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Öğe A primary Sjogren's syndrome patient with distal renal tubular acidosis, who presented with symptoms of hypokalemic periodic paralysis(Springer Heidelberg, 2005) Soy, M; Pamuk, ÖN; Gerenli, M; Çelik, YAlthough renal tubular acidosis (RTA), secondary to autoimmune interstitial nephritis, develops in a large proportion of patients with Sjogren's syndrome (SS), most of the subjects are asymptomatic. Here, we shall present a 39-year-old female patient who came to us with hypokalemic periodic paralysis (HPP), and who was later diagnosed with distal RTA. The patient, who had xerostomia and xerophthalmia for a long period of time, was diagnosed with primary SS from serologic and histologic findings. The patient recovered by being prescribed potassium replacement therapy. Although renal biopsy was not performed, corticosteroids were administered because HPP indicated severe interstitial nephritis. HPP did not reoccur during a 2-year follow-up period. We also review cases with SS-related distal RTA and HPP.Öğe The relationship between insulin resistance and serum osteoprotegerin level in obese patients(Nature Publishing Group, 2004) Ugur-Altun, B; Altun, A; Gerenli, M; Tugrul, A[Abstract Not Available]Öğe The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity(Elsevier Ireland Ltd, 2005) Ugur-Altun, B; Altun, A; Gerenli, M; Tugrul, AAim: We investigated the relationship between insulin resistance and serum osteoprotegerin (OPG) levels in healthy obese subjects and healthy lean controls. Methods: Fifty obese subjects (age: 31 +/- 8 years) and 24 lean controls (age: 30 7 years) were included in the study. We used the homeostasis model assessment for insulin resistance (HOMA-IR) index as the index of insulin resistance. OPG levels were measured with the commercial ELISA kit. Obese subjects were studied in three groups: Group I (n = 25) HOMA-IR index < 2.24, Group II (n = 13) index 2.24-3.59, Group III (n = 12) index > 3.59. Group IV (n = 24) was the lean controls with HOMA-IR index < 2.24. Results: Obese subjects with increased insulin resistance (Group III) had lower OPG values than other groups (11.88 +/- 7.43 pg/ ml, 16.39 +/- 6.39 pg/ml, 17.37 +/- 9.61 pg/ml, and 18.1 +/- 6.65 pg/ml, respectively; Group I versus Group III p = 0.036; Group III versus Group IV p = 0.012). We also found significant inverse correlations between OPGc (corrected for BMI) and fasting glucose (r = -0.325, p = 0.005), fasting insulin (r = -0.404, p = 0.0001) as well as HOMA-IR (r = -0.428, p = 0.0001). Increased fibrinogen level was found in Group III than Group IV (9.32 +/- 1.97 mu mol/1 versus 7.47 +/- 1.65 mu mol/1, respectively; p = 0.005). In conclusion, insulin resistance in obesity is associated with decreased serum OPG levels and increased fibrinogen levels. The relationship between serum OPG levels and HOMA-IR may provide an insight into vascular endothelial dysfunction in obesity. (c) 2004 Elsevier Ireland Ltd. All rights reserved.Öğe Vasculitis and cerebral infarcts(B M J Publishing Group, 2003) Soy, M; Gerenli, M; Çelik, Y[Abstract Not Available]
