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Öğe Can myometrial thickness/cervical length ratio predict preterm delivery in singleton pregnancies with threatened preterm labor? A prospective study(Springer Heidelberg, 2019) Erzincan, Selen Gursoy; Sayin, N. Cenk; Korkmaz, Selcuk; Sutcu, Havva; Inan, Cihan; Cilingir, Isil Uzun; Varol, Fusun G.ObjectiveTo investigate whether myometrial thickness (MT) to cervical length (CL) ratio could be used in the prediction of preterm birth (PTB) in singleton pregnancies presented with threatened preterm labor (TPL).MethodsAfter 48h of successful tocolysis, MT was measured transabdominally from the fundal, mid-anterior walls and the lower uterine segment (LUS) in 46 pregnancies presented with TPL. MT measurements were divided into CL, individually. The main outcome was PTB before 37weeks of gestation.ResultsThe patients were divided into two groups as women delivered37weeks (38.681.01weeks) (n=25) and those delivered<37weeks (34.28 +/- 2.53weeks) (n=21). The mean +/- SD CL in the preterm delivery group was significantly shorter than the term delivery group (23.77 +/- 9.23 vs 29.91 +/- 7.03mm, p<0.05). Fundal, mid-anterior or LUS MT values were similar in both groups. However, in those who delivered preterm, the ratios of fundal MT-to-CL (p=0.026) and mid-anterior MT-to-CL (p=0.0085) were significantly different compared to those delivered at term. The optimal cutoff values for CL, fundal MT-to-CL and mid-anterior MT-to-CL ratios in predicting PTB were calculated as 31.1mm, 0.19 and 0.20, respectively. Fundal MT-to-CL ratio predicted preterm delivery with 71% sensitivity, 72% specificity, 68% positive and 75% negative predictive values. For mid-anterior MT-to-CL ratio, respective values were 76, 76, 73 and 79%.Conclusion p id=Par4 Measurement of MT along with CL may offer a promising method in the management of women presented with TPL.Öğe Clinical Significance of Abnormal Results of Second Trimester Hormones in the Absence of Aneuploidy(Kowsar Publ, 2018) Uzun, Isil; Sayin, N. Cenk; Inan, Cihan; Erzincan, Selen; Sutcu, Havva; Varol, FusunBackground: Abnormal levels of hormones during the second trimester of pregnancy may predict genetic disorders and complications of pregnancy. Objectives: This study was performed to evaluate the clinical significance of abnormal results in second-trimester markers in the absence of aneuploidy. Methods: This case-control study was conducted between May 2014 and December 2015 in the maternal-fetal unit, Trakya University Faculty of Medicine in Turkey. Overall, 108 Turkish pregnant females were included in this study. This research recruited patients (n = 46) with normal karyotype, who underwent invasive prenatal tests because of abnormal levels of second-trimester hormones, along with a cohort of controls (n = 31) with hormonal results within normal ranges. For each patient, the researchers recorded the mode of delivery, gestational age at delivery, birth weight, complications, and adverse outcome of the pregnancy. Data were analyzed using Fisher's exact tests and Yates continuity correction tests for qualitative variables, and t- test and Mann-Whitney U test for quantitative variables. Results: Maternal age (mean +/- SD) of the entire group was 31.77 +/- 5.68 years (study group: 31.23 +/- 4.39; controls: 32.13 +/- 6.43, P > 0.05). Preterm delivery and preeclampsia were significantly higher in the study group (P = 0.02). In the study group, Alpha Fetoprotein (AFP) levels were significantly higher in patients with preeclampsia yet not in the controls. The AFP values under 0.77 multiple of the median in patients with elevated test results in the absence of aneuploidy appeared to be associated with the development of preeclampsia later in pregnancy. Conclusions: Although the significance of higher AFP values have been discussed in the literature in terms of the development of adverse outcomes, the present study suggests that lower values must also be taken into account during patient follow-up.Öğe The clinical value of avidity test in the management of serologic rubella infection: a case report(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2007) Sayin, N. Cenk; Ahmet, Nefise; Varol, Fuesun G.28-year-old pregnant woman presented with positive rubella IgM and IgG antibodies at initial admission and at the 11th, 13th, 30th and 36th weeks of gestation. Rubella avidity test revealed high titers and the patient was followed-up to ensure birth of a healthy infant. Rubella infection may be asymptomatic and re-infection may demonstrate a subclinical course. It is easy to make the diagnosis of rubella by following the antibody titers during pregnancy. The critical point in such patients is to differentiate the condition of disease at admission and decide accordingly. Avidity test may be a useful method for the management of such patients.Öğe Conjoined Twins: Unicephalus Non-Janiceps Tetrapus Tetrabrachius(Springer India, 2022) Yener, Cem; Sayin, N. Cenk; Altan, Esra; Varol, FusunConjoined twins are an uncommon type of monoamniotic twins with an incidence of about 1.5 per 100,000 births worldwide. Non-janiceps is the extremely rare sub-type of cephalopagus which is reported as 1 in 58 of all conjoined twins or 1 in 3 million births. We present a G6, P5 31-year-old pregnant who was diagnosed with a unicephalus non-janiceps conjoined twins. Due to its incompatibility with life, the pregnancy was electively terminated. The prognosis of conjoined twins depends on the location and extent of the conjoined area and the accompanying congenital anomalies of the fetuses. Early diagnosis is vital because it can help in assessing the type of conjoined twins and subsequently pre-postnatal decision making. Elective termination of non-janiceps type of conjoined twins which is incompatible with life is a justifiable possibility.Öğe Correlation Between Maternal Plasma Thrombomodulin and Infant Birth Weight in Hypertensive Disorders of Pregnancy(Sage Publications Inc, 2009) Varol, Fuesun G.; Ozgen, Levent; Sayin, N. Cenk; Demir, MuzafferObjective: To evaluate the association between maternal plasma thrombomodulin levels and infant birth weights in pregnancy-induced hypertension. Study design: Plasma thrombomodulin levels were measured in 80 pregnat women living in the Trakya region of Turkey. Kruskal-Wallis statistical analysis was performed in comparison of the descriptive and laboratory data (significance at P<.05). Results: The plasma thrombomodulin values in hypertensive disorders in pregnancy were found to be highly correlated with the infant birth weights(P<.001). Conclusion: Elevated plasma thrombomodulin levels in hypertensive disorders of pregnancy were well correlated withh related infant birth weights of these pathhologies. Plasma thrombomodulin levels might point out placental vascular endothelial damage reflecting on infant birth weights.Öğe Do routine preoperative imaging techniques facilitate the operation in endometrial cancer?(Springer Heidelberg, 2009) Sayin, N. Cenk; Varol, Fuesun G.; Yuce, M. Ali; Kaplan, Petek; Ahmet, Nefize; Sut, Necdet; Gucer, FatihTo assess the role of routine intravenous pyelography (IVP), rectoscopy and additional imaging techniques like computed tomography (CT) and abdominal ultrasonography (USG) for the evaluation of patients with endometrial cancer. A total of 97 women with endometrial cancer (82 endometrioid and 15 non-endometrioid type) of all stages (Stage I = 65, II = 14, III = 13, IV = 5) were included in the study. Of these, 50 women were admitted because of postmenopausal bleeding, 24 with irregular vaginal bleeding and 7 with pain and leucorrhea, whereas the others had no complaints. Only one patient had symptoms related to the gastrointestinal system, but none for the urinary system. Preoperative CT (n = 45), IVP (n = 78), rectoscopy (n = 46), and USG or colonoscopy (n = 37) were performed on our patients. All the women had total abdominal hysterectomy and bilateral salpingo-oophorectomy, with/without pelvic (n = 81) and paraaortic (n = 34) lymphonodectomy, and omentectomy (n = 35). In 39 of 45 women who had CT, it had no effect on the operation and did not facilitate the operation. In two women there were pathological findings on CT and some interventions (resection and anastomosis) were performed on the gastrointestinal tract in these patients. However, CT had overcome pathological findings related with the gastrointestinal or urinary systems in four women, who needed interventions to these systems during the operation. CT was not performed on six women who needed interventions to the gastrointestinal system during the operations. Three patients had pathological findings (fissure, external compression) in rectoscopy, but only one patient had ileo-transverstomy, in which rectoscopic finding had not predicted the necessity of that procedure. Out of 78 IVP, the only finding was external compression to the bladder in 38 patients, and this finding had no contribution to the operation. Among women who had USG or colonoscopy (n = 37) performed, five had pathological findings that contributed to the extensiveness or the mode of the operations (liver nodules, polyps in the colon). Routine preoperative computed tomography, intravenous pyelography, rectoscopy or abdominal USG and colonoscopy have little impact on the decision and the prediction of the extensiveness of the operation.Öğe Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies(Wiley, 2018) Inan, Cihan; Sayin, N. Cenk; Dolgun, Zehra N.; Erzincan, Selen G.; Uzun, Isil; Sutcu, Havva; Sut, NecdetObjective: To evaluate the possible effects of prenatal steroid administration onDoppler parameters of the umbilical artery, uterine artery, middle cerebral artery, and ductus venosus, the cerebroplacental ratio, and the amniotic fluid index in pretermfetuses. Methods: The present prospective observational study was performed at the Perinatology Department of Trakya University, Edirne, Turkey, between June 1, 2015, and September 1, 2016. It included patients with healthy singleton pregnancies who had received betamethasone at 24-34 weeks of pregnancy. Doppler parameters were measured before (0 hours) and 24, 48, and 72 hours after the administration of betamethasone (two intramuscular doses of 12 mg each, administered 24 hours apart). Results: There were 68 patients included. Pairwise comparisons demonstrated that, at 72 hours after betamethasone administration, the umbilical artery resistance index (P=0.038), the middle cerebral artery systolic/diastolic velocity ratio (P=0.007), and the amniotic fluid index (P=0.017) were reduced, whereas the end-diastolic velocity of the middle cerebral artery was increased (P=0.012), compared with baseline values. Conclusion: Betamethasone had favorable effects on fetal cerebral circulation, with increased end-diastolic velocity in the middle cerebral artery; this could represent a positive effect on cerebral blood circulation and decreased flow resistance in the umbilical artery.Öğe The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor(Elsevier Science Bv, 2010) Sayin, N. Cenk; Arda, Sezer; Varol, Fusun G.; Sut, NecdetObjective: To determine the effects of ritodrine and magnesium sulfate on maternal-fetal blood flows. Study design: A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to receive either ritodrine (with the addition of verapamil) (n = 46) or magnesium sulfate (n = 39). Blood flow examinations on the umbilical artery (UA), middle cerebral artery (MCA), bilateral uterine arteries (Ut.A) and ductus venosus (DV) were performed before and 48 h after initiating therapy. Results: UA pulsatility index (PI) significantly differed in women receiving tocolysis compared to controls after 48 h. DV PI increased in women receiving MgSO(4), whereas it decreased in the ritodrine and control groups. Ut.A values did not significantly change after 48 h in the groups. In women between the 26th and 32nd weeks, UA, MCA and DV PI did not significantly change after 48 h in the three groups. However, in women between the 32nd and 36th weeks UA and MCA PI significantly differed in the treatment groups compared to controls after 48 h. DV PI increased in women receiving MgSO4, whereas it decreased in the ritodrine and control groups. Conclusions: MgSO4 and ritodrine affect blood flow patterns after 48 h in some maternal-fetal vessels. These effects on blood flow are particularly significant in women between 32nd and 36th weeks. The effects of both drugs on fetal and maternal Doppler flows seem similar, except the increased resistance to flow in DV in women receiving MgSO4. Crown Copyright (c) 2010 Published by Elsevier Ireland Ltd. All rights reserved.Öğe Efficacy of Alpha-methyldopa and Nifedipine in the Treatment of Postpartum Hypertension(Galenos Yayincilik, 2005) Sayin, N. Cenk; Altunda, Gonul; Varol, Fusun G.Objective: To evaluate the efficacy of alpha-methyldopa and nifedipine on postpartum hypertension in women who had various hypertensive disorders of pregnancy. Materials and Methods: A total of 83 women with preeclampsia, eclampsia and superimposed preeclampsia on chronic hypertension who had delivered in our department and also exhibited persistent hypertension over 160/110 mmHg after the postpartum 24th hours were included in the study. The patients were randomly divided into two groups. The patients in Group 1 (n=41) received alpha-methyldopa (750 mg/d) and in Group 2 (n=42) nifedipine (40 mg/d) in divided doses. Another antihypertensive drug was added to the therapy if the therapy was insufficient, and a third if needed. Antihypertensive therapy was discontinued after normotensive values were observed after 48 hours during therapy. The number of drugs were lessened and then discontinued in women taking two or more antihypertensive drugs. Mann-Whitney U and Chi-squaretests were applied for statistical analysis. Results: The patients were 17 to 41 years old, and the mean +/- SD age was similar between two groups (28.1 +/- 5.9 vs. 27.1 +/- 5.9 years, P=0.48). Women in Group 1 required antihypertensive therapy for 8.6 +/- 5.5 days, whereas Group 2 patients required therapy for 6.7 +/- 2.5 days (P=0.13). Twenty-one patients (51.2%) taking alpha-methyldopa did not need another antihypertensive drug, however 19 women (46.3%) received two and one patient (2.4%) received three different antihypertensive drug combinations. Twenty-nine patients (69%) taking nifedipine did not need another antihypertensive drug, however 11 women (26.1%) received two and two patients (4.7%) received three different antihypertensive drug combinations. There was no significant difference in single agent (P=0.15), double agent (P=0.09) or triple agent (P=1) antihypertensive therapy between two groups. Conclusion: Nifedipine and alpha-methyldopa treatment had similar effectiveness on postpartum hypertension in women with various hypertensive disorders of pregnancy. Also, the required duration of antihypertensive therapy was short.Öğe Efficiency of Cervical Sonography for the Determination of Preterm Birth in Singleton and Twin Pregnancies After 25 Weeks' Gestation(Galenos Yayincilik, 2005) Sayin, N. Cenk; Varol, Fusun G.; Yilmaz, Ozlem; Kurt, ImranObjective: To evaluate the efficiency of cervical sonography in determination of preterm birth in singleton and twin pregnancies. Materials and Methods: A total of 78 women (56 with singleton and 22 with twin pregnancies) with preterm labor who were admitted to our department between 25 and 36 weeks' gestation were enrolled in the study. Cervical length and the presence of cervical funneling were evaluated by transvaginal sonographic scan. For singleton and twin pregnancies reaching >= 37 and >= 34 weeks' gestation respectively, were accepted as good perinatal outcome. The cut-off values for cervical length were set at <35 mm for singleton and <25 mm for twin pregnancies. Results: Sonographic evaluation and delivery weeks for singleton and twin pregnancies were 33 (25-36) and 36 (26-40) weeks, and 31 (25-33) and 34 (31-36) weeks, respectively. A cervical length <35 mm for singleton pregnancies, <25 mm for twins have 67.9% and 57.1% sensitivity, 46.4% and 86.7% specificity, 55.9% and 66.7% positive predictive and 59.1% and 81.3% negative predictive values for the determination of preterm birth, respectively. The presence of cervical funneling for singleton and twin pregnancies determined preterm birth with sensitivity of 83.3% and 55.6%, specificity of 50% and 84.6%, positive predictive value of 44.1% and 71.4%, negative predictive value of 86.4% and 73.3%, respectively. Conclusion: Cervical sonography after 25 weeks' gestation can determine preterm birth with high sensitivity and negative predictive value in twin pregnancies presented with preterm labor. However, for singleton pregnancies the presence of cervical funneling has high sensitivity and negative predictive values for the determination of preterm birth.Öğe Fetal cloacal dysgenesis sequence presented with first trimester megacystis and associated umbilical cord abnormalities(Wiley, 2020) Erzincan, Selen Gursoy; Sayin, N. Cenk; Inan, Cihan; Uzun, Isil; Ugurlar, Ozge Yapici; Varol, Fusun G.Cloacal dysgenesis sequence occurs as a result of complete developmental failure of the urorectal septum. Typically, the sequence is featured by a smooth perineum, without any urethral, genital or anal openings. Its clinical manifestation differs throughout gestation. We report an interesting case of first trimester megacystis with associated umbilical cord abnormalities in a female fetus having cloacal dysgenesis sequence. This rare association reflecting high urinary pressure should first suggest urethral atresia. Our case highlights the importance of routine inspection of umbilical cord in the workup of early megacystis in terms of both etiology and fetal diagnosis.Öğe Maternal and fetal outcomes in pregnancies with pulmonary hypertension: Experience of a tertiary center(Elsevier Taiwan, 2018) Dolgun, Zehra Nihal; Inan, Cihan; Sayin, N. CenkObjective: Pregnancies complicated with PHT are serious debates for obstetricians due to high maternal and fetal complication potentials. The aim of the study was to present our maternofetal outcomes in pregnant women with pulmonary hypertension. Materials and methods: This study was performed using data extracted from the medical files of 23 pregnancies of 18 patients with PHT who were followed-up in the obstetrics and gynecology department. Results: The average age was 27.09 +/- 6.97 (range: 14-38) years. The most frequent maternal cardiac pathologies were cardiac valvular disease (mitral or aortic insufficiency) (n = 4), atrial septal defect (n = 3), mitral stenosis (n = 3), ventricular septal defect (n = 2) and arrhythmia (n = 2). Caesarean section and normal vaginal delivery were performed in 13 and 7 deliveries, respectively. Therapeutic dilatation and curettage was performed in 3 patients. Preterm delivery occurred in 4 pregnancies and there were 2 intrauterine growth retardations, 1 preeclampsia and 2 maternal pulmonary edemas. One patient underwent re-laparotomy 5 days after delivery due to uterine hematoma. Totally, 20 newborns (14 female, 6 male) were delivered. Most of the complications were seen in advanced PHT classes. Conclusion: The care of the pregnant women with PHT necessitates a well-planned, multidisciplinary approach focusing on close monitoring before, during and after delivery. This approach may contribute to reduction of poor maternal and fetal outcomes. (C) 2018 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.Öğe Perinatal Outcome in Women Screened for Gestational Diabetes Mellitus With Normal or With One Elevated Glucose Tolerance Test Value(Galenos Yayincilik, 2007) Sayin, N. Cenk; Varol, Fusun G.; Duran, Ridvan; Acunas, Betul; Kurt, ImranObjective: To investigate the perinatal outcome of women screened for gestational diabetes mellitus (GDM) who had abnormal screening and normal oral glucose tolerance test (OGTT) results or women with a single abnormal test value in OGTT. Materials and Methods: We screened 576 pregnant women with a 50 gr oral glucose challenge test between the 24th and 26th weeks' of gestation. Women with abnormal diabetes screening test results were followed up with standard OGTT with a 100 gr oral glucose load. According to the results, 360 women were with a normal screening test (Group 1), 87 with a positive screening and all normal test values on OGTT (Group 2), 50 with a positive screening but a single abnormal test value on OGTT (gestational impaired glucose tolerance, Group 3) and 79 were diagnosed as with GDM (Group 4). Diet or diet plus insulin therapy was initiated to patients in Groups 3 and 4 as indicated. We compared perinatal outcome between these four groups. Statistical data were calculated with post hoc multiple comparison, Kruskal-Wallis and c 2 tests for comparison of means, medians or for nominal variables. Results: Women with GDM had significantly higher glycosylated hemoglobin levels, large for gestational age infants, macrosomia, neonatal jaundice, neonatal intensive care unit (NICU) admission and neonatal mortality rates but lower gestational age at delivery and 1-minute Apgar scores compared to controls. Also, there were significant differences in neonatal jaundice and NICU admission rates between Groups 1 and 3, or between 2 and 3. There were significantly more macrosomic babies in Groups 3 and 4, compared to Group 2. Discussion: Women with abnormal diabetes screening tests and negative OGTT or with gestational impaired glucose tolerance seem not to be prone to develop severe adverse perinatal outcome.Öğe Placental chorioangioma complicated with preterm delivery: A case report(Modestum Ltd, 2017) Inan, Cihan; Sayin, N. Cenk; Tastekin, Ebru; Erzincan, Selen Gursoy; Uzun, Isil; Sarikas, Nurtac; Varol, Fusun G.Chorioangioma is the most common tumor of the placenta. Since these tumors generally have small sizes, they cannot be detected during the routine ultrasonography (USG) examination and might not present any symptom. When they become larger in size, they can cause various maternal and fetal complications. We presented a patient whose obstetric USG examination revealed a placental mass compatible with chorioangioma and who had preterm delivery at the 34th gestational week. The size of the mass increased rapidly in last four weeks. The pathological examination indicated that the placental mass was 9x8 cm in size and compatible with angiomatous type chorioangioma.Öğe Pregnancies complicated by adnexal masses: a case series(Springer Heidelberg, 2008) Sayin, N. Cenk; Inal, Hasan A.; Varol, Fuesun G.Introduction Adnexal masses >= 5 cm in diameter are rare during pregnancy. Materials and methods We present our experience on six pregnant women with adnexal masses diagnosed and operated during pregnancy and/or at the time of cesarean section. Results Carefully selected cases with a unilateral mass and a solid component with normal tumor marker result can be followed until term and adnexectomy can be performed during cesarean section. On the contrary, gross adnexal masses, even with normal tumor marker levels should be operated when diagnosed, but these women might deliver small for gestational age infants. Conclusion By depending upon restricted criteria according to tumor markers, ultrasound or other radiological imaging techniques, some patients with an adnexal mass carrying an important risk factor for malignancy may be overlooked.Öğe Prenatal diagnosis of chromosomal polymorphisms: most commonly observed polymorphism on Chromosome 9 have associations with low PAPP-A values*(Taylor & Francis Ltd, 2019) Inan, Cihan; Sayin, N. Cenk; Dolgun, Z. Nihal; Gurkan, Hakan; Erzincan, Selen Gursoy; Uzun, Isil; Sutcu, HavvaIntroduction: To identify the prevalence and types of fetal chromosomal polymorphisms in pregnant women and to examine possible associations with screening test parameters. Materials and methods: Fetal chromosomal polymorphism rate was investigated in pregnant women who had been implemented for invasive prenatal test in a tertiary reference center in Thrace Region of Turkey. Fetal chromosomal polymorphisms were determined and their effects on screening tests' parameters were investigated. Possible differences in the first and second-trimester screening test parameters between women; with fetal chromosomal polymorphism who had screening test results (Group 1) and those with a normal karyotype (Group 2) were evaluated. Results: Fetal chromosomal polymorphism prevalence was 5.3% (n = 101). The most common polymorphisms were identified on chromosome 9, 1, and 16 [54.5% (n = 55); 8.9% (n = 9), and 6.9% (n = 7), respectively]. The most common polymorphic variant was 9qh+ (n = 23; 22.8%). Among the screening test parameters, significantly lower pregnancy-associated plasma protein-A (PAPP-A) (p = .028) and higher unconjugated estriol (uE3) (p = .019) values were found in Group 1. In patients having fetuses with polymorphic variants on chromosome 9, a significantly lower PAPP-A values were observed compared to women with other fetal polymorphic variants (p = .048) or women having fetuses with normal karyotype (p = .007). Conclusions: Lower PAPP-A and higher uE3 levels were observed in women having fetuses with chromosomal polymorphisms, which might affect screening test results. Lower PAPP-A levels were apparent in women having fetuses with polymorphism on chromosome 9.Öğe Quadruplet Pregnancy with Complete Mole and Three Viable Fetuses(Taylor & Francis Inc, 2022) Yener, Cem; Sayin, N. Cenk; Keskin, Fatma Elif Usturali; Altan, Esra; Ates, Sinan; Varol, FusunBackground: The coexistence of a hydatidiform mole and a fetus can occur in a multiple pregnancy, being less frequent in triplets and quadruplets because of their infrequency. With assisted reproduction, multiple pregnancies are becoming more frequent, and we can expect more frequent coexistence with a molar pregnancy. Case report: This G3, P1 30-year-old mother, after assisted conception, was diagnosed with a quadruplet pregnancy, one of which was a molar conceptus. Due to the potential for malignancy, the pregnancy was electively terminated. Conclusion: Despite the difficulty in conceiving, elective termination of a multiple pregnancy associated with a molar pregnancy may be the most judicious course of action to protect the mother's life.Öğe Rapidly growing cervical teratoma - fetal death during delivery(Hygeia Press Corridori Marinella, 2017) Cilingir, Isil Uzun; Sayin, N. Cenk; Erzincan, Selen Gursoy; Inan, Cihan; Sutcu, Havva; Dogan, Sumeyra; Can, NurayHere we present a rapidly growing fetal cervical teratoma associated with agenesis of the corpus callosum that caused an early delivery resulting in rupture of the mass and neonatal death during Cesarean section. Large cervical lesions may threaten the life of the fetus during delivery of the head.Öğe The relation of fetal colon and rectum diameters with labor in healthy late-third trimester pregnancies(Elsevier Science Bv, 2018) Inan, Cihan; Sayin, N. Cenk; Dolgun, Z. Nihal; Erzincan, Selen Gursoy; Uzun, Isil; Sutcu, Havva; Varol, FusunObjective: To investigate the associations of fetal colon-rectum diameters with labor and fetal distress or meconium passage in healthy pregnancies in the late 3rd trimester. Study design: A total of 162 healthy, singleton pregnant women at >= 36(0/7) weeks who were in the latent phase of labor (n = 69) or those not in labor (n = 93, controls) at the time of ultrasound examination were enrolled. Fetal colon (ascending, transverse, descending, sigmoid) and rectum diameters, Doppler indices of materno-fetal vessels were measured. Data were analyzed according to the mode of delivery. Results: Fetal colon-rectum diameters were smaller in women in labor compared to controls (p = 0.001). Positive correlations were observed between fetal colon-rectum diameters and interval between ultrasound and labor onset in the control group except for those who had scheduled cesarean sections (C/S) (p = 0.001). Similar colon-rectum measurements were obtained in fetuses delivered via cesarean section due to fetal distress or to other indications (p>0.05). In women who had uterine contractions during ultrasound examination; later delivered by vaginal route, no association was observed between Apgar scores and colon-rectum diameters during latent-phase (p > 0.05), and also there were significant positive correlations between different segments of colon-rectum diameters and duration of neonatal meconium passage (p < 0.05). Conclusion: Fetal colon and rectum diameters are smaller during labor and the measurements tend to diminish as the labor approaches, but do not indicate fetal distress. (C) 2018 Elsevier By. All rights reserved.Öğe Relationship between second-trimester amniotic fluid levels of Prokineticin-1 and Matrix Metalloproteinase-2 with adverse pregnancy outcome(W B Saunders Co Ltd, 2018) Erzincan, Selen G.; Varol, Fusun G.; Inan, Cihan; Sayin, N. CenkTo investigate the levels of Prokineticin-1 (PROK1) and matrix metalloproteinase-2 (MMP-2) in second-trimester amniotic fluid (AF). AF samples were investigated in 81 patients. AF-PROK1 and AF-MMP-2 were not significantly associated with adverse pregnancy outcomes (preeclampsia, intrauterine growth retardation, spontaneous preterm birth, gestational diabetes, gestational hypertension). AF-PROK1 levels in patients with abnormal first-trimester screening were significantly higher than those who underwent amniocentesis due to abnormal second-trimester screening tests (p = .04). AF-PROK1 or AF-MMP-2 do not have a role in the prediction of adverse pregnancy outcomes. (c) 2017 Elsevier Ltd. All rights reserved.
