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Öğe A Case of Autoimmune Encephalitis with Refractory Status Epilepticus(Kare Publ, 2019) Cakar, Merve Melodi; Aksar, Aslihan; Akpinar, Meliha; Mercan, Elif; Kehaya, Sezgin; Guldiken, BaburhanRefractory status epilepticus is usually caused by a severe brain injury and has a high rate of mortality and morbidity despite the infusion of antiepileptic drugs and anesthetic agents. Autoimmune encephalitis is one cause of refractory status epilepticus and status epilepticus may be the initial symptom. The seizures are generally resistant to standard treatment and may require immunotherapeutics. This is a description of a patient who had refractory status epilepticus despite appropriate doses of antiepileptic and general anesthetic drugs, but responded to intravenous immunoglobulin therapy. Examinations revealed an ovarian teratoma with a negative serum N-methyl-D-aspartate receptor antibody.Öğe A case of cerebral venous thrombosis accompanying with intracranial hypotension: Headache that changing character(Kare Publ, 2013) Guler, Sibel; Deniz, Cigdem; Utku, Ufuk; Kehaya, SezginSpontaneous intracranial hypotension was first described by Schalternbarn. Severe complications like cerebral venous thrombosis and subdural hemorrhage are seldomly seen. A 40-year-old man was examined for weakness of right arm started 9 months earlier and aggravated in last 3 months. He was undergo a lumbar punction because of a demyelinating plaque at C2 level in MRI. After 10 days of lumbar punction he experienced a generalised tonic clonic seizure. At cranial MRI and venography thrombosed superior sagittal and right transverse sinus and image of pachymeningitis, caused by intracranial hypotension were observed. Coincidence of these two situations together was seldomly found at literature. Thrombosis can both effect the sinuses and cortical veins. Spontaneous intracranial hypotension is a risk factor for CVT, but at only 2% CVT is seen as a complication. We think that our case can add addition to literature by having this coincidence.Öğe A Case of Uncorrected Tetralogy of Fallot Presenting with Acute Ischemic Stroke(Aves, 2014) Tekatas, Aslan; Kehaya, Sezgin; Cagli, Bekir; Akdemir, Vedat; Aynaci, Ozer; Dogru, Yuce; Aksu, FeyzaTetralogy of Fallot (FT) is the most common cyanotic congenital heart disease. FT is mainly composed of ventricular septal defect, right ventricular outflow tract obstruction, pulmonary stenosis and right ventricular hypertrophy, but also can include dextrapositioned aorta (overriding aorta), additional malformations such as atrial septal defect, and coronary artery anomalies. In the first week of life patients undergo palliative anastamosis between a pulmonary artery and subclavian artery and after they become eligible for major surgery total correction isperformed. With neurological involvement ischemic or venous stroke, syncope and seizures can occur. Generally, clinical presentation is cerebral venous thrombosis. IIschemic stroke in children is associated with hyperviscosity and microstasis, and in adults with phlebotomy, microcytosis and traditional stroke risc factors such as hypertension, diabetes mellitus and cardiac rhythm disorders. Patients with uncorrected FT rarely survive adulthood. In this study, we present a case without total correction, who lived up to the age of 39 years and presented with arterial stroke instead of expected venous thrombosis, along with stroke mechanisms in the literature.Öğe CEREBRAL VASOMOTOR REACTIVITY IN FIBROMYALGIA PATIENTS AND ITS RELATIONSHIP TO CENTRAL NEUROPATHIC PAIN(Literatura Medica, 2016) Guler, Sibel; Kurtoglu, Hakan S.; Kehaya, Sezgin; Pamuk, Nuri; Celik, YahyaBackground - Cerebral vasomotor reactivity, defined as the cerebral vasculature response to hypoxia, is not well understood in fibromyalgia (FM) patients. This study investigated the difference in the cerebrovascular reactivity (i.e., responsiveness to hypercapnia was evaluated by use of breath-holding index) to the breath-holding index (BHI) between patients with fibromyalgia and a group of normal controls. Methods - The study included 40 FM patients and 40 healthy subjects. Cerebrovascular reactivity was evaluated using the BHI, which is a nonaggressive, well-tolerated, real-time, reproducible screening method to study cerebral haemodynamics. Insonation depth and basal velocity were symmetrical and not significantly different between the two groups (p>0.05). All patients completed the Revised Fibromyalgia Impact Questionnaire (FIQR), Hospital Anxiety and Depression Scale (HADS), visual analogue scale (VAS), and the somatization subscale of the SCL-90-R symptom checklist. Results - The BHI ranged from 0.30 to 2.20 (mean 1.11 +/- 0.45) in the FM patients and 1.10 to 2.80 (mean 1.90 +/- 0.35) in the control group (p<0.001). Disease duration and right BHIaverage and left BHIaverage values exhibited a significant negative correlation (r=-61377; p<0.001, r=-0.842; p<0.001, respectively). As pain and fatigue scores increased, the right BHIaverage and left BHIaverage values decreased (r=-0.431; p=0.005, r=-0.544; p<0.001, r=-0.341; p=0.031, r=-0.644; p<0.001, respectively). Conclusions - BHI values showed that cerebrovascular reactivity in FM patients decreased in comparison to healthy individuals. BHI decreased as disease duration and severity increased. Cerebrovascular reactivity decreased in FM patients, and this phenomenon should be accepted as an abnormality. Additionally, this outcome may have been the result of a mechanism responsible for central neuropathic pain.Öğe Do Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines Change Creutzfeldt-Jakob Disease Prognosis(Galenos Publ House, 2022) Dogru, Yuce; Kehaya, Sezgin[Abstract Not Available]Öğe EFFECTS OF CHADS2 SCORE, ECHOCARDIOGRAPHIC AND HAEMATOLOGIC PARAMETERS ON STROKE SEVERITY AND PROGNOSIS IN PATIENTS WITH STROKE DUE TO NONVALVULAR ATRIAL FIBRILLATION(Literatura Medica, 2019) Aynaci, Ozer; Tekatas, Asian; Aynaci, Gulden; Kehaya, Sezgin; Utku, UfukIntroduction - The aim of this study is to evaluate utility of CHADS2 score to estimate stroke severity and prognosis in patients with ischemic stroke due to non-valvular atrial fibrillation (AF) in addition to evaluate effects of hematologic and echocardiographic findings on stroke severity and prognosis. Methods - This prospective study included 156 ischemic stroke cases due to non-valvular AF in neurology ward of Trakya University Medical School between March 2013-March 2015. National Institute of Health Stroke (NIHS) score was used to evaluate severity of stroke at admission. Carotid and vertebral Doppler ultrasonography findings, brain computed tomography (CT) and magnetic resonance imaging (MRI) of the cases were evaluated. Left atrial diameter and ejection fraction (EF) values were measured. CHADS2 score was calculated. Modified Rankin Scale was used to rate the degree of dependence. Effects of age and sex of the patients, presence of diabetes mellitus (DM), Congestive Heart Failure (CHF), Cerebrovascular Disease (CVD) and C-reactive protein (CRP) levels on CHADS2, NIHS, and mRS were evaluated. Results - In patients with age >= 75, mean NIHS score was 3.3 points and mean mRS score was 1.02 points higher, than in patient below 75 years of age. Compared with the mild risk group, cases in the high risk group had older age, higher serum D-dimer, fibrinogen and CRP levels and lower EF. A positive relation was detected between stroke severity and Hemorrhagic Transformation (HT), previous CVD history, and presence of CHF. A significant association was found between increased stroke severity and Early Neurological Deterioration (END) development. Older age, higher serum fibrinogen, D-dimer, CRP and lower EF values were associated with poor prognosis. History of CVD and presence of CHF were associated with poor prognosis. END development was found to be associated with poor prognosis. In the high-risk group, 30.3% (n = 33) had END. Among those in the high-risk group according to the CHADS2 score, END development rate was found to be significantly higher than in the moderate risk group (p < 0.05). There was a strong positive correlation between CHADS2 and NIHS scores. mRS score increased with increasing CHADS2 score and there was a strong correlation between them. Effect of stroke severity on prognosis was assessed and a positive correlation was found between NIHS score and mRS value. Discussion - Our study demonstrated the importance of CHADS2 score, haemostatic activation and echocardiographic findings to assess stroke severity and prognosis. Knowing factors which affect stroke severity and prognosis in patients with ischemic stroke may be directive to decide primary prevention and stroke management.Öğe Evaluating the Effects of Night Shifts on Attention and Executive Function of Trakya University Residents Using the Tower of Hanoi Test(Trakya Üniversitesi, 2020) Özyiğit, Irmak İrem; Certel, Alperen Taha; Söyleyici, Begüm; Kehaya, SezginAims: This study aims to evaluate the effects of night shifts on attention and executive function among residents working atTrakya University Hospital. Methods: This prospective study was performed between November 2019 – January 2020 on 83residents working at Trakya University Hospital. The Tower of Hanoi test was used to measure the attention and function level oftwo different groups of residents. The first group being residents working with night shifts and the other group being residentswith regular working hours. After the participants finished solving the puzzle, the number of moves and the finishing time wererecorded. The demographic data about smoking, coffee intake, sleep hours, departments, and hand dominance were also recorded. Results: The participants were composed of 36 (43.4 %) female and 47 (56.6 %) male residents. The difference in smokingrate and sleep time between the two groups were found to be statistically significant whereas the difference between the completion time and moves was not statistically significant. Conclusion: Smoking and duration of sleep may affect the Tower of Hanoipuzzle performance. Although residents working with night shifts did not under-perform, the importance of sleep for cognitiveskills such as attention and coordination cannot be underestimated. Stress caused by night shifts may affect reaction time forproblem-solving, but further studies are needed. Keywords: Nightshift, attention, Tower of Hanoi testÖğe Geç Postpartum Dönemde Gelişen Posterior Geri Dönüşümlü Ensefalopati Sendromu Olgusu(2018) Çakar, Merve Melodi; Kehaya, Sezgin; Özkan, Hülya; Güldiken, Babürhan Feyzullah[Abstract Nıt Available]Öğe Geçici Global Amneziyi Taklit Eden Hiponatremi(2017) Kehaya, Sezgin; Güldiken, Babürhan Feyzullah; Doğru, Yüce[Abstract Nıt Available]Öğe Hyponatremia Mimicking Transient Global Amnesia(Turkish Neurological Soc, 2017) Kehaya, Sezgin; Guldiken, Baburhan; Dogru, Yuce[Abstract Not Available]Öğe Insular cortex involvement in migraine patients with chronic pain: A volumetric radiological and clinical study(Elsevier Sci Ltd, 2024) Mammadkhanli, Orkhan; Kehaya, Sezgin; Solak, Serdar; Yagmurlu, KaanBackground: This study aimed to assess abnormalities in the insular cortex of individuals suffering from migraines and examine their associations with pain duration, medication usage, and clinical symptoms. Methods: We analyzed radiological data from 38 migraine patients who had undergone 3D iso T1-weighted brain MRI at our university hospital between 2019 and 2023. Structured questionnaires were used to collect information on participants' age, migraine type, disease duration, clinical symptoms, and medication use. Volumetric analysis was performed on the insular regions using Volbrain and 3DSlicer. The results were statistically analyzed. Results: Comparing groups with chronic pain to normal groups revealed significant differences in several insular regions, including the posterior insula (p = 0.034), parietal operculum (p = 0.04), and the entire insular cortex (p = 0.023). Further group comparisons (Group 1, 2, and 3) showed significant differences in specific insular regions. For instance, the anterior insula (p = 0.032) was associated with taste changes, the posterior insula (p = 0.010) with smell-related changes, and the central operculum (p = 0.046) with sensations of nausea. Additionally, significant changes were observed in the parietal operculum concerning nausea, photophobia, phonophobia, and changes in smell. Conclusion: To the best of our knowledge, there have been no studies investigating the relationship between clinical manifestations and volumetric correlation. This study provides insights into abnormalities in the insular cortex among migraine patients and their potential relevance to pain duration, severity, and migraine type. The results suggest that understanding alterations in insular regions possibly linked to pain could contribute to the development of innovative approaches to managing chronic pain.Öğe İntrakranial ve ekstrakranial ateroskleroza bağlı iskemik inme geçiren hastaların risk faktörlerinin karşılaştırılması ve üç aylık prognozları(Trakya Üniversitesi, 2015) Kehaya, Sezgin; Tekataş, Aslanİnme en sık izlenen nörolojik hastalıklardan biridir. İskemik inmelerin %50'si geniş arter aterosklerozuna bağlıdır. İnme ölüm sebepleri arasında tüm dünyada ilk üç sırada yer almaktadır. Dahası yüksek morbidite sebeplerindendir ve önde gelen uzun süreli engellilik nedenleri arasındadır. Çalışmamızın amacı intrakranial veya ekstrakranial ateroskleroza bağlı iskemik inme geçiren hastaların risk faktörlerini karşılaştırıp, aralarında hangi farklar olduğunu saptamak, prognozlarını belirlemek ve prognoza hangi risk faktörlerinin daha etkili olduğunu araştırmaktır. Böylelikle daha etkin bir koruma ve tedavi ile inme oranları azaltılabilir ve prognoz iyileştirilirse hastaların sekelleri azaltılabilir. Çalışmamız prospektif olarak tasarlanıp ilk 7 gün içerisinde iskemik inme nedeni ile yatırılarak tedavi edilen hastalarla yapıldı. Dahil edilme kriterleri olarak aterosklerotik inme tanısı için görüntüleme yöntemleri ile iskemik bölgeyi sulayan arteriyal yapılarda %50'den fazla stenoz veya oklüzyon saptanması, diğer olası iskemik inme nedenlerinin dışlanmış olması olarak belirlendi. Çalışmamıza Mart 2013 ile Nisan 2014 tarihleri arasında 58 intrakranial ve 57 ekstrakranial ateroskleroza bağlı inme geçiren toplam 115 hasta dahil edildi. Ekstrakranial ateroskleroz grubunda erkek hasta üstünlüğü bulundu (p=0.003). Hafif ile orta şiddetli inmeler arasında yaşın yüksek olması anlamlı bulundu (p=0.003). Bu fark ekstrakranial aterosklerozda daha belirgindi. Konjestif kalp yetmezliği ile ağır inme ilişkili bulundu (p<0.001). İntrakranial ateroskleroz grubunda erkek hastalar hafif şiddetli inme ile ilişkili bulundu (p=0.029). Alkol kullanımı daha hafif inme ile ilişkili bulundu (p=0.052). İnme şiddeti (p<0.001), yaş artışı (p=0.018), hipertansiyon varlığı (p=0.035), konjestif kalp yetmezliği (p=0.007) kötü prognoz ile ilişkili bulundu. Erkek cinsiyet (p=0.021) ve alkol tüketimi (p=0.016) iyi prognoz için anlamlı bulundu. Ekstrakranial aterosklerozda konjestif kalp yetmezliği (p=0.002) ve inme şiddeti (p<0.001) kötü prognoz ile ilişkili iken, intrakranial grupta sadece inme şiddeti kötü prognozla ilişkili bulundu (p<0.001). Sonuç olarak aterosklerotik inmelerde prognozu iyileştirebilmek için hipertansiyon gibi vasküler risk faktörlerinin daha sıkı takibi ve özellikle ekstrakranial grupta konjestif kalp yetmezliğine dikkat edilmesi gerekir.Öğe Investigation of The Effects of Serum Iron and Copper Levels in Ischemic Stroke Disease Development(2021) Ay, Arzu; Alkanlı, Nevra; Kehaya, SezginObjective: Ischemic stroke is characterized by loss of focal cerebral function due to impaired of brain-blood flow. Environmental factors and genetic factors may be effective together in the pathogenesis of ischemic stroke. Trace elements are important components of the biological structure, and toxic effects may occur when these trace elements are taken in more than the amount required for biological functions. The risk of neurological diseases such as ischemic stroke may increase as a result of imbalances in trace element levels. Therefore, the aim of this study is to investigate the effects of serum iron and copper levels in the development of ischemic stroke disease. Materials and Methods: Our study consisted of 20 ischemic stroke patients and 36 healthy controls. Serum iron and copper levels measurements were performed using atomic absorption spectrophotometer method. Results: Serum iron and copper levels were detected significantly lower in the patient group with ischemic stroke compared to the healthy control group. However, the significant difference was not determined in comparison of serum copper and iron levels according to gender between patient with ischemic stroke and healthy control groups. Conclusion: In our study, it was determined that serum iron and copper levels may be effective risk factors for ischemic stroke disease. Thus, it was concluded that serum iron and copper trace element levels may be important biomarkers that may be evaluated in the diagnosis, prognosis and treatment of ischemic stroke.Öğe Investigation of The Relationship Between IL-18 (-607 C/A), IL-18 (-137 G/C) Gene Variations and Ischemic Stroke Disease Development in Thrace Region of Turkey(Taylor & Francis Inc, 2021) Alkanli, Nevra; Ay, Arzu; Kehaya, Sezgin; Sut, NecdetBackground Ischemic stroke is a clinical condition characterized by focal or global cerebral dysfunction resulting from inhibition of brain blood flow. Genetic factors play an important role in the pathogenesis of ischemic stroke. As a result of IL-18 (-607 C/A, -137 G/C) gene variations, it is thought that binding of transcription factors may be affected and IL-18 mRNA expression can be modulated. Therefore, the purpose of our study is to investigate the roles of IL-18 (-607 C/A), IL-18 (-137 G/C) gene variations in the development of ischemic stroke in Trakya Region of Turkey. Methods Our study was performed with 90 ischemic stroke patients and 89 healthy controls. Genotype distributions of IL-18 (-607 C/A, -137 G/C) gene variations were determined using polymerase chain reaction (PCR) method. Results GC genotype and CA genotype of IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations were determined higher significantly in patent group as compared with other genotypes. However, the statistically significant difference was not determined between patients with ischemic stroke and healthy control groups in terms of IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations (p> 0,05). Allele frequencies of IL-18 (-137 G/C) and IL-18 (-607 C/A) in patient and control groups were significantly different from the Hardy-Weinberg distribution (p< .001 for all). Conclusion Although these gene variations' genotype distributions were not determined as a genetic risk factor for the development of ischemic stroke, allele frequencies of IL-18 (-137 G/C) and IL-18 (-607 C/A) in patient and control groups were significantly different from the Hardy-Weinberg distribution.Öğe Investigation of the Relationship Between Ischemic Stroke Disease and Serum Zinc Levels(Erciyes Univ Sch Medicine, 2022) Alkanli, Nevra; Ay, Arzu; Kehaya, SezginObjective: The purpose of this study was to investigate the relationship between the development of ischemic stroke disease and the serum zinc level. Materials and Methods: A total of 22 ischemic stroke patients and 38 healthy controls were included in the study. Routine blood samples of both groups were centrifuged at 5000 rpm for 5 minutes and serum samples were separated from the blood. Distilled water was added to the serum samples to make a total volume of 4 mL. Vortexing was used to homogenize the total mixture and standard solutions were used to detect zinc with an atomic absorption spectrophotometer. A concentration calibration graph was created to illustrate the results. Results: The serum zinc level was significantly higher in the patient group than in the control group (p<0.05). No statistically significant relationship was determined between the serum zinc level and parameters associated with ischemic stroke risk factors and patient complications (p>0.05). However, a strong positive significant correlation was detected between hemoglobin and hematocrit parameters (r=0.936; p<0.001), a moderately positive significant correlation between C-reactive protein and chlorine parameters (r=0.445; p=0.038), a moderately positive significant correlation between sodium and chlorine parameters (r=0.522; p=0.013), and a moderately positive significant correlation between ischemic stroke duration and potassium parameters (r=0.483; p=0.023). Conclusion: The significant increase in the serum zinc level of ischemic stroke patients and the significant positive correlations in parameters associated with ischemic stroke risk factors and complications may indicate an effect on neuronal metabolism that contributes to the development of ischemic stroke.Öğe İzole Diplopi ile Prezante Olan Santral Pontin Miyelinolizis Olgusu(2017) Kehaya, SezginSantral pontin miyelinolizis, osmotik demiyelinizasyonsendromunun, hiponatreminin hızlı düzeltilmesi sonrasıgörülenbilinmektedir. Hiponatremi olmadan da hiperosmolardurumlarda ve bazı elektrolit bozukluklarında enderolarak gelişebileceği gösterilmiştir. Uzun sürelihiperglisemi sonrası oral antidiyabetikleri kesilip insülintedavisine başlanmasından sonra diplopi gelişen,parezinin eşlik etmediği hiperosmolar durumda bir pontin bulunmuşturÖğe Kauda Ekuina Sendromunu Taklit Eden Sjögren Sendromu ile İlişkili Konus Medullaris Miyeliti: Nadir Bir Vaka(2017) Akşar, Aslıhan; Berber, Murathan; Kehaya, Sezgin; Akpınar, Meliha; Güldiken, Babürhan FeyzullahTransvers miyelit, spinal kordun inflamasyonu sonucugelişen motor, duyusal ve otonomik disfonksiyonlakarakterize klinik bir sendromdur. Spinal kordun torakalve servikal segmentleri sık tutulurken, lumbosakraltutulum seyrektir. Konus medullaris tutulumunda kaudaekuina sendromu ile karışabilecek bel ağrısı, eyertarzında duyu kaybı, alt ekstremitede paraparezi vesfinkter kusuru ile ortaya çıkabilir. Etiyolojisinde,multipl skleroz gibi multifokal, sistemik lupuseritematozuspostinfeksiyöz, aşı yapılması sonrası ya da idiyopatiknedenler yer alır. Olgumuzda, ani başlangıçlı kaudaekuina sendromu semptomları ile prezente olup Sjögrensendromu ile ilişkili akut transvers miyelit tanısı alan birhasta sunulmaktadır. Konus medullaris bölgesini içinealan longitudinal bir tutulum, Sjögren sendromuna bağlımiyelitte oldukça nadirdir. Bu vaka, kauda ekuinasendromunu düşündüren klinik bulguları ve nadirradyolojik bulguları nedeniyle sunulmaya değergörülmüştürÖğe Late-Onset Generalized Myoclonic Seizure: Case Report(Kare Publ, 2021) Ozkan, Hulya; Guldiken, Baburhan; Cakar, Merve Melodi; Sunal, Asli Sert; Kehaya, SezginMost of the epileptic seizures that begin at an advanced age are focal onset seizures due to an underlying structural lesion. Generalized myoc-lonic seizures, usually seen in adolescence, are very rare in elderly patients without a history of epilepsy. In this study, we present a 60-year-old patient with generalized myoclonic seizures with electrophysiological findings. Because of the late-onset, myoclonic jerks were first evaluated with the diagnosis of non-epileptic psychogenic attack in an external health center. The patient was diagnosed with seizure recordings in Elec-troencephalography-video monitoring. The patient responded well to the antiepileptic treatment and became seizure-free.Öğe Lesion Patterns on Early Diffusion-weighted Magnetic Resonance Imaging and Ischemic Stroke Subtypes(Turkish Neurological Soc, 2020) Ayaz, Guven; Guldiken, Baburhan; Kehaya, Sezgin; Aynaci, OzerObjective: The correct and rapid classification of the ischemic stroke subtype enables the determination of the proper treatment and a better prognosis. In this study, we investigated the association of ischemic stroke subtypes with early diffusion-weighted magnetic resonance imaging (MRI) lesion patterns. Materials and Methods: Three hundred forty-three consecutive patients with acute ischemic stroke were retrospectively evaluated. The ischemic stroke subtype for each patient was determined according to Trial of Org 10172 in Acute Stroke Treatment Classification. The lesion patterns in diffusion-weighted MRI in the first 24 hours of stroke were classified as single lesions, diffuse scattered lesions limited to one vascular area, and multiple territory lesions. The relationship between the diffusion-weighted MRI lesion patterns and ischemic stroke subtypes was investigated using the chi-square test. Results: The diffusion-weighted MRI lesion patterns showed significant differences among the ischemic stroke subtypes. Multiple territory lesions were more frequent in the cardioembolic and other determined causes groups compared with the large artery atherosclerosis group. Diffuse scattered lesions limited to one vascular area were more frequent in the large artery atherosclerosis, the unknown cause and the other determined causes groups than the others (p<0.01). Single lesions with a diameter smaller than 1.5 cm favored small vessel disease. None of the diffusion-weighted MRI lesion patterns was highly specific for any stroke subtype. Conclusion: Early diffusion-weighted MRI lesion distributions vary significantly among the ischemic stroke subtypes. When evaluated with other clinical findings, these data can help in the early determination of the ischemic stroke etiology.Öğe Lysinibacillus massiliensis Isolated from the Synovial Fluid: A Case Report(Bilimsel Tip Yayinevi, 2020) Eryildiz, Canan; Tabakcioglu, Kiymet; Kehaya, Sezgin; Sakru, Nermin; Gurcan, SabanLysinibacillus massiliensis is an aerobic, endospore-forming, gram-negative staining bacterium with peritrichous flagella belonging to the Bacillaceae family. A few cases of L. massiliensis isolated from the cerebrospinal fluid and tissue have been reported. In this study, we aimed to describe a case of L. massiliensis isolated from the synovial fluid. The synovial fluid from a 74-year-old female patient was inoculated into blood culture bottle. Gram-negative rods were observed in a gram-stained smear from a positive blood culture bottle. The bacterium was identified as Lysinibacillus sphaerkus/Lysinibacillus fusiformis, with a probability of 89% using an automated bacterial identification system (VITEK2; Biomerieux, France). Subsequently, 16S rRNA gene sequencing was performed, and the sequence was analyzed using the Basic Local Alignment Search Tool. The sequence had 99.9% (1426/1427) identity with the strain L. massiliensis (GenBank ID: NR_043092.1). To our knowledge, this is the first reported case of L. massiliensis isolated from the synovial fluid. When an endospore-forming gram-negative staining bacterium can not be identified by phenotypic characterization, L. massiliensis should be considered, and different microbiological methods should be used for identification.
