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Öğe Avoiding Liver Injury with Papaverine and Ascorbic Acid Due to Infrarenal Cross-Clamping: an Experimental Study(Soc Brasil Cirurgia Cardiovasc, 2017) Huseyin, Serhat; Guclu, Orkut; Yuksel, Volkan; Erkul, Gulen Sezer Alptekin; Can, Nuray; Turan, Fatma Nesrin; Canbaz, SuatObjective: Ischemia-reperfusion injury after acute ischemia treatment is a serious condition with high mortality and morbidity. Ischemia-reperfusion injury may result in organ failure particularly in kidney, lung, liver, and heart. In our study, we investigated the effects of papaverine and vitamin C on ischemia-reperfusion injury developed in the rat liver after occlusion-reperfusion of rat aorta. Methods: 32 Sprague-Dawley female rats were randomized into four groups (n=8). Ischemia was induced with infrarenal aortic cross-clamping for 60 minutes; then the clamp was removed and reperfusion was allowed for 120 minutes. While the control group and the ischemia-reperfusion group did not receive any supplementary agent, two other groups received vitamin C and papaverine hydrochloride (papaverine HCL). Liver tissues were evaluated under the light microscope. Histopathological examination was assessed by Suzuki's criteria and results were compared between groups. Results: In ischemia-reperfusion group, severe congestion, severe cytoplasmic vacuolization, and parenchymal necrosis over 60% (score 4) were observed. In vitamin C group, mild congestion, mild cytoplasmic vacuolization and parenchymal necrosis below 30% (score 2) were found. In papaverine group, moderate congestion, moderate cytoplasmic vacuolization and parenchymal necrosis below 60% (score 3) were observed. Conclusion: An ischemia of 60 minutes induced on lower extremities causes damaging effects on hepatic tissue. Vitamin C and papaverine are helpful in reducing liver injury after acute ischemia reperfusion and may partially avoid related negative conditions.Öğe Basilic vein superficialization for hemodialysis vascular access(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2013) Yuksel, Volkan; Halici, Umit; Huseyin, Serhat; Guclu, Orkut; Canbaz, Suat; Ege, Turan; Sunar, HasanBackground: This study aims to discuss the outcomes of superficialization of basilic vein technique in brachiobasilic arteriovenous fistula formation and to present our experience. Methods: Between January 2006 and January 2012, 170 patients (74 males, 96 females; mean age 60.7 +/- 9.1 years; range 31 to 83 years) who underwent basilic vein superficialization surgery in our clinic were included. All patients were examined under Doppler ultrasonography preoperatively. Demographic data of the patients, maturation time and complications were recorded. The mean follow-up was 12 months. Results: Non-dominant upper limb was preferred for surgery. Of the 170 patients who were operated, 166(97.6%) underwent hemodialysis. The mean maturation time was 61 days. Massive bleeding in the postoperative period occurred in two patients (1.2%). Wound infection was observed in eight patients (4.7%) in the early postoperative period. The most common reason for primary failure was thrombosis, which was observed in 48 patients (28.2%). The primary and secondary patency rates of the fistulas were 77% and 82%, respectively at one-year. Conclusion: Arteriovenous fistula formation through superficialization of the basilic vein offers satisfactory results in chronic hemodialysis patients with reasonable postoperative complication rate.Öğe Bilateral Brachial Artery Aneurysms with Distal Embolisms in a Patient with Prolonged Crutch Compression(Korean Soc Vascular Surgery, 2021) Simsekl, Baran; Guclu, Orkut; Huseyin, Serhat; Yuksel, VolkanChronic axillary crutch use may lead to axillary or brachial artery aneurysms and associated axillobrachial thromboembolic complications. Most of these aneurysms remain asymptomatic and undiagnosed until a complication occurs. Early diagnosis and appropriate surgical management of the aneurysms is required for a favorable outcome. We report a case of bilateral brachial artery aneurysms with left radial and ulnar artery embolisms in a patient who had been using crutches for 33 years due to a congenital skeletal anomaly.Öğe Central Retinal Artery Occlusion in Takayasu's Arteritis as the First Presentation of the Disease(Hindawi Ltd, 2016) Guclu, Hande; Gurlu, Vuslat Pelitli; Ozal, Sadjk Altan; Guclu, OrkutTakayasu's arteritis (TA) is a chronic inflammatory granulomatous vasculitis which affects large and medium arterial vessels. The disease involves especially subclavian arteries and aortic branches but it can consist of any arteries. The major pathology is granulomatous panarteritis with intima proliferation and defects of the elastic lamina of the vessels. We present a case of central retinal artery occlusion in TA as the first presentation of the disease. To the best of our knowledge, the present case is the first case that demonstrates central retinal artery occlusion as an initial manifestation in TA. A 48-year-old woman was admitted to our clinic with the complaint of sudden and painless vision loss in her right eye for one day. Although retinal artery involvement is a very rare presentation in TA, it is important to recall TA particularly in young patients with retinal artery occlusion.Öğe Clinical correlation of biopsy results in patients with temporal arteritis(Assoc Medica Brasileira, 2017) Yuksel, Olkan; Guclu, Orkut; Tastekin, Ebru; Halici, Umit; Huseyin, Serhat; Inal, Volkan; Canbaz, SuatObjective: Temporal arteritis is systemic vasculitis of medium and large sized vessels. The lowest incidence rates were reported in Turkey, Japan and Israel. We aimed to investigate the results of patients with biopsy-proven temporal arteritis and those classified according to the American College of Rheumatology criteria from a low-incidence region for temporal arteritis. The results of our study are noteworthy, since there is limited data on pathologic diagnosis of temporal arteritis in Turkey. Method: We studied the medical records, laboratory findings such as erythrocyte sedimentation rate and C-reactive protein levels, biopsy results, and postoperative complications of all the patients operated for temporal artery biopsy at our clinic. We used the computerized laboratory registry that keeps all records of 42 consecutive temporal artery biopsy results from January 2011 to December 2016. Results: The mean age was 66 +/- 12.5 years. The most common manifestations on admission were temporal headache, optic neuritis and jaw claudication, respectively. Temporal artery biopsy results confirmed tempoal arteritis in eight out of 42 (19%) patients. There was no statistically significant difference between biopsy-positive and biopsy-negative groups in terms of sex, age, erythrocyte sedimentation rate, C-reactive protein and biopsy length. Conclusion: We were not able to find a correlation between the analysis of biopsy results and clinical evaluation of patients with temporal arteritis. We suggest that diagnosis of temporal arteritis depends on clinical suspicion. Laboratory examination results may not be helpful in accurate diagnosis of tempoal arteritis.Öğe Comparison of early period results of blood use in open heart surgery(Medknow Publications & Media Pvt Ltd, 2016) Huseyin, Serhat; Yuksel, Volkan; Guclu, Orkut; Turan, Fatma Nesrin; Canbaz, Suat; Ege, Turan; Sunar, HasanBackground: Various adverse effects of homologous blood transfusion detected particularly in open heart surgery, in which it is frequently used, lead researchers to study on autologous blood use and to evaluate the patient's blood better. Due to the complications of homologous blood transfusion, development of techniques that utilize less transfusion has become inevitable. We aimed to evaluate the effects of acute normovolemic hemodilution (ANH) in patients undergoing open heart surgery. Materials and Methods: In this study, 120 patients who underwent open heart surgery were included. Patients were grouped into three: Autologous transfusion group (Group 1), homologous transfusion group (Group 2), and those received autologous blood and homologous blood products (Group 3). Patient data regarding preoperative characteristics, biochemical parameters, drainage, extubation time, duration of stay at intensive care, atrial fibrillation (AF) development, and hospital stay were recorded. Results: A statistically significant difference (P < 0.005) was found in favor of autologous group (Group 1) with respect to gender, body surface area, European System for Cardiac Operative Risk Evaluation, smoking, hematocrit levels, platelet counts, urea, C-reactive protein levels, protamine use, postoperative drainage, frequency of AF development, intubation period, stay at intensive care and hospital stay, and amount of used blood products. Conclusion: The use of autologous blood rather than homologous transfusion is not only attenuates side effects and complications of transfusion but also positively affects postoperative recovery process. Therefore, ANH can be considered as an easy, effective, and cheap technique during open heart surgery.Öğe Evaluation of Pericardial Fluid C-Type Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery(Georg Thieme Verlag Kg, 2017) Guclu, Orkut; Karahan, Oguz; Karabacak, Mustafa; Yuksel, Volkan; Huseyin, Serhat; Mavitas, BinaliBackground Neurohumoral and hemodynamic mechanisms have an effect on cardiac activity. C-type natriuretic peptide (CNP) is accessible in the cardiovascular system. The aim of this study was to determine whether CNP concentrations in pericardial fluid and blood are related to cardiac dysfunction in patients undergoing coronary artery bypass graft surgery. Materials and Methods In this study, 40 patients undergoing coronary artery bypass grafting were enrolled. The patients were separated into two groups according to left ventricular (LV) ejection fraction (EF): group 1 contained 28 patients with normal LV systolic function (LVEF >= 50%) and group 2 contained 12 patients with impaired LV systolic function (LVEF < 45%). Plasma and pericardial fluid samples were acquired during surgery to measure CNP levels. Results In group 1, CNP levels were detected to be 0.46 +/- 0.10 ng/mL in plasma and 0.66 +/- 0.8 ng/mL in pericardial liquid. In group 2, these levels were 0.51 +/- 0.09 and 0.79 +/- 0.12 ng/mL, respectively. CNP levels were determined to be significantly higher in patients with low EF compared with those with normal EF in pericardial fluid concentrations (p = 0.013). Conclusions CNP level in pericardial fluid is a more sensitive and proper marker of LV dysfunction than CNP levels in plasma. To the best of our knowledge, this study is the first to examine pericardial fluid CNP levels in patients undergoing coronary artery bypass surgery. It may have a valuable role in organizing cardiac remodeling and hypertrophy.Öğe Factors affecting surgical outcomes after superior mesenteric artery thromboembolism(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2017) Yuksel, Volkan; Guclu, Orkut; Yilmaz, Elif Cicek; Huseyin, Serhat; Ozkara, Taha; Sezer, Yavuz Atakan; Canbaz, SuatBackground: In this study, we aimed to evaluate the operative results of superior mesenteric artery thromboembolism and influential factors for mortality in patients undergoing surgery for acute mesenteric ischemia. Methods: Between January 2011 and December 2016, 28 consecutive patients (15 males, 13 females; mean age 71.2 +/- 10 years; range 48 to 89 years) diagnosed and operated for acute mesenteric ischemia were included in the study. The results of open revascularization procedures and influential factors for mortality were retrospectively analyzed. Results: Abdominal pain was the major complaint, followed by nausea and vomiting. The diagnosis was confirmed by computed tomography angiography and Duplex ultrasonography. Thromboembolectomy was performed in the majority of the patients, while autologous saphenous vein bypass and transposition were performed in eligible patients. Revascularization procedures prevented bowel resection in 10 patients. The mortality rate was 35.7% due to respiratory, renal, and cardiac pathologies. Postoperative respiratory failure and admission to hospital later than six hours after the onset of abdominal pain were identified as the factors affecting mortality. Conclusion: Our study results showed that postoperative respiratory failure and late admission after the onset of abdominal pain were associated with postoperative mortality, whereas intestinal resection requirement did not contribute to the mortality rates. Based on our study results, we suggest that exploratory laparotomy and thromboembolectomy are essential in evaluating the viability of the bowel and in continuation of the mesenteric perfusion.Öğe FOLFIRI-Mediated Toxicity in Human Aortic Smooth Muscle Cells and Possible Amelioration with Curcumin and Quercetin(Humana Press Inc, 2020) Guclu, Orkut; Doganlar, Oguzhan; Yuksel, Volkan; Doganlar, Zeynep BanuSystemic chemotherapy-mediated cell toxicity is a major risk factor for cardiovascular disease and atherosclerosis. Life-threatening acute events of the FOLFIRI (irinotecan, folinic acid and 5-fluorouracil) regimen are mainly due to DNA damage induced by antimetabolite and topoisomerase inhibition effects. However, the role of human aortic smooth muscle cells (HaVSMCs) in this process and the mechanisms of oxidative stress, DNA and protein damage and apoptosis have not been investigated. Therefore, the effects of curcumin and quercetin on HaVSMC survival in the generation of molecular and cellular toxicity by FOLFIRI treatment and the involvement of vital cellular signalling pathways were investigated. We analysed both FOLFIRI toxicity and the therapeutic potential of quercetin and curcumin in terms of HaVSMC damage using molecular probe and florescence staining, Random Amplified Polymorphic DNA (RAPD), qRT-PCR and Western blot assays. Our study presents two preliminary findings: (a) in HaVSMCs, FOLFIRI treatment significantly induces oxidative damage to both DNA and protein, leading to a dramatic increase in caspase-dependent apoptotic death through P53-mediated Caspase3-dependent mitochondrial apoptosis, and results in TNF-alpha/Caspase8-mediated necrotic death, and (b) flavonoids not only regulate the expression of genes encoding antioxidant enzymes and increase DNA damage but also limit programmed and necrotic cell death processes in HaVSMCs. Our results clearly indicate the potential for curcumin and, particularly, quercetin as preventative chemotherapeutic interventions for cardiovascular toxicity induced by the FOLFIRI regime in HaVSMCs.Öğe Graft Materials for Popliteal Artery Patch Plasty(Elsevier Science Inc, 2015) Iscan, Sahin; Cakir, Habib; Yurekli, Ismail; Guclu, Orkut; Huseyin, Serhat; Yuksel, Volkan[Abstract Not Available]Öğe Impact of Surgeon Experience During Carotid Endarterectomy Operation and Effects on Perioperative Outcomes(Soc Brasil Cirurgia Cardiovasc, 2016) Yuksel, Volkan; Ozdemir, Ahmet Coskun; Huseyin, Serhat; Guclu, Orkut; Turan, Fatma Nesrin; Canbaz, SuatObjective: We evaluated the effect of surgeon experience on complication and mortality rates of carotid endarterectomy operation. Methods: Fifty-nine consecutive patients who underwent carotid endarterectomy between January 2013 and February 2016 were divided into two groups. Patients who had been operated by surgeons performing carotid endarterectomy for more than 10 years were allocated to group 1 (experienced surgeons; n=34). Group 2 (younger surgeons; n=25) consisted of patients operated by surgeons independently performing carotid endarterectomy for less than 2 years. Both groups were compared in respect of operative results and postoperative complications. Results: No intergroup difference was found for laterality of the lesion or concomitant coronary artery disease. In group 1, signs of local nerve damage (n=2; 5.9%) were detected, whereas in group 2 no evidence of local nerve damage was observed. Surgeons in group 1 used local and general anesthesia in 3 (8.8%) and 31 (91.2%) patients, respectively, while surgeons in group 2 preferred to use local and general anesthesia in 1 (4%) and 24 (96%) patients, respectively. Postoperative stroke was observed in group 1 (n=2; 5.9%) and group 2 (n=2; 5.8%). Conclusion: Younger surgeons perform carotid endarterectomy with similar techniques and have similar results compared to experienced surgeons. Younger surgeons rarely prefer using shunt during carotid endarterectomy. The experience and the skills gained by these surgeons during their training, under the supervision of experienced surgeons, will enable them to perform successful carotid endarterectomy operations independently after completion of their training period.Öğe In vitro effects of L-carnitine on coronary artery bypass grafts(Pulsus Group Inc, 2013) Guclu, Orkut; Yuksel, Volkan; Huseyin, Serhat; Ege, Turan; Canbaz, Suat; Sungun, MutasimBACKGROUND: The gold standard treatment for multivessel coronary revascularization is coronary artery bypass grafting. The internal mammary artery and saphenous vein grafts are the conduits most frequently used for these operations. Spasm of arterial and venous grafts is a significant problem during the operation. OBJECTIVES: To evaluate the acute in vitro effects of L-carnitine on internal mammary artery and saphenous vein grafts using a tissue bath. METHODS: Ten consecutive patients who underwent elective coronary artery bypass grafting were enrolled in the present study (nine men, one woman; mean [+/- SD] age 62 +/- 9.1 years). Samples from left internal mammary artery and saphenous vein grafts were collected from each patient. Submaximal smooth muscle contraction was achieved by adding 1 mu M phenylephrine, and L-carnitine was then added to the solution. The concentration-response curves of the vasodilation response were obtained. RESULTS: In the internal mammary graft samples, the vasodilation response to L-carnitine was 64.3 +/- 11.1% at a concentration of 5 mM. In the saphenous vein graft samples, the vasodilation response to L-carnitine was 41.5 +/- 11.4% at a concentration of 5 mM. There was a statistically significant difference (P<0.001) between the response of the internal mammary artery and saphenous vein grafts in the in vitro tissue bath system. CONCLUSIONS: These results indicate that L-carnitine is a potential vasodilatory drug for internal mammary artery and saphenous vein grafts.Öğe In vitro effects of prostaglandin E1, prostaglandin I2 and papaverine on internal thoracic artery graft(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2015) Misirlioglu, Ganime; Huseyin, Serhat; Yuksel, Volkan; Guclu, Orkut; Karadag, Hakan; Canbaz, Suat; Ege, TuranBackground: This study aims to investigate the effects of prostaglandin E1, prostaglandin I2, and papaverine on internal thoracic artery grafts which are used during coronary artery bypass graft operations. Methods: Ten patients (9 males, 1 female; mean age 53.7 years; range 46 to 68 years) who were operated in our clinic between March 2013 and September 2013 were enrolled in the study. Dose-dependent effects of prostaglandin E1 and prostaglandin I2 on internal thoracic artery at a concentration interval of 10(-9) M-10(-2.5) M were observed. Results: While prostaglandin I2 had stronger relaxation response than prostaglandin E1 on internal thoracic artery graft, papaverine had the strongest relaxation response. Conclusion: Prostaglandin E1 and prostaglandin I2, which are used in the treatment of many aterosclerotic cardiovascular and peripheral artery diseases, may prevent vasoconstriction in internal thoracic artery grafts. Further clinical studies are required regarding decreasing perioperative mortality and morbidity by increasing graft patency.Öğe Investigation of the effects of ellagic, vanillic and rosmarinic acid on reperfusion-induced renal injury(Clinics Cardive Publ Pty Ltd, 2023) Gurmen, Alper; Guclu, Orkut; Huseyin, Serhat; Can, Nuray; Ozgun, Eray; Buyukadali, Mursel; Reyhancan, AdemIntroduction: The aim of this study was to investigate the effects of ellagic, vanillic and rosmarinic acid on reperfusion-related kidney damage, developed in an experimental lower-extremity ischaemia/reperfusion (I/R) model.Methods: Forty-eight female Sprague-Dawley rats were divid-ed into six groups. A median laparotomy and dissection were performed. In the I/R group, 60 minutes of ischaemia followed by 120 minutes of reperfusion was achieved. In addi-tion one group was given 100 mg/kg ellagic acid, one group was given 12 mg/kg vanillic acid, one group was given 50 mg/ kg rosmarinic acid and one group was given all three drugs 15 minutes before clamp removal. Bilateral kidney and blood samples were taken in all groups.Results: Tubular epithelial degeneration, necrosis of the tubule epithelium and vessel wall thickening were significantly higher in the I/R group. Some parameters in the groups that were given drugs were found to be lower than in the I/R group and close to that of the control group. Total oxidant status (TOS) and oxidative stress index (OSI) were significantly higher and total antioxidant status (TAS) was significantly lower in the I/R group. Although not statistically significant in the groups given drugs, TAS was higher, and TOS and OSI were lower than in the I/R group.Conclusion: The antioxidant effect of ellagic, vanillic and rosmarinic acid administration may have beneficial effects on renal damage after reperfusion in acute lower-extremity ischaemia. This study is expected to provide information for future clinical trials.Öğe Left ventriculo-pulmonary artery fistula(Springer India, 2022) Simsek, Baran; Huseyin, Serhat; Guclu, Orkut; Yuksel, VolkanThe morbidity and mortality of complicated endocarditis remains a serious problem. Left ventriculo-pulmonary artery fistula after culture-negative native aortic valve endocarditis is quite rare. A very rare case of left ventriculo-pulmonary artery fistula arising as a result of culture-negative native aortic valve endocarditis in a 70-year-old patient with no underlying medical history other than acute cholangitis has been reviewed in the light of literature.Öğe Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats(Taylor & Francis Inc, 2020) Doganlar, Oguzhan; Doganlar, Zeynep Banu; Ovali, Mehmet Akif; Guclu, Orkut; Demir, Ufuk; Dogan, Ayten; Uzun, MetehanObjective This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods The fetal heart samples were obtained from melatonin administrated RUPP rats Results Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.Öğe Pericardial SCUBE1 levels may help predict postoperative results in patients operated on for coronary artery bypass graft surgery(Clinics Cardive Publ Pty Ltd, 2021) Ozkara, Taha; Yuksel, Volkan; Guclu, Orkut; Huseyin, Serhat; Ozgun, Eray; Turan, Fatma Nesrin; Canbaz, SuatIntroduction: Signal peptide-CUB epidermal growth factor like domain-containing protein (SCUBE1) is a newly described, secretable and measurable cellular surface protein associated with atherosclerotic lesions in humans, which may be involved in hypertension and cardiovascular pathologies. We aimed to detect normal SCUBE1 levels in pericardial fluid and investigate the effects of SCUBE1 values on postoperative outcomes after coronary artery bypass surgery. Methods: Between February 2016 and March 2017, 184 consecutive patients were included in the study. Group 1 consisted of patients with unstable angina pectoris, group 2 of patients with non-ST-elevation myocardial infarction, group 3 of patients with ST-elevation myocardial infarction, and group 4 consisted of patients operated on due to non -coronary reasons. Pericardial fluid and arterial blood SCUBE1 values, demographic variables and postoperative results were noted and compared. Results: Normal SCUBE1 level in pericardial fluid was 0.049 +/- 0.061 ng/ml. Arterial SCUBE1 levels of smokers were higher. Pericardial SCUBE1 levels were higher in patients requiring postoperative intra-aortic balloon pump support and patients needing peri-operative temporary cardiac pacing. High pericardial SCUBE1 values did not correlate with postoperative stroke, prolonged intensive care unit stay and mortality. Conclusion: High levels of pericardial SCUBE1 may help us predict the need for postoperative intra-aortic balloon pump support and the need for temporary cardiac pacing, however they were not helpful in predicting prolonged intensive care unit stay and early postoperative mortality.Öğe Retinal ganglion cell complex and peripapillary retinal nerve fiber layer thicknesses following carotid endarterectomy(Springer, 2019) Guclu, Orkut; Guclu, Hande; Huseyin, Serhat; Korkmaz, Selcuk; Yuksel, Volkan; Canbaz, Suat; Gurlu, Vuslat PelitliPurpose To examine changes in retinal ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (RNFL) thicknesses by optical coherence tomography (OCT) in contralateral and ipsilatateral eyes of carotid artery stenosis (CAS) patients before and after carotid endarterectomy (CEA). Methods Forty-two consecutive patients diagnosed with CAS (70-99% stenosis rate) who underwent CEA were included in this prospective cross-sectional study. The indication for CEA was based on the Asymptomatic Carotid Atherosclerosis Study. Doppler ultrasonography and computed tomography angiography were performed to calculate CAS. All the subjects underwent an ophthalmological examination, including best corrected visual acuity (BCVA), intraocular pressure (IOP) measurements, biomicroscopy, fundoscopy, and OCT before and after the surgery. ResultsThe mean preoperative intraocular pressure was 15.2 +/- 2.1mmHg in the ipsilateral eye and 15.8 +/- 2.7 in the contralateral eye. The mean post-operative intraocular pressure in the ipsilateral and contralateral eye was 18.6 +/- 3.0 and 19.3 +/- 3.8, respectively. The intraocular pressure was significantly higher in postoperative eyes (p=0.0001). There was a statistically significant decrease in peripapillary RNFL thickness in superior quadrants postoperatively in ipsilateral eyes. The retinal GCC layer thickness was not significantly different before and after CEA in ipsilateral and contralateral eyes. Conclusions Carotid endarterectomy results in thinning of the superior peripapillary RNFL thickness. To the best of our knowledge, this is the first study to examine peripapillary RNFL and GCC thicknesses before and after CEA.