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Öğe Acute Effects of Intermittent Exercise Performed at Anaerobic Threshold Level on Vascular Function in Healthy Young Men(Wiley, 2019) Sen, Burcu; Solak, Serdar; Tayfur, Pinar; Aydogdu, Nurettin; Sut, Necdet; Vardar, Selma Arzu[Abstract Not Available]Öğe Anatomical variations of the circle of Willis in children(Springer, 2021) Solak, Serdar; Ustabasioglu, Fethi Emre; Alkan, Aykut; Kula, Osman; Sut, Necdet; Tuncbilek, NerminBackground The morphology of the circle of Willis in adults has been thoroughly discussed in scientific literature. However, the morphology of the circle of Willis in pediatric patients is under-researched. Objectives We aimed to establish reference data for the morphology and variations of the circle of Willis in a population consisting of all pediatric age subgroups and to evaluate the possible temporal evolution of the circle of Willis in pediatric patients along with the variations between pediatric and adult populations. Materials and methods Our patient cohort included 263 pediatric patients ages 1-215 months. A total of 273 magnetic resonance (MR) angiography images were retrospectively analyzed for all circle of Willis vessels to compare the incidence of complete cases and variation frequency based on gender and age group. Result In our study of 273 MR angiograms from all age ranges in the pediatric population, we found a 56.1% circle of Willis completion rate. Overall completion rates were statistically significantly higher in the toddler and preschool age groups. The lowest completion rate was in the newborn-infant group (40%). Conclusion Circle of Willis completion rates and variations in pediatric populations are similar to those in adult populations; completion rates rise in toddler and preschooler age groups and decline as children grow into the school-age and adolescent period.Öğe The comparison of endothelial function of moderate intensity interval exercise with continuous exercise in healthy men(Elsevier, 2022) Meric, Burcu; Solak, Serdar; Aydogdu, Nurettin; Sut, Necdet; Vardar, Selma ArzuBackground/aim: Exercise enhances endothelium-dependent vasodilation; however, it is unclear whether intermittent exercise has a different effect on vascular endothelial function compared to continuous exercise. This study aimed to compare vascular endothelial function following intermittent exercise including short rest intervals with continuous exercise, both at the anaerobic threshold level. Materials and methods: Peak oxygen consumption (VO2 peak) and anaerobic threshold were measured in physically active healthy young men (n = 12) by breath-by-breath analysis. After completion of intermittent exercise consisting of eight 1-min long intervals at the anaerobic threshold intensity with 75-s rest periods, total work was calculated. Equivalent work was done during continuous exercise. Immediately after the two exercise periods, venous blood lactate, endothelial nitric oxide synthase (eNOS), endothelin-1, N-terminal proANP (NTproANP), N-terminal proBNP (NTproBNP), and N-terminal proCNP (NTproCNP) levels were measured. Brachial artery flow-mediated dilatation (FMD) was measured before exercise and 30 min after exercise. Results: Mean VO2 peak level was 33.42 +/- 5.9 ml/min/kg and anaerobic threshold level was 47.33 +/- 5.85%. Lactate levels following continuous exercise were higher than levels following intermittent exercise (27.76 +/- 7.43 mg/dl, 18.54 +/- 4.87 mg/dl respectively; p.0.05). Endothelin-1, eNOS, NTproANP, NTproBNP, and NTproCNP levels were similar after both modalities of exercise (p > 0.05). No significant difference was found in FMD response when comparing intermittent and continuous exercise (7.05 +/- 15.11%, 2.49 +/- 16.24% respectively; p > 0.05). Conclusion: Since blood lactate levels are higher following continuous exercise, individuals who find difficulty exercising may prefer an intermittent form of exercise. However, both intermittent and continuous exercise at the anaerobic threshold level seem to not produce a significant acute change in endothelial function in healthy men.Öğe Evaluation of Anterior Mediastinal Fat Tissue Density with Computed Tomography in Non-Tymomatous Myasthenia Gravis Patients(2020) Solak, Serdar; Ustabaşıoğlu, Fethi EmreIntroduction: Comparison of anterior mediastinal fat tissue densities between non-thymomatous myasthenia gravis patients and control group with non-contrast thorax computerized tomography.Methods: In this retrospective study, 65 patients with myasthenia gravis, who were examined by non-contrast thorax computerized tomography, were included. A control group consisting of 65 patients with the same sex and similar age distribution as the patient group was composed.Results: Anterior mediastinal fat mass Hounsfield unit average and standard deviation were -97±37.3 for 65 patients withmyasthenia gravis and were -121±37.3 for the control group, respectively. There was a statistically significant difference between Hounsfield unit values and standard deviations between myasthenia gravis patients and the control group (p=0.01).Discussion and Conclusion: In myasthenia gravis patients, anterior mediastinal fat tissue density was found to be higherthan the control group.Öğe Insular cortex involvement in migraine patients with chronic pain: A volumetric radiological and clinical study(Elsevier Sci Ltd, 2024) Mammadkhanli, Orkhan; Kehaya, Sezgin; Solak, Serdar; Yagmurlu, KaanBackground: This study aimed to assess abnormalities in the insular cortex of individuals suffering from migraines and examine their associations with pain duration, medication usage, and clinical symptoms. Methods: We analyzed radiological data from 38 migraine patients who had undergone 3D iso T1-weighted brain MRI at our university hospital between 2019 and 2023. Structured questionnaires were used to collect information on participants' age, migraine type, disease duration, clinical symptoms, and medication use. Volumetric analysis was performed on the insular regions using Volbrain and 3DSlicer. The results were statistically analyzed. Results: Comparing groups with chronic pain to normal groups revealed significant differences in several insular regions, including the posterior insula (p = 0.034), parietal operculum (p = 0.04), and the entire insular cortex (p = 0.023). Further group comparisons (Group 1, 2, and 3) showed significant differences in specific insular regions. For instance, the anterior insula (p = 0.032) was associated with taste changes, the posterior insula (p = 0.010) with smell-related changes, and the central operculum (p = 0.046) with sensations of nausea. Additionally, significant changes were observed in the parietal operculum concerning nausea, photophobia, phonophobia, and changes in smell. Conclusion: To the best of our knowledge, there have been no studies investigating the relationship between clinical manifestations and volumetric correlation. This study provides insights into abnormalities in the insular cortex among migraine patients and their potential relevance to pain duration, severity, and migraine type. The results suggest that understanding alterations in insular regions possibly linked to pain could contribute to the development of innovative approaches to managing chronic pain.Öğe Quantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis of Sjögren’s Syndrome(2020) Ustabaşıoğlu, Fethi Emre; Korkmaz, Selçuk; İlgen, Ufuk; Solak, Serdar; Kula, Osman; Turan, Sezin; Emmüngil, HakanBackground: Primary Sjögren’s syndrome is a chronic inflammatory autoimmune disease. Minor salivary gland biopsy is the gold standard for the diagnosis of primary Sjögren’s syndrome. Superb microvascular imaging, power Doppler ultrasound, and color Doppler of the salivary glands represent non-invasive, non-irradiating modality for evaluating the vascularity of the salivary glands in the diagnosis and follow-up of primary Sjögren’s syndrome. Aims: To evaluate the efficacy of superb microvascular imaging and vascularity index in salivary glands for the sonographic diagnosis of primary Sjögren’s syndrome. Study Design: Prospective case-control study. Methods: Twenty participants with primary Sjögren’s syndrome and 20 healthy subjects were included in the study. Both parotid glands and submandibular glands were evaluated by superb microvascular imaging, power Doppler ultrasound, and color Doppler. The diagnostic accuracy of superb microvascular imaging was compared using these techniques. Results: In the patient group, the vascularity index values of superb microvascular imaging in parotid glands and submandibular glands were 3.5±1.66, 5.06±1.94, respectively. While the same values were 1.0±0.98 and 2.44±1.34 in the control group (p?0.001). In the patient group, the vascularity index values of power Doppler ultrasound in parotid glands and submandibular glands were 1.3±1.20 and 2.59±1.82, respectively. While the same values were 0.3±0.32 and 0.85±0.68 in the control group (p?0.001). The superb microvascular imaging vascularity index cut-off value for the diagnosis of primary Sjögren’s syndrome in parotid glands that maximizes the accuracy was 1.85 (area under the curve: 0.906; 95% confidence interval: 0.844, 0.968), and its sensitivity and specificity were 87.5% and 72.5%, respectively. While the superb microvascular imaging vascularity index cut-off value for the diagnosis of primary Sjögren’s syndrome in submandibular gland that maximizes the accuracy was 3.35 (area under the curve: 0.873; 95% confidence interval: 0.800, 0.946), its sensitivity and specificity were 82.5% and 70%, respectively. Conclusion: Superb microvascular imaging with high reproducibility of the vascularity index has a higher sensitivity and specificity than the power Doppler ultrasound in the diagnosis of primary Sjögren’s syndrome. It can be a noninvasive technique in the diagnosis of primary Sjögren’s syndrome when used with clinical, laboratory and other imaging methods.Öğe The relationship between computed tomographic obstruction index and pulmonary vein cross-sectional area in acute pulmonary embolism(Springer-Verlag Italia Srl, 2020) Ustabasioglu, Fethi Emre; Solak, Serdar; Kula, Osman; Gunay, Burak; Serez, Bilkay; Tuncbilek, NerminPurpose To investigate whether the increased obstruction of the pulmonary arteries was associated with reduced pulmonary vein areas in acute pulmonary embolism (APE). Method We retrospectively analyzed a consecutive series of computed tomography pulmonary angiography studies of 107 patients with APE and 101 controls without APE between November 2010 and January 2019. The control and patient groups were compared with each other for differences between the mean cross-sectional areas of pulmonary veins. Further analysis was conducted by dividing the patient group into high-risk patients (>= 20%) and low-risk patients (< 20%) according to the pulmonary arterial obstruction index. The mean cross-sectional area of the pulmonary veins in these two groups was compared. Results The mean cross-sectional areas of the 4 pulmonary veins at the ostium level (CSAPV) were significantly lower for the patient group (mean: 102.6 mm(2)) compared with the control group (111.8 mm(2)) (p < 0.001). CSAPV cutoff value for determining the diagnosis of APE that maximized the accuracy was 109.12 mm(2) (AUC = 0.721; 95% CI 0.649-0.794); its sensitivity and specificity were 78.2% and 69.2%, respectively. CSAPV cutoff value for differentiating high-risk APE that maximized the accuracy was 102.6 mm(2) (AUC = 0.634; 95% CI 0.525-0.743); its sensitivity and specificity were 61.9% and 53.8%, respectively. Conclusions There is a negative correlation between the CSAPV and thrombotic material burden in the pulmonary arteries of patients with APE. Hence, the CSAPV can be used as a diagnostic tool in the evaluation of the presence and severity of pulmonary embolism.Öğe Retroaortik Seyreden En Yeni ve Uzun Ektopik Sol Ana Koroner Arter ve Klinik Takibi(2020) Taylan, Gökay; Gök, Murat; Gürçağan, Ayhan; Solak, SerdarUzun sol ana koroner arter genellikle tesadüfen görülür. Göğüs ağrısı olan 47 yaşındaki erkek olgumuzda, literatürdeki en yeni ve uzunektopik uzun sol ana koroner arteri sunuyoruz. Uzun sol ana koroner arter , koroner anjiyografide 62-63 mm, koroner bilgisayarlı tomografide60,8 mm olarak ölçüldü.Öğe Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease(Assoc Medica Brasileira, 2022) Taylan, Gokay; Ebik, Mustafa; Solak, Serdar; Kaya, Caglar; Yalta, KenanOBJECTIVE: In the current literature, there are few studies investigating the relationship between premature coronary atherosclerosis and nonalcoholic fatty liver disease. We aimed to evaluate the relationship between nonalcoholic fatty liver disease and premature coronary atherosclerosis. METHODS: In this cross-sectional study, female patients aged <55 years and male patients aged <50 years were enrolled. Both male and female patients underwent coronary angiography and abdomen ultrasonography between 2014 and 2019. A stepwise binary logistic regression analysis was carried out to evaluate the independent variables related to premature coronary atherosclerosis and nonalcoholic fatty liver disease. A p-value<0.05 was considered statistically significant. RESULTS: nonalcoholic fatty liver disease was present in 44% of patients (n=377). Notably, 62% of the patients were female and the mean age was 44.5 (39-49) years. In a multivariate analysis, nonalcoholic fatty liver disease was shown to be an independent risk factor of premature coronary atherosclerosis (OR 1.438; 95%CI, 1.050-1.969; p=0.024). CONCLUSIONS: The presence of nonalcoholic fatty liver disease is an important independent risk factor for the development of premature coronary atherosclerosis.Öğe The Role of Superb Microvascular Imaging and Shear Wave Elastography in the Prediction of Hemorrhage Complications After Renal Parenchyma Biopsy(Lippincott Williams & Wilkins, 2023) Gunay, Burak; Uslu, Burak; Celik, Ahmet Onur; Korkmaz, Selcuk; Ustabasioglu, Fethi Emre; Solak, Serdar; Kula, OsmanObjectives: The aim of study was to evaluate the diagnostic utility of the renal parenchyma elasticity with the shear wave elastography (SWE) and microvascularization with the superb microvascular imaging (SMI) technique before kidney biopsy and to predict the complication of hemorrhage before kidney biopsy.Methods: A total of 75 patients were included in the prospective study. Before the biopsy, vascularity features of the kidney parenchyma in the area to be biopsied were assessed by SMI and parenchymal stiffness by SWE and were examined by 2 independent radiologists.Results: A statistically significant difference was found in the SMI and SWE values between the groups with and without hematoma and hematuria when compared with the Student t test and Mann-Whitney U test (P < 0.05). The SWE hardness cutoff value, which maximizes the prediction of the development of hematuria, was found to be 18.40 kPa, and the sensitivity and specificity values were 84.4% and 62.8%, respectively. In SMI vascularity index values, the cutoff value was found to be 0.247410800 kPa, and sensitivity and specificity values were 81.3% and 83.7%, respectively. The cutoff value of the SMI vascularity index values that maximized the prediction of hematoma development was 0.297009650, and the sensitivity and specificity values were 87% and 87%, respectively.Conclusions: We believe that evaluating and standardizing the microvascularization and elasticity of the kidney parenchyma before a percutaneous kidney biopsy will be potentially useful as a guiding method in the prediction of postbiopsy hemorrhage development.Öğe Ultrasound evaluation of stiffness and vascularity of renal parenchymal damage secondary to hydronephrosis in pediatric patients using shear wave elastography and superb microvascular imaging(Wiley, 2024) Gunay, Burak; Solak, Serdar; Ustabasioglu, Fethi Emre; Kula, Osman; Karabulut, Derya; Tuncbilek, NerminAims: The purpose of this study is to assess the diagnostic value of SWE (shear wave elastography) and renal parenchymal elasticity and microvascularization with the SMI (super microvascular imaging) technique in diagnosing and predicting the progression of renal parenchymal damage in pediatric patients with hydronephrosis. Patients and Methods: A total of 45 patients were included in the prospective study. To evaluate parenchymal changes, SWE and SMI-Vacularity Index (VI) measurements were performed in various sections of the affected and normal kidneys. The affected and control renal pelvises' anteroposterior (AP) diameters were also measured. Results: The average SWE values were measured as 16.62 kPa for the affected kidneys, whereas the control kidneys showed an average SWE value of 12.70 kPa, indicating a statistically significant difference (p < .01). Furthermore, in the affected kidneys, the average SMI-VI value was measured as 5.92, whereas the control kidneys exhibited a higher average SMI-VI value of 6.64, showing a statistically significant difference (p < .01). A reverse correlation was found between renal pelvis AP diameter and SMI-VI values, while a positive correlation existed between renal pelvis AP diameter and SWE values. Conclusions: We believe that SWE and SMI may be useful for diagnosing and predicting the progression of renal parenchymal damage in pediatric hydronephrotic patients.
