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    Studies on the synthesis of 3-methyl-6-(substituted-urea/-thiourea)-2(3H)-benzothiazolone derivatives and antimicrobial activities
    (Natl Inst Science Communication & Information Resources-Niscair, 2015) Unal, Ayse Sibel; Onurdag, Fatma Kaynak; Ozgen, Selda; Dogruer, Deniz; Onkol, Tijen
    A series of sixteen new urea and thiourea derivatives at position 6 of 3-methyl-2(3H)-benzothiazolone ring have been prepared and studied using 1R, H-1 NMR, mass spectra and elemental analysis. The urea and thiourea derivatives have been obtained by the reaction of 6-amino-3-methyl-2(3H)-benzothiazolone with appropriate isocyanates and isothiocyanates. The antibacterial, antifungal and antimycobacterial activities of the synthesized compounds have been evaluated in vitro using microdilution and microplate methods.
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    Synthesis and Antimicrobial Evaluation of 2-(p-Substituted Phenyl)-5-[(4-substituted piperazin-1-yl)acetamido]-benzoxazoles
    (Walter De Gruyter Gmbh, 2014) Arisoy, Mustafa; Temiz-Arpaci, Ozlem; Kaynak-Onurdag, Fatma; Ozgen, Selda
    A series of 2-(p-substituted phenyl)-5-(2-{4-[(p-chloro-fluorophenyl)/phenyl] piperazin-1-yl}-lacetamido)-benzoxazoles were synthesized and tested for their antimicrobial activities. The structures of the new derivatives were elucidated by spectral techniques. The minimum inhibitory concentrations (MIC) of the new benzoxazoles, along with those of previously synthesized analogues, were determined against standard bacterial and fungal strains and drug-resistant isolates, and compared with those of several reference drugs. The new benzoxazole derivatives were found to possess a broad spectrum of antimicrobial activity with MIC values of 32 - 1024 mu g/ml. Although the standard drugs were more active against the tested pathogens, the activities of the new benzoxazoles and the reference drugs were largely similar against the drug-resistant isolates.
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    Synthesis of some piperazinobenzoxazole derivatives and their antimicrobial properties
    (Council Scientific & Industrial Res, 2016) Arisoy, Mustafa; Temiz-Arpaci, Ozlem; Kaynak-Onurdag, Fatma; Ozgen, Selda
    A series of 2-(p-substitutedphenynenzy1)-5-[3-[4-[(p-chlorophenyl)/phenyl]piperazin-1-yl]propionamido]-benzoxazoles (3-22) have been synthesized towards discovering new antimicrobial compounds in order to fight against pathogens, which have become resistant to antibiotics and are the cause of increased mortality and morbidity throughout the world. Structures of new derivatives have been elucidated by spectral techniques. New and previously synthesized benzoxazoles have been evaluated for their antibacterial and antifungal activity against standard strains, and their drug-resistant isolates in comparison with reference drugs. This study is aimed to investigate the efficacy of the antimicrobial effect of different amido bridges on the same homologue structures of benzoxazole compounds. Compounds 3-22 exhibit broad antibacterial activity with MIC (Minimum Inhibitory Concentration) values of 128-256 mu g/mL against Staphylococcus aureus and its isolate except for derivative 7 that has a MIC value of 32 mu g/mL against S. aureus isolate and compounds 3 and 22 which have MIC value of 512 mu g/mL against S. aureus. Also, the tested compounds 3-22 possess low antifungal activity with MIC values of 128 mu g/mL against Candida albicans in comparison with antifungal reference drugs, fluconazole and amphotericin B.