenditures of patients with manic bipolar disorder are higher than those of controls. Due to the effects of AgRP on energy expenditure and the increased physical activity of manic patients, we hypothesised that serum AgRP levels may be lower in manic patients than in euthymic patients and controls. There was a total of 112 participants, including 47 patients in the manic group, 35 patients in the euthymic group and 30 healthy controls. For this study, serum AgRP, leptin, cholesterol, and cortisol levels were measured and compared between the groups. The serum AgRP, leptin, and cholesterol levels were significantly different between the groups. The serum AgRP levels of manic group were significantly lower than those of euthymic and control groups. The lower serum AgRP levels of manic patients could be indicators of impaired energy homeostasis during manic episodes. Since the serum AgRP levels of manic patients are lower than those of euthymic patients and controls, AgRP could be a state marker for manic episodes.
Substance Use and Parent Characteristics Among High School Students: Edirne Sample in Turkey
(Routledge Journals, Taylor & Francis Ltd, 2016) Sonmez, Mehmet Bulent; Cakir, Digdem; Cinar, Rugul Kose; Gorgulu, Yasemin; Vardar, Erdal
The current study on substance use and family characteristics of adolescents is a part of the extensive research on substance use characteristics among high school students in Edirne, Turkey. This cross-sectional study was conducted with 8,483 high school students within the 2010-2011 academic year. Self-administered questionnaires were completed anonymously by the participants. The lifetime prevalence of alcohol use was 24.6% and tobacco use was 21.4%. The most commonly used illicit substance was cannabis (1%), followed by inhalants (0.5%) and ecstasy (0.4%). The use of alcohol, tobacco, and nearly all the illegal substances was significantly higher among males compared to females. The rates of lifetime substance use varied by family-related factors such as family structure, perceived parental attitudes and intrafamilial relationships, parental socioeconomic status, and parental substance use. The limitations and implications of these findings are discussed.

Yazar "Sonmez, Mehmet Bulent" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri