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Öğe The effect of L-lysine on serum sialic acid levels in isoproterenol-induced myocardial infarction in rats(Turkish Biochem Soc, 2011) Uzgur, Selda; Usta, Ufuk; Goekmen, Selma SueerObjectives: To investigate the effect of L-lysine on serum total and lipid-bound sialic acid levels in isoproterenol-induced myocardial infarction and to evaluate the role of cell damage in the elevation of sialic acid post-infarction. Material and Methods: Male albino rats of Wistar strain were divided into three groups randomly: control, isoproterenol and isoproterenol+L-lysine. Myocardial infarction was produced with 150 mg/kg of isoproterenol administered intraperitoneally twice at an interval of 24 hour. L-Lysine was given orally (5 mg/kg/day) for 5 days. Existence of experimental infarction was confirmed by histopathological changes and the elevation of troponin I. The levels of serum total and lipid-bound sialic acid were determined by the methods of Warren and Katopodis, respectively. Results: Isoproterenol caused a significant elevation in serum troponin I, total and lipid-bound sialic acid levels and a prominent atrophy and fibrotic changes confirming myocardial infarction in heart tissue. L-Lysine significantly prevented troponin I, total and lipid-bound sialic acid increase in serum and atrophy and connective tissue development in heart tissue. Conclusion: Cell damage may play an important role in serum sialic acid elevation after myocardial infarction. Conflict of interest: The authors have no conflict of interest.Öğe Serum total and lipid bound sialic acid levels in patients with benign and nonmelanom malignant skin tumors(Walter De Gruyter Gmbh, 2007) Kazezoglu, Cemal; Goekmen, Selma Sueer; Sunar, Bendigar; Aygit, Cemal; Cakir, BeyhanIt has been reported that sialic acid containing oligosaccharides play an important role in the adhesion between cancer cells and endothelial cells and metastatic potential of tumor cells is proportional to cell surface sialylation. In the present study, we investigated whether there is a change in serum total and lipid bound sialic acid levels of patients with benign and non-melanom malignant skin tumors and, evaluated whether the measurement of sialic acid levels may be useful clinically in distinguishing patients with benign skin tumors from those with non-melanom malignant skin tumors. In this study, 27 patients with malignant skin tumors ( 16 men, age 50.78 +/- 12.46 years), 39 patients with benign skin tumors ( 17 men, age 48.59 +/- 16.23 years) were included. Serum total and lipid bound sialic acid determination was performed by the thiobarbituric acid method described by Warren and, the resorsinol method described by Katopodis, respectively. Student's T test and Z test were used to analyze the results. The mean serum total and lipid bound sialic acid levels were found to be 63.01 +/- 11.89 mg/dl and 15.77 +/- 2.44 mg/dl, respectively in patients with benign skin tumors; and 65.95 +/- 7.30 mg/dl and 16.70 +/- 3.80 mg/dl, respectively in patients with non-melanom malignant skin tumors. Serum total sialic acid and lipid bound sialic acid of patients with benign skin tumors were not different from those of patients with non-melanom malignant skin tumors. The percentage of lipid bound sialic acid was found to be 25.3 in patients with non-melanom malignant skin tumors, 25 in patients with benign skin tumors. There was no significant difference between the value of lipid bound sialic acid percentage in these groups. Our finding that there is no significant difference between serum total and lipid-bound sialic acid levels of patients with non melanom malignant skin tumors which are not able to metastase and patients with benign skin tumors supports the studies reporting that sialic acids play an important role in metastases.