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    Studies on the synthesis of 3-methyl-6-(substituted-urea/-thiourea)-2(3H)-benzothiazolone derivatives and antimicrobial activities
    (Natl Inst Science Communication & Information Resources-Niscair, 2015) Unal, Ayse Sibel; Onurdag, Fatma Kaynak; Ozgen, Selda; Dogruer, Deniz; Onkol, Tijen
    A series of sixteen new urea and thiourea derivatives at position 6 of 3-methyl-2(3H)-benzothiazolone ring have been prepared and studied using 1R, H-1 NMR, mass spectra and elemental analysis. The urea and thiourea derivatives have been obtained by the reaction of 6-amino-3-methyl-2(3H)-benzothiazolone with appropriate isocyanates and isothiocyanates. The antibacterial, antifungal and antimycobacterial activities of the synthesized compounds have been evaluated in vitro using microdilution and microplate methods.
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    SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF OFLOXACIN DERIVATIVES
    (Editura Acad Romane, 2018) Dundar, Yasemin; Ulger, Mahmut; Kaynak Onurdag, Fatma; Okten, Suzan; Onkol, Tijen
    A series of novel ofloxacin derivatives were prepared and screened for their antimycobacterial activity. Among the synthesized compounds, 2, 3, 18, 19, 26 exhibited significant antimycobacterial activity. Additionally, all synthesized compounds were evaluated for their antibacterial and antifungal activity.