Yazar "Sivri, Nasir" seçeneğine göre listele
Listeleniyor 1 - 20 / 29
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Acute coronary syndromes in the setting of acute infections: Is there an overdiagnosis with overtreatment?(Elsevier Ireland Ltd, 2011) Yalta, Kenan; Sivri, Nasir; Yetkin, Ertan[Abstract Not Available]Öğe Anticoagulation in Patients With Left Ventricular Systolic Dysfunction and Sinus Rhythm: When?(Sage Publications Inc, 2014) Sivri, Nasir; Yetkin, Ertan; Tekin, Gulacan Ozgun; Yalta, Kenan; Waltenberger, JohannesLeft ventricular (LV) systolic dysfunction and chronic systolic heart failure (HF) predispose to intraventricular thrombus formation and embolization resulting in stroke. Current guideline recommends the use of oral anticoagulants in patients with atrial fibrillation and history of previous thromboembolism. However, anticoagulant treatment in patients with LV systolic dysfunction with sinus rhythm and without history of previous thromboembolism is still on debate. Recent epidemiologic date has reported increased stroke rate in patients with systolic HF shortly after diagnosis. This review focuses on the possible causes of increased stroke rate shortly after the diagnosis of HF and subsequently suggests a rationale for the use of oral anticoagulant in these patient groups.Öğe Association of Angiotensin II Type 1 Receptor A1166C Gene Polymorphisms with Coronary Artery Disease in Thrace Region of Turkey(Erciyes Univ Sch Medicine, 2021) Taylan, Gokay; Palabiyik, Orkide; Ozkalayci, Flora; Yilmaztepe, Mustafa Adem; Sivri, Nasir; Aksoy, YukselObjective: Although the risk factors for coronary artery disease (CAD) are well established, a significant gap still exists in understanding the pathology of atherosclerotic heart disease evolving without conventional risk factors. Therefore, genetic factors are considered to play a significant role in this setting. The present study aimed to assess the relationship between angiotensin 2 type 1 receptor (AT1R) A1166C gene polymorphism and CAD. Materials and Methods: Patients with documented CAD (n=121) were compared with controls with normal coronary arteries (n=121). CAD was diagnosed using a coronary angiography. The median age of participants was 59 +/- 12 years with an equal sex distribution. A comparison between the two groups with regard to the AT1R A1166C gene polymorphism was made through the amplification of DNA using polymerase chain reaction. Results: This study demonstrated that adenine-adenine and cytosine-cytosine (CC) genotypes were more frequent, yet adenine-cytosine genotype was less frequent among patients with CAD compared with controls [p=0.003), 95% confidence interval (CI)]. The AT1R A1166C gene polymorphism along with the CC genotype and C allele was found to be associated with CAD. Further, gender, hypertension, family history, age, and low levels of serum high-density lipoprotein also had a significant relationship with AT1R A1166C gene polymorphism. Conclusion: The present study suggested AT1R A1166C gene polymorphism, CC genotype, and C allele as potential risk factors for atherosclerotic CAD. Patients harboring these genetic variants should be under close supervision for the development of CAD.Öğe Bone mineral density: A potential determinant of atherosclerotic plaque morphology in established coronary artery disease?(Elsevier Ireland Ltd, 2011) Sivri, Nasir; Yalta, Tulin; Yalta, Kenan; Yetkin, Ertan; Aksoy, Yuksel[Abstract Not Available]Öğe Carotid intima-media thickness:. a new marker of patients with uterine leiomyoma(Elsevier, 2014) Aksoy, Yuksel; Sivri, Nasir; Karaoz, Banu; Sayin, Cenk; Yetkin, ErtanObjective: To determine whether or not there are any significant differences in carotid intima-media thickness between patients with uterine leiomyoma and controls. Study Design: Patients whose ages were between 40 and 50 years, with body mass index <30 kg/m(2), and with a pathological diagnosis of uterine leiomyoma constituted the study group. Control subjects had no uterine leiomyoma proven by sonography. Demographic, clinical, and drug history data were collected. Right, left and mean carotid intima-media thickness measurements were obtained by ultrasonography. Results: Carotid intima-media thickness and serum high-density lipoprotein (HDL) levels were significantly different between the groups (p = 0.0001 and p = 0.001 respectively), being respectively higher and lower in the leiomyoma group than in controls. Stepwise binary logistic regression analysis revealed that uterine leiomyoma development ratio was 159.32 times higher when carotid intima-media thickness was over 0.61 mm (p = 0.0001). In patients with uterine leiomyoma, carotid intima-media thickness was significantly less in patients taking statins compared to those not on these drugs (p = 0.0001). Conclusion: The present study demonstrated a positive association between carotid intima-media thickness and the presence of uterine leiomyoma. Conversely, an inverse association was suggested between HDL and uterine leiomyoma. These findings suggest that women with uterine leiomyoma might have an increased risk of subclinical atherosclerosis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Öğe Chronotropic incompetence: An obscure cause of heart failure symptoms in survivors of critical diseases?(Elsevier Ireland Ltd, 2011) Yalta, Kenan; Yalta, Tulin; Sivri, Nasir; Aksoy, Yuksel; Yetkin, Ertan[Abstract Not Available]Öğe Copeptin (C-terminal provasopressin): A promising marker of arrhythmogenesis in arrhythmia prone subjects?(Elsevier Ireland Ltd, 2011) Yalta, Kenan; Sivri, Nasir; Yalta, Tulin; Geyik, Bilal; Aksoy, Yuksel; Yetkin, Ertan[Abstract Not Available]Öğe Copeptin and cardiovascular disease: A review of a novel neurohormone(Elsevier Ireland Ltd, 2013) Yalta, Kenan; Yalta, Tulin; Sivri, Nasir; Yetkin, ErtanNeurohormones (NHs) in the cascade of the arginine vasopressin (AVP) system have drawn particular attention in the recent years. Copeptin, the C-terminal portion of provasopressin, is a novel NH of the AVP system, and is known to be co-released with AVP from hypothalamus (neurohypophysis). As a surrogate marker of the AVP system, copeptin has gradually replaced AVP in several clinical studies largely due to its structural and methodological advantages. Copeptin has been regarded as a marker of non-specific stress response, and has also been suggested to have clinical implications in a variety of non-cardiovascular (pneumonia, sepsis, etc.) and cardiovascular conditions (heart failure and acute coronary syndromes (ACSs, etc.)). However, current data on relation of copeptin with other cardiovascular conditions (arrhythmias, etc.) are still insufficient. The present review primarily focuses on general features of copeptin, its general clinical implications, and specifically aims to cover its potential clinical value in a variety of cardiovascular conditions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.Öğe Coronary Artery Ectasia is Associated with the Elevation of Mean Platelet Volume Regardless of an Existing Acute Coronary Syndrome(Aves, 2013) Sivri, Nasir; Yalta, Tulin; Yalta, Kenan; Altun, Armagan; Sut, Necdet; Yetkin, ErtanObjective: Elevated mean platelet volume (MPV) has been considered as an indicator of enhanced platelet reactivity. In several studies, MPV has been shown to be elevated in the setting of acute coronary syndromes (ACS) and coronary artery ectasia (CAE). In this study we aimed to investigate the potential effects of CAE on MPV regardless of an existing acute coronary syndrome (ACS). Methods: Two independent operator retrospectively reviewed the records of 12,724 patients who had previously (between the years 2000 and 2011) undergone coronary angiography in the catheterization laboratory. The present study comprised an overall 337 patients including 112 patients with stable coronary artery disease (CAD) (group 1), 112 patients with ACS (group 2) and 113 patients with isolated CAE (without ACS) (group 3). Results: The values of mean ages were 52.3 +/- 5.6; 52.5 +/- 5.7 and 49.7 +/- 3.8 in groups 1, 2 and 3, respectively (p< 0.001). Cardiovascular risk factors and hemoglobin levels did not significantly differ among groups. Mean platelet levels in groups 2 and 3 (244.8 +/- 28.3, 239.1 +/- 28.8, respectively) were found to be significantly lower than that of group 1 (276.4 +/- 0.69) (p< 0.001) whereas mean levels of MPV in groups 2 and 3 (9,09 +/- 1.07fL, 9.06 +/- 1.07fL, respectively) were found to be significantly higher than that of group 1 (8,56 +/- 1.28fL) (p< 0.001). Conclusion: Nothwithstanding the similar cardiovascular risk factors and admission patterns suggestive of a common etiopathological background among these 3 entities, MPV levels may be more likely to be elevated in the setting of ACSs and isolated CAE (regardless of an existing ACS) compared to stable CAD.Öğe Coronary slow flow: a potential prognostic marker correlating with the disease severity in renal failure?(Oxford Univ Press, 2010) Yalta, Kenan; Yilmaz, Mehmet Birhan; Yalta, Tulin; Sivri, Nasir; Refiker, Meltem[Abstract Not Available]Öğe Coronary syndrome Y: Should we focus more on extra-cardiac conditions including renal disease and its management?(Elsevier Ireland Ltd, 2011) Yalta, Kenan; Yilmaz, Mehmet Birhan; Yalta, Tulin; Sivri, Nasir; Yucel, Oguzhan[Abstract Not Available]Öğe Effects of patients anxiety and depression scores on coronary flow in patients with normal coronary arteries(Elsevier Ireland Ltd, 2015) Yalvac, Dilek; Ozturk, Selcuk; Sivri, Nasir; Kilic, Yasemin; Bulut, Eda; Celik, Arzu; Barlas, Yesim[Abstract Not Available]Öğe Extensive coronary arterial calcification: An over-adaptive phenomenon against complications of atherosclerosis?(Elsevier Ireland Ltd, 2011) Yalta, Kenan; Yalta, Tulin; Yucel, Oguzhan; Sivri, Nasir[Abstract Not Available]Öğe Golden Ratio is beating in our heart(Elsevier Ireland Ltd, 2013) Yetkin, Gulay; Sivri, Nasir; Yalta, Kenan; Yetkin, Ertan[Abstract Not Available]Öğe Headache response to nitrate in patients with coronary artery disease and systolic heart failure(Elsevier Ireland Ltd, 2012) Sivri, Nasir; Tekin, Gulacan; Erbay, Ali Riza; Yalta, Kenan; Senen, Kubilay; Guer, Mustafa; Yetkin, Ertan[Abstract Not Available]Öğe Incremental effects of restless legs syndrome on nocturnal blood pressure in hypertensive patients and normotensive individuals(Lippincott Williams & Wilkins, 2012) Erden, Emine C.; Erden, Ismail; Turker, Yasin; Sivri, Nasir; Dikici, Suber; Ozsahin, MustafaBackground Few studies have evaluated the role of restless legs syndrome (RLS) in the development of nondipping 24 h blood pressure (BP) patterning/sleep-time hypertension, which has been shown to be an independent predictor of cardiovascular risk. These were indirect studies that had reported the relation between BP and RLS attacks during polysomnographic investigations in the lab. The aim of the present study was to assess the relationship between RLS, which was diagnosed clinically, and night-time BP patterns in a relatively large young cohort who had not been treated before. Patients and methods After applying the exclusion criteria, this cross-sectional study included 230 consecutive patients with never-treated hypertension who presented to our institution for initial evaluation of hypertension. RLS was assessed using a self-administered questionnaire based on the International Restless Legs Study Group criteria. The questions on RLS were completed by 214 patients and ambulatory BP monitoring was carried out for all patients. Results In the study group, 133 patients were diagnosed as hypertensive (53.4% nondippings) and 81 patients as normotensives (54.3% nondippings). RLS was present in 61 patients (28.5%) in the total sample. The prevalence of RLS, overall, was significantly higher in nondippings compared with dippings (34.7 vs. 21.2%, respectively; P = 0.028). Logistic regression analysis showed that the RLS is an independent determinant for both hypertension (odds ratio = 0.43, 95% confidence interval = 0.21-0.83; P = 0.013) and the nondipping BP patterns (odds ratio = 1.96, 95% confidence interval = 1.05-3.67; P = 0.035). Conclusion We have shown that clinically diagnosed RLS was associated with the nondipping pattern, which has been shown to be an independent predictor of cardiovascular risk. Blood Press Monit 17:231-234 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. Blood Pressure Monitoring 2012, 17:231-234Öğe Investigation of Angiotensinogen M235T and T174M Gene Polymorphisms in Coronary Artery Disease(Erciyes Univ Sch Medicine, 2021) Yamasan, Bilge Eren; Gulyasar, Tevfik; Sipahi, Tammam; Sivri, Nasir; Palabiyik, OrkideObjective: Coronary artery disease (CAD) is a multifactorial disorder and is caused by both environmental and genetic factors. As the alterations in angiotensinogen (AGT) gene lead to changes in angiotensin II and plasma levels of AGT, variants of this gene may play a role in CAD pathogenesis. This study aimed to investigate the relationship between CAD and polymorphisms of AGT gene at M235T and T174M regions. Moreover, the associations of potential risk factors with these gene regions and CAD were investigated. Materials and Methods: In total, the study enrolled 214 cases with CAD and 200 controls. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to detect polymorphisms at M235T and T174M. PCR products were electrophoresed on 2% agarose gel, with ethidium bromide, and were then examined under ultraviolet light. Subsequently, RFLP was used to detect gene polymorphisms. A multiple binary logistic regression model was used to investigate the association of risk factors with both CAD and AGT variants. Results: The number of TT polymorphisms at M235T were significantly higher in the case group than in control group. However, there were no significant differences between cases and controls regarding T174M gene polymorphisms. The presence of hypertension, low high-density lipoprotein level, alcohol consumption, and family history were associated with CAD. Conclusion: TT polymorphisms at the M235T region in AGT can be an influential factor in the development of CAD.Öğe Mean Platelet Volume in Patients With Dilated Cardiomyopathy: Does it have a Role in Left Ventricular Thrombus Formation?(Sage Publications Inc, 2012) Tekin, Gulacan; Sivri, Nasir; Tekin, Yusuf Kenan; Topal, Ergun; Erbay, Ali Riza; Yetkin, ErtanWe assessed the clinical echocardiograhic, hematological, and biochemical parameters in patients with dilated cardiomyopathy (DCMP) and control individuals mainly focusing on the mean platelet volume (MPV) in terms of DCMP and left ventricle (LV) thrombus formation. Consecutive patients (n = 251) with DCMP and 266 patients without DCMP were studied. Mean platelet volume was significantly greater in patients with DCMP than in control patients (P < .05 for all comparisons). Comparing DCMP patients with LV thrombus (19 patients, 8%) and without LV thrombus (232 patients, 92%) showed that the prevalence of smokers was significantly higher and ejection fraction was significantly lower in patients with LV thrombus. We have shown that patients with DCMP have significantly higher MPV suggesting more platelet activation and the MPV of patients with DCMP and LV thrombus is comparable to those of patients without LV thrombus.Öğe Mean platelet volume in patients with nonvalvular atrial fibrillation(Lippincott Williams & Wilkins, 2013) Tekin, Gulacan; Tekin, Yusuf Kenan; Sivri, Nasir; Yetkin, ErtanThe procoagulant and prothrombotic states in patients with chronic atrial fibrillation are higher than those in patients with normal sinus rhythm. Mean platelet volume (MPV) which is a marker of platelet function and activation can reflect changes either in the level of platelet stimulation or the rate of platelet production. In this study, we aimed to assess and compare the hematologic parameters of routine complete blood count analysis in elderly patients with nonvalvular atrial fibrillation and control individuals with normal sinus rhythm. One hundred and seven consecutive patients with nonvalvular chronic atrial fibrillation and 112 age and sex-matched control individuals with normal sinus rhythm were retrospectively included in the study from the outpatient cardiology clinic. Hematological variables, including MPV, platelet count, red blood cell and white blood cell count were measured in all patients and control individuals. Presence of coronary artery disease, hypertension, sex, hyperlipidemia, diabetes mellitus, smoking status, hematocrit and platelet count were comparable between two groups (P>0.05 for all). However, MPV and white blood cell count were significantly higher in patients with atrial fibrillation compared to those without atrial fibrillation. Logistic regression analysis revealed that white blood cell count and MPV significantly and independently associated with atrial fibrillation. We have shown that MPV and white blood cell count is independently associated with chronic nonvalvular atrial fibrillation. To improve the clinical utility of MPV and role of inflammation in the pathogenesis of atrial fibrillation, further studies are needed to be carried out. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.Öğe Meteorologic factors may trigger arrhythmogenesis through induction of systemic inflammation and coagulation response: Potential antiarrhythmic benefits of mitigating this response in arrhythmia-prone subjects under poor meteorologic conditions?(Elsevier Ireland Ltd, 2013) Yalta, Kenan; Geyik, Bilal; Sivri, Nasir; Yetkin, Ertan[Abstract Not Available]
