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Öğe The effects of citric acid (antioxidant) and benzoic acid (antimicrobial agent) on the mouse liver: biochemical and histopathological study(Springer, 2003) Aktac, T; Kaboglu, A; Ertan, F; Ekinci, F; Huseyinova, GThe damaging effects of citric acid and benzoic acid on mouse liver were reported. Aqueous solutions of citric acid and benzoic acid (concentrations 0.01% and 0.02%) were administered to male mice as drinking water. After 10 days, it was observed that the necrotic changes (vacuolated and glassy cytoplasm in hepatocytes, chromatin decrease, and increase of collagen fibers amongst hepatocytes) occurred in livers of all experimental groups. Uricase activity significantly increased in all treated groups (p < 0.01, p < 0.001, p < 0.002) compared to the controls. However, there was no statistically significant increase in catalase activity (p < 0.1).Öğe The relationship between 99Tcm-sestamibi uptake and ultrastructural cell types of thyroid tumours(Lippincott Williams & Wilkins, 2001) Sarikaya, A; Huseyinova, G; Irfanoglu, ME; Erkmen, N; Çermik, TF; Berkarda, SAlthough several hypotheses have been suggested regarding the accumulation of Tc-99(m)-sestamibi in rumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of Tc-99(m)-sestamibi. Thyroid scintigraphy with Tc-99(m)-sestamibi was performed on 25 patients who displayed a cold nodule on previous pertechnetate scintigraphy. Tumour-to-thyroid (T/N) uptake ratio was measured semiquantitatively. Surgery was performed in all patients and cytological evaluations were done by EM. Histopathology revealed six papillary carcinomas, 16 follicular adenomas and three Hurthle cell tumours. Thyroid cells were classified as A and B cells using EM. The cytoplasm of an A cell has the normal amount of mitochondria, whereas cytoplasm of a B cell (mitochondria-rich oxyphilic cell) contains abundant mitochondria. The median T/N ratio on the early scan for an A-cell tumour was 1.21 (range, 0.74-3.2), late T/N ratio was 1.25 (range, 0.72-3.85). The T/N ratio for the B-cell tumours was 1.42 (range, 0.6-3.6) on the early scan and 1.18 (range, 0.64-5.58) on the late scan. There was no statistically significant difference between T/N ratios of A- and B-cell tumour groups. A significant difference was also not seen between early and late T/N ratios. According to our findings, Tc-99(m)-sestamibi accumulates in thyroid rumours with both A and B cells, therefore these results suggest that the mitochondrial content of tumours is not only responsible for sestamibi uptake and retention. ((C) 2001 Lippincott Williams & Wilkins).Öğe Ultrastructural properties of promelanosomes and melanosomes in melanotic and amelanotic malignant melanoma(Iop Publishing Ltd, 1998) Huseyinova, G; Mamedov, R; Yalcinkaya, S; Necefov, T; Isayev, I[Abstract Not Available]Öğe Use of mometasone furoate aqueous nasal spray in the treatment of rhinitis medicamentosa: An experimental study(Mosby, Inc, 2005) Tas, A; Yagiz, R; Yalcin, O; Uzun, C; Huseyinova, G; Adali, MK; Karasalihoglu, AROBJECTIVE: We aimed to investigate, histopathologic changes in the nasal mucosa of guinea pig's after prolonged administration of oxymetazoline and the development of rhinitis medicamentosa, and the efficacy of mometasone furoate aqueous nasal spray and saline in reversing the ultrastructural changes attributable to rhinitis medicamentosa. METHODS: In the study, 24 male guinea pigs (500 to 600 gr) were used. Oxymetazolin (0.05%) was sprayed into the nasal cavities of the guinea pigs 3 times daily for 8 weeks. At the end of this period, 6 guinea pigs were killed and examined to make sure that the animals had developed rhinitis medicamentosa. The remaining guinea pigs were randomly divided into 3 groups. In the first group, one spray-puff of 0.05% mometasone furoate aqueous nasal spray (50 mu g) was applied twice daily for 14 days. In the second group, saline solution (0.9% NaCl) was applied twice daily for 14 days. No treatment was performed in the third group. At the end of the treatment period, nasal mucosal changes were evaluated by light microscopy and electron microscopy. RESULTS: After oxymetazolin application for 8 weeks, the main histologic changes were edema, congestion, proliferation of subepithelial glands, and squamous cell metaplasia. After topical mometasone furoate aqueous spray application for 2 weeks, the edema fluid was found to diminish markedly. In the saline and no treatment groups, edema and congestion continued. In these groups of guinea pigs, fibrosis has been seen in the nasal mucosa. CONCLUSION. We found that mometasone furoate nasal spray was effective against experimentally induced rhinitis medicamentosa in guinea pigs. Mometasone furoate nasal spray may have value in the treatment of patients with rhinitis medicamentosa.
