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    Evaluation of Frequencies of HLA-A, B and DR in Thracian Population and Examination of its Relationship With Balkan Populations
    (Aves Yayincilik, Ibrahim Kara, 2008) Pala, Funda Sibel; Tabakcioglu, Kiymet; Alguenes, Cetin; Oemuerlue, Imran Kurt
    Objectives: In this study, human leukocyte antigen (HLA) allel frequencies of Thracian Turkish population were determined. Study Design: The study group consisted of 105 tissue donors who live in Thrace region of Turkey for three generations and have similar linguistic features. Polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used for genotyping of HLA-A, B and DRB1 alleles. The most frequent HLA alleles were HLA-A*02 (20.5%), HLA-B*35 (22.9%) and HLA-DR*11 (17.6%). Results: Frequencies of HLA alleles show some variations among different populations because of their highly polymorphic gene structure. Determining the distribution of HLA alleles is one of the most preferred genetical approaches for clarifying the relationship between populations. Conclusion: In this study also, HLA-DR allel frequencies were compared in order to determine the relationship between other Turkish populations and Balkan populations. It is observed that Thracian Turkish population has similar HLA-DR distributions with Balkan populations.
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    An Evaluation of the Effect of the Biological Dose of Fluoroscopic Radiation Exposure in the Operating Room
    (Aves, 2018) Yilmaz, Baris; Copuroglu, Cem; Tabakcioglu, Kiymet; Pala, Funda Sibel; Ozcan, Mert; Ciftdemir, Mert
    Objective: Through an evaluation of the biological dose, we aimed to evaluate the risks of ionizing radiation to which physicians and auxiliary healthcare personnel working in orthopedic operating rooms are exposed to via diagnostic use of fluoroscopy. Methods: Blood samples were collected from physicians and auxiliary healthcare personnel working in the orthopedic operating room. The biological dose was evaluated using micronucleus and dicentric analysis. To assess the effects of physical and chemical agents together, a total of 31,000 binucleate cells were evaluated using the micronucleus method and 16,500 metaphase plaques were evaluated using dicentric analysis, which is accepted as the most important indicator in determining the effects of radiation. Results: The study participants comprised 18 males and 5 females (16 physicians, 4 nurses, and 3 patient carers) with a mean age of 34.1 years (range, 22-58 years) who were thought to have been exposed to ionizing radiation in the working environment. The mean duration of working under ionizing radiation was 73.6 months (range, 1.5-420 months). In the blood samples, the total micronucleus frequency was determined as 8.8 +/- 1.4. In the evaluation of the 16,500 metaphysis plaques, radiation-specific dicentric was observed in 5 subjects (normal frequency: 5/10,000). As a result of the analysis made use both methods, the dose was determined to be slightly above background level, and below risk level in 6 subjects. The dose was related with medical applications in 4 of these subjects. Conclusion: Fluoroscopy should be attempted in the operating room within a restricted time as far as possible and at measurements of high kV and low mA. kV-mA values are of utmost importance for providing the best results according to the nature of the operation; the tube outlet is predefined away from the patient's skin.
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    Trakya'da yaşayan popülasyonun HLA-A, B ve DR sıklığı yönünden değerlendirilmesi ve Balkan popülasyonları ile akrabalığının gösterilmesi
    (2008) Pala, Funda Sibel; Tabakçıoğlu, Kıymet; Algüneş, Çetin; Ömürlü, İmran Kurt
    Amaç: Bu çalışmada Trakya bölgesinde yaşayan Türk popülasyonunun insan lökosit antijenleri (HLA) allel dağılımları belirlendi. Çalışma Planı: Çalışma grubu, üç kuşaktır Trakya bölgesinde yaşayan ve benzer linguistik özellikler gösteren 105 doku vericisinden oluşturuldu. HLAA, B ve DRB1 allellerinin genotiplendirmesinde Polimeraz zincir reaksiyonu-sekans spesifik primer (PZR-SSP) yöntemi kullanıldı. Tüm alleler içinde en sık gözlenenler HLA-A*02 (%20.5), HLA-B*35 (%22.9), HLA-DR*11 (%17.6) oldu. Bulgular: HLA allellerinin frekansları, HLA gen bölgesinin fazla polimorfik yapısından dolayı popülasyonlar arasında farklılık göstermektedir. Dağılımdaki bu farklılıklar ve benzerlikler toplumların birbirleriyle akrabalıklarını ortaya koymada en tercih edilen genetik yaklaşımlardan biridir. Sonuç: Bu çalışmada da diğer Türk popülasyonları ile farklı Balkan popülasyonları arasındaki akrabalıkları belirlemek amacıyla HLA-DR frekansları karşılaştırıldı. Trakya Türklerinin Balkan popülasyonlarına benzer bir HLA-DR dağılımı sergilediği görüldü.