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Öğe Effect of examination stress on energy and nutrient intake in university students(Pakistan Medical Assoc, 2017) Memi, Gulsun; Nogay, Nalan HakimeObjective: To evaluate the changes in the energy and nutrient intake of students during examination week Methodology: The study was conducted with 32 university students, of whom 16 were male and 16 were female. Nutrient consumption record were taken for 3 days after the examination week, for a tlotal of 6 days. Results: the energy intake of all of the students was significantly higher compared to the control period. The fat rate of the energy were found to be higher in the examination period compared to the conrol period (p<0.05). Sucrose and starch consumption were higher in the examination period compared to the control period, with only the difference between sucrose consumption rates being statistically important. Conclusions: Most of the students under academic stress increased their energy and fat consumption, and female students increased their carbohydrate intake as well.Öğe The Effect of Music on Subjective Time Perception(Wiley, 2019) Gul, Tugba Kizil; Ozturk, Gulnur; Kaya, Oktay; Sen, Burcu; Memi, Gulsun; Ozturk, Levent[Abstract Not Available]Öğe Effects of Adropin and Spexin on Cardiac Inflammatory Markers; Chronic Renal Failure Model(Wiley, 2019) Memi, Gulsun; Yazgan, Burak; Tastekin, Ebru[Abstract Not Available]Öğe The Effects of Spexin on Glucose Homeostasis in an Experimental Models of Streptozotocin (STZ)-Induced Diabetes(Wiley, 2022) Memi, Gulsun; Gul, Tugba Kizil; Ozturk, Levent[Abstract Not Available]Öğe High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin(Marmara Univ, 2023) Memi, Gulsun; Ozturk, Levent; Palabiyik, OrkideAugust / September / Accepted: September ABSTRACT: The obese population has been rapidly increasing because of high-fat consumption and a sedentary lifestyle. Large amounts of dietary fat intake increase the risk of cardiovascular disease. We aimed to investigate the effects of exercise and obestatin on a high-fat diet (HFD) induced cardiac hemodynamic changes. Seventy-nine Sprague-Dawley rats (200 to 250 g) were fed either control diet or HFD for 8 weeks. In the 5th week, each diet group was subgrouped as follows; control, exercise, obestatin (25 mu g/kg, i.p), exercise+obestatin (25 mu g/kg, i.p). After the end of 4 weeks of exercise (swimming exercise, 5 days a week/ 20 min day) and obestatin administration period, all animals were sacrificed. Hearts were removed for hemodynamic measurements with the Langendorff apparatus. Blood samples were collected for biochemical measurements. Data were analyzed by Graphpad Prism 6.0. and p<0.05 was accepted as statistically significant. Cardiac contractility and hemodynamic parameters in the HFD model have been evaluated. And the effects of chronic obestatin treatment and exercise were studied together. Obestatin ameliorated derangements in LVDP, heart rate, and blood lipid levels induced by an HFD. Also, obestatin prevents decreasing BNP levels with high -fat consumption. Obestatin treatment potentiated the beneficial effects of exercise evidenced by LVDP, heart rate, blood lipids, BNP, and AT2R1 measurements. We believe that obestatin has the potential for the maintenance of cardiac function in HFD.Öğe Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin(Sage Publications Ltd, 2021) Yazgan, Burak; Avci, Filiz; Memi, Gulsun; Tastekin, EbruChronic kidney disease is a major global public health problem. The peptide hormones adropin and spexin modulate many physiological functions such as energy balance and glucose, lipid and protein metabolism. However, it is unclear whether these peptides may exert effects on renal damage, tissue remodeling, and inflammatory conditions. In view of the limited information, we aimed to investigate the effect of adropin and spexin on matrix metalloproteinase and inflammatory response genes a rat model of adenine-induced chronic kidney failure. Chronic kidney failure was induced in rats by administering adenine hemisulfate. Renal function was determined in an autoanalyzer. Histopathological modifications were assessed by H&E staining. mRNA expression levels of ALOX 15, COX 1, COX 2, IL-1 beta, IL-10, IL-17A, IL-18 IL-21, IL-33, KIM-1, MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, NGAL, TGF beta 1, TIMP-1, and TNF alpha in kidney tissue were measured by qPCR. Our results showed an increase of 24-h urine volume, serum creatinine, BUN, and urine protein levels in group with adenine-induced CKF. Adropin and spexin treatments decreased urine protein and 24-h urine volume. Renal damage, TIMP-1, IL-33, and MMP-2 increased after CKF induction, while COX 1, MMP-9, and MMP-13 levels were significantly reduced. Furthermore, KIM-1, TIMP-1, IL-33, and MMP-2 were downregulated by spexin treatment. Renal damage, NGAL, TIMP-1 IL-17A, IL-33, MMP-2, and MMP-3 decreased after adropin treatment, while MMP-13 levels were upregulated. Treatment with adropin+spexin decreased KIM-1, NGAL, TIMP-1, IL-1 beta, IL-17A, IL-18, IL-33, ALOX 15, COX 1, COX 2, TGF beta 1, TNF alpha, MMP-2, MMP-3, and MMP-7, but increased MMP-13 levels. Our findings revealed that inflammatory response and MMP genes were modulated by adropin and spexin. These peptides may have protective effects on inflammation and chronic kidney damage progression.Öğe Role of Ovarian Hormones in Psychological Stress-induced Oxidative Organ Damage in Rats(Aves Press Ltd, 2016) Memi, Gulsun; Yegen, Berrak C.Objective: Stress response varies with respect to gender via the hypothalamic-pituitary-gonadal axis. We aimed to investigate the effect of ovarian hormone deficiency on psychological stress response and oxidative damage. Methods: Female Sprague Dawley rats (250-300 g, n=56) were divided as control, sham, and ovariectomy (OVX) groups. Sham operation or surgical OVX were conducted under anesthesia. After 60 days, the rats were placed in a special chamber to induce psychological stress by electric shock and were kept in the same chamber for 30 min on the following 3 days. Glucocorticoid receptor antagonist RU-486 (10 mg/kg), oxytocin receptor antagonist atosiban (1 mg/kg), or saline was intraperitoneally administered 10 min before stress exposure. After the hole-board anxiety test, the rats were decapitated on the 4th day; tissue and blood samples were obtained. Results: Psychological stress increased cortisol levels in the RU-486-administered group, while cortisol levels were decreased in the atosiban-administered group. Serum interleukin (IL)-1 ss levels, but not TNF-alpha levels, were increased by inducing stress. Stress increased oxidative damage in the stomach, colon, and brain of ovariectomized rats (p<0.05-0.001), while atosiban partially reversed and RU-486 exaggerated oxidative damage. GSH levels that were depleted because of stress were partially replenished by administering atosiban; however, RU-486 had no effect on GSH levels. Conclusion: Although the absence of ovarian hormones during psychological stress had no effect on cortisol or anxiety levels, changes in cytokine levels and oxidative tissue damage were observed.Öğe Serum Leptin, Obestatin, and Ghrelin Levels and Gastric Emptying Rates of Liquid and Solid Meals in Non-obese Rats with Roux-en-Y Bypass Surgery or Prosthesis Placement: Implications for the Role of Vagal Afferents(Springer, 2017) Yavuz, Yunus; Kumral, Zarife Nigar Ozdemir; Memi, Gulsun; Cevik, Ozge Dagdeviren; Yegen, Cumhur; Yegen, Berrak C.Background The present study aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) and prosthesis placement on gastric emptying rate in conjunction with serum ghrelin-obestatin-leptin responses in non-obese rats with intact or denervated afferent innervation. Methods Under anesthesia, male Sprague-Dawley rats underwent either sham operation, RYGB, prosthesis, and/or Gregory cannula placement. Three weeks later, liquid or solid gastric emptying tests were performed and serum ghrelin, leptin and obestatin levels were measured. Results Both prosthesis placement and RYGB surgery delayed non-nutrient liquid emptying; while solid nutrient emptying was delayed only by RYGB. Nutrient-dependent (acid, hyperosmolal and peptone) delay in liquid emptying was abolished in rats with prosthesis. By vagal afferent denervation, delayed liquid emptying was abolished, while solid emptying was further delayed in rats with prosthesis. Ghrelin and obestatin levels were depressed in prosthesis-placed rats, but RYGB surgery had no impact on both levels. Leptin level was elevated in solid-food-given rats with prosthesis, but not changed in RYGB group, while it was reduced following liquid meal. All the changes observed in ghrelin, obestatin, or leptin levels in response to meal ingestion were reversed with vagal afferent denervation. Conclusions Both RYGB and prosthesis placement had delaying effects on gastric emptying rate of non-obese rats. Our results indicate that the short-term changes in gastric motility and hormone responses induced by volume reduction are reversed by afferent denervation, suggesting that sparing the vagal innervation could be essential for reaching optimum motility and hormone changes expected after bariatric surgery.
